showing 36 of ~574560 from 574555 documents
Mediterranean sharks and rays need action
2021
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Semantic processing in children with autism spectrum disorder
2021
El presente estudio analizó el procesamiento semántico de un grupo de niños con trastorno del espectro autista (n= 24), con el objetivo principal de averiguar si presentan diferencias en comparación con un grupo de niños con desarrollo típico (n = 24). Para ello, se realizó un análisis del contenido de los ítems del subtest de información del WPPSY-III, estableciendo una serie de categorías en función del tipo de demanda semántica requerida: asociación significante-significado, relación experiencial y conocimiento general. Los resultados obtenidos apoyan la idea de que los niños con autismo realizarían un procesamiento semántico de la información de la misma manera que los niños sin autismo…
Tectonic significance of the Variscan suture between Brunovistulia and the Bohemian Massif
2021
The Velke Vrbno Dome crops out at the boundary between the Brunovistulian Terrane and the internal parts of the Bohemian Massif. Here, eclogite boudins occur within an Ediacaran volcano-sedimentary sequence. Strong Nb depletion (Nb/Nb* = 0.19–0.82) combined with moderately positive Nd isotopic compositions (eNd(i) = +3.89 – +5.77) is used to argue for emplacement of the eclogite protoliths in a transitional supra-subduction to continental-rift setting. Conversely, heterogeneously enriched large ion lithophile elements and highly radiogenic Sr isotopic ratios (87Sr/86Sr = 0.705–0.720) are interpreted to have been modified following fluid infiltration subsequent to eclogite-facies metamorphis…
Discovery of a Major QTL Controlling Trichome IV Density in Tomato Using K-Seq Genotyping
2021
[EN] Trichomes are a common morphological defense against pests, in particular, type IV glandular trichomes have been associated with resistance against different invertebrates. Cultivated tomatoes usually lack or have a very low density of type IV trichomes. Therefore, for sustainable management of this crop, breeding programs could incorporate some natural defense mechanisms, such as those afforded by trichomes, present in certain Solanum species. We have identified a S. pimpinellifolium accession with very high density of this type of trichomes. This accession was crossed with a S. lycopersicum var. cerasiforme and a S. lycopersicum var. lycopersicum accessions, and the two resulting F2 …
Spectroscopy along Flerovium Decay Chains: Discovery ofDs280and an Excited State inCn282
2021
A nuclear spectroscopy experiment was conducted to study α-decay chains stemming from isotopes of flerovium (element Z=114). An upgraded TASISpec decay station was placed behind the gas-filled separator TASCA at the GSI Helmholtzzentrum fur Schwerionenforschung in Darmstadt, Germany. The fusion-evaporation reactions ^{48}Ca+^{242}Pu and ^{48}Ca+^{244}Pu provided a total of 32 flerovium-candidate decay chains, of which two and eleven were firmly assigned to ^{286}Fl and ^{288}Fl, respectively. A prompt coincidence between a 9.60(1)-MeV α particle event and a 0.36(1)-MeV conversion electron marked the first observation of an excited state in an even-even isotope of the heaviest man-made eleme…
"You helped me out of that darkness" Children as dialogical partners in the collaborative post-family therapy research interview.
