showing 36 of ~574560 from 574555 documents
La presencia negra en el Perú
2021
LOS ESCALVOS NEGROS AFRICXANOS HAN SIDO LOS PRINCIPALES PROTAGONISTAS SILENCIOSOS Y NO VISIBILIZADOS EN LA VIDA SOCIAL, ECONOMICA Y CULTURAL EN LA HISTORIA DEL PERU. SIN EMBARGO, A PESAR DE SU POSICION SUBORDINADA, DISCRIMINADA Y SEGREGADA, LOS AFROAMERICANOS TUVIERON LA CAPACIDAD DE INTERACTUAR EN LA ECONOMIA, LAS ARTES, LA RELIGION PERUANAS NO OCASIONALMENTE, SINO DE FORMA HABITAUL, COTIDIANA Y PERMANENTE.
Add-On Effect of Postural Instructions to Abdominopelvic Exercise on Urinary Symptoms and Quality of Life in Climacteric Women with Stress Urinary In…
2021
The aim of this study was to investigate the add-on effect of postural instructions to an abdominopelvic exercise program on incontinence urinary symptoms (UI symptoms) and quality of life (QoL) in climacteric women with stress urinary incontinence (SUI). A randomized controlled trial was performed with a total of 40 climacteric women with SUI aged between 46 and 75 years old. Participants were randomly assigned to two groups: a group performing an abdominopelvic exercise program (AEP) (n = 20) and a group performing abdominopelvic exercise with the addition of postural instructions (AEPPI) (n = 20). Primary outcome measures were UI symptoms, UI impact and QoL related to UI (UI-QoL), measur…
Perspectives on Leadership in Early Childhood Education and Care Centers Through Community of Practice
2021
This article investigates early childhood education and care (ECEC) leadership through the concept of community of practice (COP). The focus is on ECEC leaders’ perceptions regarding their leadership during the educational changes taking place in the context of Finnish ECEC. The purpose is to increase understanding of how leaders see themselves in relation to the ECEC multi professional working community and practices of distributed leadership. The data are five focus group interviews of ECEC leaders analyzed with directed content analysis within the theoretical frame of domain, practice, and community forming the core of COP in Lave and Wenger. The results show how all three COP component…
Ecological aspects of plants inhabiting Mediterranean cliffs. Challenges and prospects of life in vertical environments
2021
[ES] Esta tesis investiga las oportunidades, desafíos y limitaciones para la investigación en el campo de la ecología vegetal, en el contexto de los acantilados mediterráneos. En concreto, las especies casmofiticas, cuyos hábitats naturales se caracterizan por su acusada pendiente. Las laderas de las montañas de piedra caliza en la proximidad del mar, en la parte central y occidental del área mediterránea se consideran objetos de estudio. Los estudios se llevaron a cabo en los cinturones costeros de montaña de las costas del noroeste de Sicilia y la costa diánica en la Comunidad Valenciana. El primer capítulo, titulado "The complexity of environmental factors: cliff microclimate", investiga…
Function of nasal odorant metabolism in vertebrate olfaction
2021
National audience
Antitumoral activity of curcumin: an adjuvant therapeutic strategy
2021
Curcumin, an active substance contained in an Indian spice called turmeric or curcuma, is well known for its anti-inflammatory and antioxidant properties. In recent times, it was taken into account and studied as an antitumoral molecule, by relying on its interference on several biological mechanisms, such as the inhibition of inflammatory mediators, the enhancement of detoxifying enzymes’ action and processes of cell growth and proliferation. Studies show how the high dosage of curcumin in vitro inhibits colorectal tumor cells, pancreatic tumor cells, lung cancer cells and glioblastoma’s cells, interfering in signaling pathways as Wnt/β-catenin, NF-kB and PI3K/Akt and leading to cell cycle…
Clinical benefits of a Bayesian model for plasma-derived factor VIII/VWF after one year of pharmacokinetic-guided prophylaxis in severe/moderate hemo…
2021
Abstract Introduction Individual pharmacokinetic (PK) profiling in hemophilia A (HA) helps to individualize prophylaxis using population PK models (popPK). A specific popPK model for plasma-derived factor VIII containing von-Willebrand Factor (pdFVIII/VWF) was developed. Aim To compare standard versus PK-driven prophylaxis, using a generic or a specific popPK model for pdFVIII/VWF. Materials and methods A prospective study conducted in HA patients in prophylaxis with pdFVIII/VWF (Fanhdi®) comparing three one-year study periods: (1) standard prophylaxis, (2) PK-guided prophylaxis using a generic pdFVIII popPK model which described FVIII activity irrespective of FVIII concentrate, and (3) PK-…
Effects of Functional Strength Training on Functional Movement and Balance in Middle-Aged Adults
2021