2021
Applying Dialogical Methods for Investigations of Happening of Change (DIHC), this study investigated how children who had been diagnosed with an oppositional defiant or conduct disorder participated in a collaborative post‐therapy research interview and talked about their experiences of family therapy. The results showed that the children participated as dialogical partners talking in genuine, emotional, and reflective ways. Encountered as full‐membership partners, the children also co‐constructed meanings for their sensitive experiences. However, their verbal initiatives and responses appeared in very brief moments and could easily have been missed. The collaborative post‐therapy intervie…
Protective Effects of Statins Administration in European and North American Patients Infected with COVID-19: A Meta-Analysis
2021
AbstractSevere acute respiratory syndrome coronavirus 2 has spread rapidly throughout the world, becoming an overwhelming global health emergency. The array of injuries caused by this virus is broad and not limited to the respiratory system, but encompassing also extensive endothelial and systemic tissue damage. Since statins effectively improve endothelial function, these drugs may have beneficial effects in patients with coronavirus disease 2019 (COVID-19). Therefore, this investigation aimed to provide an updated overview on the interplay between statins and COVID-19, with particular focus on their potentially protective role against progression toward severe or critical illness and deat…
Motivators to Recommend Social Network Contacts to Employer
2021
Social networks are an important tool for human resources management to identify employees. The number of suitable candidates to fill a position is decreasing. Companies need new channels for the recruiting process. This paper evaluates the usefulness of the different social networks under consideration of the advantages and disadvantages. “Employee recruit Employees” is a useful tool to identify suitable candidates. The aim of the paper is to analyse the different motivators and reasons of individuals to recommend somebody to identify employer. The research methods are: theoretical studies of published scientific findings and survey with 251 respondents. The data obtained in the survey wer…
Tris(5-aryl-1,3,4-oxadiazolyl)benzotrithiophenes : discotic liquid crystals with enormous mesophase ranges
2021
C1q–Ha matrix regulates the local synthesis of hyaluronan in malignant pleural mesothelioma by modulating has3 expression
2021
Increased hyaluronic acid (HA) production is often associated with cancer progression. In malignant pleural mesothelioma (MPM), HA is found at elevated levels in pleural effusions and sera of patients, and it has been widely debated whether MPM cells are able to produce HA by themselves or through the release of growth factors stimulating other cells. Another key component of the MPM microenvironment is C1q, which can act as a pro-tumorigenic factor favoring cell adhesion, migration and proliferation. The aim of the current study was to prove that MPM primary cells are able to synthesize HA and to inquire the stimulus given by C1q&ndash
Gut Microbiota Condition the Therapeutic Efficacy of Trastuzumab in HER2-Positive Breast Cancer.
2021
Abstract Emerging evidence indicates that gut microbiota affect the response to anticancer therapies by modulating the host immune system. In this study, we investigated the impact of gut microbiota on immune-mediated trastuzumab antitumor efficacy in preclinical models of HER2-positive breast cancer and in 24 patients with primary HER2-positive breast cancer undergoing trastuzumab-containing neoadjuvant treatment. In mice, the antitumor activity of trastuzumab was impaired by antibiotic administration or fecal microbiota transplantation from antibiotic-treated donors. Modulation of the intestinal microbiota was reflected in tumors by impaired recruitment of CD4+ T cells and granzyme B–posi…
Performance of production modules of the Belle II pixel detector in a high-energy particle beam
2021
The Belle II experiment at the Super B factory SuperKEKB, an asymmetric $e^+e^-$ collider located in Tsukuba, Japan, is tailored to perform precision B physics measurements. The centre of mass energy of the collisions is equal to the rest mass of the $\Upsilon(4S)$ resonance of $m_{\Upsilon(4S)} = 10.58\,\rm GeV$. A high vertex resolution is essential for measuring the decay vertices of B mesons. Typical momenta of the decay products are ranging from a few tens of MeV to a few GeV and multiple scattering has a significant impact on the vertex resolution. The VerteX Detector (VXD) for Belle II is therefore designed to have as little material as possible inside the acceptance region. Especial…
Connecting Gien Castle to its Landscape: Faunal, Environmental and Buildings Analyses (Loiret, France)
2021
International audience; Gien castle is a listed monument of French architectural heritage. Today it houses the National Museum of Hunting and its collection. Organised visits to the site have traditionally lacked any clear mention of the castle’s historical background. Recently, however, archaeological excavations and building analysis in 2011–2015 produced a wealth of new knowledge about the castle’s medieval origins and history, and about its relationship to its landscape. During the ninth and tenth centuries and then in the fifteenth century the castle occupied a strategically exceptional position reflecting the connection with its environment, notably the strong connection between the c…
Sustainable Development and the Practice of Spatial Planning: A Proposal of Criteria for Measuring the Overall Sustainability of Planning Actions in …
2021
The sustainable city debate is gaining ground in recent years, featuring as a prominent issue in several policy documents of the European Commission, and enjoying support by the main organisations and institutions at international level. At the same time, improving local governance standards by involving citizens in local decision-making is a recurring issue in the debate on local democracy and enhancement of community cohesion. This paper presents an analysis of the European experience and best practice relating sustainable development to the day-to-day practice of spatial planning. The overall purpose is creating a proposal of indicators for measuring the sustainability of planning action…
Experimentally Realizing Efficient Quantum Control with Reinforcement Learning
2021
Robust and high-precision quantum control is crucial but challenging for scalable quantum computation and quantum information processing. Traditional adiabatic control suffers severe limitations on gate performance imposed by environmentally induced noise because of a quantum system's limited coherence time. In this work, we experimentally demonstrate an alternative approach {to quantum control} based on deep reinforcement learning (DRL) on a trapped $^{171}\mathrm{Yb}^{+}$ ion. In particular, we find that DRL leads to fast and robust {digital quantum operations with running time bounded by shortcuts to adiabaticity} (STA). Besides, we demonstrate that DRL's robustness against both Rabi and…
Polymers with antiviral properties: A brief review.