Functional movement deficiencies cause falls and injuries in adults. Functional strength training (FST) is emerging as a new training method for athletes, middle-aged and older adults, to improve functional movement: The present study was conducted in order to investigate the effects of FST on balance and functional movement in healthy and independent middle-aged adults. The sample for this study consisted of 46 physically active individuals (24 female and 22 male). A total of 46 subjects were divided based on randomly into the functional strength training (FST) group (n = 26) aged: 51.55 ± 3.73 years; height: 168.69 ± 8.8 cm; body mass: 75.88 ± 12.18; and traditional s…
Function and Fiber-Type Specific Distribution of Hsp60 and αB-Crystallin in Skeletal Muscles: Role of Physical Exercise
2021
Simple Summary Skeletal muscle represents about 40% of the body mass in humans and it is a copious and plastic tissue, rich in proteins that are subject to continuous rearrangements. Physical exercise is considered a physiological stressor for different organs, in particular for skeletal muscle, and it is a factor able to stimulate the cellular remodeling processes related to the phenomenon of adaptation. All cells respond to various stress conditions by up-regulating the expression and/or activation of a group of proteins called heat shock proteins (HSPs). Although their expression is induced by several stimuli, they are commonly recognized as HSPs due to the first experiments showing thei…
Relational analysis and the ethnographic approach : constructing preschool childhood
2021
This article elaborates the relational ontology in an ethnographic study. The aim is to seek relational construction of preschool practice and how children’s positions are constructed in it. The study is based on the understanding that ethnography and relational sociology share the idea that society emerges through repeated relations. The ontological thinking of relational sociology is applied in a micro-level analysis of three episodes from a Finnish preschool. We propose that relations appear in every single ethnographical episode and that carefully analysed repetitive relations can reveal a stabilised organisational structure. The analysis shows how the position of one child is structuri…
Exploring Variation in Norwegian Social Science Teachers’ Practice Concerning Sexuality Education: Who Teachers Are Matters and So Does School Culture
2021
This article explores teaching practice concerning sexual harassment and abuse in Norwegian upper secondary schools based on phone interviews with 64 social studies teachers. This study portrays gr...
Segmentación del turista deportivo: el caso del espectador de la Fórmula 1
2021
El trabajo pretende identificar grupos de turistas de un evento deportivo, el GP Europa de Fórmula 1, con relación a su motivación para el consumo deportivo y características básicas que definen dichos grupos para conocer los perfiles de turista de un gran evento deportivo. Para caracterizar a los sujetos se utilizó el análisis clúster con una muestra de 148 asistentes al evento, turistas nacionales e internacionales. Los resultados obtenidos muestran la existencia de cuatro grupos de sujetos bien definidos: los sociales (formado por los que obtienen fuertes connotaciones sociales asistiendo al evento, el 17,6% de la muestra), los ostentosos (son el 17,5% de la muestra, que sin una motivaci…
Early Tumor Size Reduction of at least 10% at the First Follow-Up Computed Tomography Can Predict Survival in the Setting of Advanced Melanoma and Im…
2021
Early tumor size reduction (TSR) has been explored as a prognostic factor for survival in patients with advanced melanoma in clinical trials. The purpose of this analysis is to validate, in a routine clinical milieu, the predictive capacity of TSR by 10% for overall survival (OS) and progression-free survival (PFS) and to compare its predictive performance with the RECIST 1.1 criteria.This retrospective study was approved by the local ethics committee. A total of 152 patients with both CT before immunotherapy initiation and at first response evaluation after immunotherapy initiation were included. Prior to statistical analysis, treatment response was trichotomized as follows: Complete respo…
1,2‐Benzothiazine Derivatives from Sulfonimidamides by Metal‐Catalyzed Annulation Reactions in Solution and under Solvent‐Free Mechanochemical Condit…
2021
Advanced synthesis & catalysis (2021). doi:10.1002/adsc.202001505 special issue: "Hot Topic: C-H Activation"
Leverage Control and Quantitative Management: The Analysis of Amplification Effect on Financial System
2021
Maintaining the stability of financial leverage is a task in macro-economic management and also a challenge to be faced. Financial amplification characteristics dominate financial leverage system with low risk of capabilities, and the efficiency of this ability has two-sides results and proposes a lot of risks, however, most researchers have not found the best ways to solve this problem. Therefore, taking positive measures to strengthen the management of the financial system leverage feature becomes very important. In this paper, authors use comparative study and data analysis to illustrate the main problems of financial system leverage, the effect of leverage amplification characteristics,…
Reconstrucción de un flujo de derrubios: el desastre de Marines (Valencia) de octubre de 1957
2021
espanolEn la manana del 14 de octubre de 1957 una masa compuesta principalmente por bloques y fango procedente de la vertiente oeste de las crestas del Rodeno (Sierra Calderona) asolo la mayor parte del casco urbano de Marines (Valencia), causando 6 victimas mortales y numerosos danos materiales. A partir de la consulta de documentacion de archivo, de la revision de diversas fotografias, del examen de los depositos sedimentarios y de los testimonios de algunos supervivientes, este trabajo ensaya una reconstruccion del episodio y una interpretacion geomorfologica del movimiento de masa. Los materiales analizados han permitido elaborar una cartografia detallada de los procesos y formas del ev…
Analysis of the differences in serve effectiveness between Billie Jean King Cup (former Fed Cup) and Davis Cup doubles tennis matches
2021
The doubles game has considerable relevance in professional tennis, especially in team competitions such as the Billie Jean King Cup (former Fed Cup) (BJKC) and the Davis Cup (DC). However, there are very few studies that have carried out quantitative notational analysis to provide information on the specific features of this tennis modality. The goal of this study was to analyse the differences in serve direction and effectiveness of male and female teams in matches played at BJKC and DC ties. A total of 29,207 serves; 7,578 of BJKC and 21,628 of DC matches were analysed. The data was obtained through the Hawk-Eye system. The results showed that with the first serve, both BJKC and DC team…
On the impact of side methyl groups on the structure and vibrational properties of β-carotenoids. The case of butadiene and isoprene
2021
Abstract Theoretical consideration about the impact of methyl groups on the structure and vibrational properties of β-carotenoids, using medium size molecules of trans-butadiene and trans-isoprene, are reported. Density functional theory (DFT) calculations with correlation-consistent and polarization-consistent basis sets were applied to trans-1,3-butadiene and trans-isoprene as the smallest building bricks of β-carotenoids. Their structure and harmonic vibrations were estimated in the complete basis set limit (CBS) using the non-linear least square fit. Optimized geometries and harmonic frequencies, obtained with B3LYP and BLYP density functionals and large basis sets, were favorably repro…
Mapping routine measles vaccination in low- and middle-income countries
2021
The safe, highly effective measles vaccine has been recommended globally since 1974, yet in 2017 there were more than 17 million cases of measles and 83,400 deaths in children under 5 years old, and more than 99% of both occurred in low- and middle-income countries (LMICs)1–4. Globally comparable, annual, local estimates of routine first-dose measles-containing vaccine (MCV1) coverage are critical for understanding geographically precise immunity patterns, progress towards the targets of the Global Vaccine Action Plan (GVAP), and high-risk areas amid disruptions to vaccination programmes caused by coronavirus disease 2019 (COVID-19)5–8. Here we generated annual estimates of routine childhoo…
Creación de materiales didácticos digitales y uso de tecnologías por parte de los docentes de Primaria. Un estudio de casos
2021
espanolEste articulo pretende analizar como la creacion y usos de Materiales Didacticos Digitales por parte de los docentes potencia un cambio metodologico en las aulas de Primaria. Para ello se ha realizado un analisis de documentos y webs de tres estudios de caso, entrevistas semiestructuradas con los diferentes agentes y observacion de las aulas de cuarto, quinto y sexto de Primaria de tres Comunidades Autonomas (Canarias, Galicia y Valencia). Los resultados muestran que los docentes abogan por la creacion de sus propios materiales, con el fin de adecuarlos a las caracteristicas de cada grupo-clase y disenar una propuesta de ensenanza contextualizada y que potencie la formacion de sujeto…
Percepción del cambio climático en alumnado de 4º del Grado en Educación Primaria (Universidad de Valencia, España) a partir de la información de los…
2021
El cambio climático, sus causas y efectos suponen uno de los principales desafíos del siglo XXI. La enseñanza sobre este fenómeno constituye un reto para la formación de los/as futuros/as maestros/as de Primaria debido a la responsabilidad docente sobre la comprensión y posible adaptación a este fenómeno global. Los objetivos de este trabajo son: 1) Explorar y conocer los principales medios desde donde los/as futuros/as maestros/as de Primaria reciben información sobre el cambio climático; y 2) Reconocer las causas y consecuencias que se aluden en estos medios (según la percepción de los/as estudiantes) para identificar la concepción que se tiene sobre este fenómeno. A modo de estudio de ca…
Designing a Low-Fat Food Packaging: Comparing Consumers’ Responses in Virtual and Physical Shopping Environments
2021
This paper aims to test to what extent emotional responses towards a low-fat product presented virtually converge with emotional responses toward this product when presented physically. Second, we want to probe if low-order emotions (physiological/unconscious responses) and high-order emotions (cognitive/conscious responses) converge to explain healthy product choices. To this end, 83 young participants were engaged in our experiment. Two packaging design variables were manipulated with the help of a real company (the color and the message), so that six different packages were created. Two different buying contexts were simulated: A virtual context and a physical context. Physiological resp…
Documentación del Patrimonio Arqueológico mediante el procedimiento del diseño por contacto con las superficies musivas pavimentales y parietales del…
2021
[EN] The archaeological excavations that have been carried out in the Hispano-Roman city of Valeria have exhumed the remains of a thermal complex from the 1st century AD that it was in service for four centuries and that, after its abandonment, it was barely spoiled for its constructive and decorative materials. This circumstance has allowed the conservation of a paving mosaic in a good state of preservation. In this same room has been recovered an important collection of fragments corresponding to the parietal musive decoration that constitutes a unique corpus in the Roman archaeology of the province of Cuenca. Due to the historical-archaeological importance of this type of elements, a met…
Dairy consumption, plasma metabolites, and risk of type 2 diabetes.
2021
Background Epidemiologic studies have reported a modest inverse association between dairy consumption and the risk of type 2 diabetes (T2D). Whether plasma metabolite profiles associated with dairy consumption reflect this relationship remains unknown. Objectives We aimed to identify the plasma metabolites associated with total and specific dairy consumption, and to evaluate the association between the identified multi-metabolite profiles and T2D. Methods The discovery population included 1833 participants from the Prevencion con Dieta Mediterranea (PREDIMED) trial. The confirmatory cohorts included 1522 PREDIMED participants at year 1 of the trial and 4932 participants from the Nurses' Hea…
Do Adolescents Who Meet Physical Activity Recommendations on Weekdays Also Meet Them on Weekends? A Cross-Sectional Study in Colombia.
2021
The purpose of this study was to examine whether Colombian adolescents fulfill physical activity (PA) recommendations by type of day depending on several variables. A cross-sectional study was carried out on a sample of 2624 adolescents from Neiva (Colombia) using the Seven Day PA Recall and the Family Affluence Scale II self-reported questionnaires. Statistical analyses were performed to find any differences by gender, socioeconomic status, PA recommendations accomplishment, participation in organized and non-organized PA, parents&rsquo
Future directions in acquired hemophilia A
2021
bssm: Bayesian Inference of Non-linear and Non-Gaussian State Space Models in R
2021
We present an R package bssm for Bayesian non-linear/non-Gaussian state space modelling. Unlike the existing packages, bssm allows for easy-to-use approximate inference based on Gaussian approximations such as the Laplace approximation and the extended Kalman filter. The package accommodates also discretely observed latent diffusion processes. The inference is based on fully automatic, adaptive Markov chain Monte Carlo (MCMC) on the hyperparameters, with optional importance sampling post-correction to eliminate any approximation bias. The package implements also a direct pseudo-marginal MCMC and a delayed acceptance pseudo-marginal MCMC using intermediate approximations. The package offers …
Escuela Digital: estrategias y materiales didácticos digitales en Educación Infantil y Primaria
2021
Título en español y portugués Resumen basado en la publicación El impacto de la tecnología en todos los ámbitos de la vida cotidiana es innegable. La sociedad está expuesta a una gran revolución tecnológica, con cambios acelerados y nuevas exigencias formativas y laborales. El contexto educativo no es ajeno a dichos cambios y desde la educación se están haciendo esfuerzos, más o menos notables, dirigidos a responder a las diversas demandas sociales de la revolución tecnológica. ESP
Spanish Curriculum in Cariology for undergraduate dental students: Proceedings and consensus.
2021
INTRODUCTION Cariology is today a broad-based discipline and in the Spanish university teaching field, all this knowledge is not unified in a curriculum. Therefore, the aim was to develop a consensus text based on the European Core Curriculum, updated, and adapted to the characteristics of the Spanish university environment. MATERIALS AND METHODS A Spanish Cariology Curriculum Group (SCCG) was set up with members of the Spanish Society of Epidemiology and Oral Public Health (SESPO), Spanish Society of Conservative and Aesthetic Dentistry (SEOC) and Spanish Society of Paediatric Dentistry (SEOP) and university experts to adapt the European Core Curriculum in Cariology for undergraduate denta…
false
2021
Funding: This research was funded through the 2017–2018 Belmont Forum and BiodivERsA joint call for research proposals, under the BiodivScen ERA-Net COFUND program, with the following funding organizations: the Academy of Finland (Univ. Turku: 326327, Univ. Helsinki: 326338), the Swedish Research Council (Swedish Univ. Agric. Sci:2018–02440, Lund Univ.: 2018–02441), the Research Council of Norway (Norwegian Instit. for Nature Res.,295767), and the National Science Foundation (Cornell Univ., ICER-1927646), and we also acknowledge the Swedish Environmental Protection Agency.
Thermophysical Properties of Mixtures of 1-Ethyl-3-methylimidazolium Methylsulfate or 1-Ethyl-3-methylimidazolium Thiocyanate with Alcohols
2021
In the present paper, densities, speeds of sound, and viscosities of four binary mixtures containing the ionic liquids 1-ethyl-3-methylimidazolium methylsulfate and 1-ethyl-3-methylimidazolium thio...
Analysis of mobile applications aimed at early childhood: technical, pedagogical, design and content characteristics
2021
This article analyzes the technical, pedagogical, design and content characteristics of a sample of applications for children up to 5 years old, available on the Google Play platform. The study is part of an investigation titled: «Los materiales didácticos digitales en la Educación Infantil. Análisis y propuestas para su uso en la escuela y el hogar» (RTI2018-093397-B-I00) in which research teams belonging to three Autonomous Communities of the Spanish State (Islas Canarias, Galicia and Valencia) participate. The methodology used was based on content analysis. The 23 most popular apps on Google Play in June 2020 are analyzed. Three of them are the most downloaded in Spanish homes during the…
Non-surgical correction of gummy smile using temporary skeletal mini-screw anchorage devices : a systematic review
2021
Background There are no studies that have systematically reviewed randomized control trials and/or prospective cohort studies that have assessed the significance of temporary skeletal mini-screw anchorage devices (TSAD) for the correction of gummy-smile. The aim of the present systematic review was to assess the significance of non-surgical correction of gummy smile using TSAD. Material and methods The addressed focused question was "Are temporary skeletal mini-screw anchorage devices effective for the correction of gummy smile?" Indexed databases were searched up to and including May 2020. Different combinations of the following key-indexing terms were used: anchorage; gummy smile, mini-sc…
The neurochaperonopathies: Anomalies of the chaperone system with pathogenic effects in neurodegenerative and neuromuscular disorders
2021
The chaperone (or chaperoning) system (CS) constitutes molecular chaperones, co-chaperones, and chaperone co-factors, interactors and receptors, and its canonical role is protein quality control. A malfunction of the CS may cause diseases, known as the chaperonopathies. These are caused by qualitatively and/or quantitatively abnormal molecular chaperones. Since the CS is ubiquitous, chaperonopathies are systemic, affecting various tissues and organs, playing an etiologic-pathogenic role in diverse conditions. In this review, we focus on chaperonopathies involved in the pathogenic mechanisms of diseases of the central and peripheral nervous systems: the neurochaperonopathies (NCPs). Genetic …
Depression and workaholism in undergraduates: Examining gender as a moderator
2021
Introduction: This study aims to examine the association between depression and workaholism among university students. Methods: Participants were 182 undergraduates at a large university in the South of Poland, aged between 20–28 years old (M = 22.17, SD = 1.39), including 102 women (56%). The cross-sectional study used the Beck Depression Inventory (BDI) and the Work Addiction Risk Test (WART). Results: This study shows that depression and workaholism levels are significantly lower in Physical Education students than other faculties' students. Gender moderates the relationship between workaholism and depression. Women demonstrate a stronger association between depression and workaholism th…
MultivariateApart: Generalized partial fractions
2021
We present a package to perform partial fraction decompositions of multivariate rational functions. The algorithm allows to systematically avoid spurious denominator factors and is capable of producing unique results also when being applied to terms of a sum separately. The package is designed to work in Mathematica, but also provides interfaces to the Form and Singular computer algebra systems.