2021
Viruses that are pathogenic to humans and livestock pose a serious epidemiological threat and challenge the world's population. The SARS-CoV-2/COVID-19 pandemic has made the world aware of the scale of the threat. The surfaces of various materials can be a source of viruses that remain temporarily contagious in the environment. Few polymers have antiviral effects that reduce infectivity or the presence of a virus in the human environment. Some of the effects are due to certain physical properties, e.g., high hydrophobicity. Other materials owe their antiviral activity to a modified physicochemical structure favoring the action on specific virus receptors or on their biochemistry. Current re…
Corporate Governance Effects on Firm Performance: a Literature Review
2021
The objective of this paper is to analyze the results of recent empirical research concerning the impact of corporate governance on firm performance and reflect potential research design problems which lead to inconsistent results. By means of a literature review including all articles of academic journal data bases with a journal quality rating of at least a C-rating in the VHB Journal Rating or above ‘3’ in the ABS Academic Journal Rating, respectively, the recent empirical research articles are analyzed regarding their main results. Two main groups of studies are identified: studies on company level to determine the impact of single corporate governance variables such as board size, chai…
The invasive stink bug Halyomorpha halys affects the reproductive success and the experience-mediated behavioural responses of the egg parasitoid Tri…
2021
Invasive species, because of their lack of co-evolutionary history with recipient communities, can act as “evolutionary traps” causing disconnects between natural enemy behavioural responses and the suitability of the invasive species as a prey/host resource. Invasion of exotic species in non-native environments may have several ecological effects, including consequences for the experience-mediated behavioural responses of indigenous foragers. Experience is usually thought to help resident species to buffer against negative impacts of new invasive species, including escaping from evolutionary traps. Here we hypothesized that the impact of foraging experience depends on whether an indigenous…
Creatinine and NT-ProBNP levels could predict the length of hospital stay of patients with decompensated heart failure.
2021
Heart failure (HF) is a clinical syndrome that causes high morbidity and mortality with a high number of admissions and sometimes prolonged admissions. This study aimed at assessing whether parameters detected during the first 24 h of admission may predict a prolonged hospital stay in patients admitted to hospital for decompensated HF.From January 2016 to December 2019, 2359 admissions of decompensated HF were recorded. In-hospital transfers,Univariate differences were found at admission in NT-ProBNP, creatinine, history of cardiac surgery, smoking and alcoholism, left and right ventricular ejection fraction, systolic blood pressure and heart rate. The ROC analysis showed significant areas …
Approches protéomiques en archéologie et héritage culturel : caractérisation de protéines anciennes préservées dans des coquilles de mollusques
2021
Archaeological mollusc shell artifacts and ecofacts are valuable sources to study past cultures and provide insights on how people exploited their environments. Mollusc shells were often used as raw materials to make personal ornaments and are abundantly found in archaeological sites. However, minute, heavily worked and/or fragmented shell ornaments are rarely identified at different taxonomic levels, due to limited availability of analytical approaches to determine taxon-specific (diagnostic) features. In recent years, proteomics, which exploits the high sensitivity of modern mass spectrometry techniques, has been successfully applied to the study of a variety of bioarchaeological remains,…
Hydroxypropyl Cellulose Films Filled with Halloysite Nanotubes/Wax Hybrid Microspheres
2021
The design of novel nanocomposite films based on hydroxypropyl cellulose (HPC) and wax/halloysite hybrid microspheres has been reported. In particular, we first prepared wax/clay Pickering emulsions which were characterized by thermogravimetric analysis and microscopy. SEM images allowed more detailed insights on the nanotubes disposition at the wax/water interface, acting as an outer stabilizing shell. Therefore, the cellulosic biopolymer was added, and it was found that HPC enhances the colloidal stability of the particles, preventing their coalescence and sedimentation. The preparation of the composite films was carried out by the solvent casting method, which enabled the development of …
Landelinus, l’auteur de la plaque-boucle mérovingienne au Christ de l’Apocalypse découverte à Ladoix-Serrigny (Côte-d’Or) serait-il saint Landeli…
2021
Cette note concerne l’exceptionnelle plaque-boucle au Christ cavalier de l’Apocalypse découverte à Ladoix-Serrigny et étudiée précédemment dans cette revue. Son objectif est de discuter l’hypothèse récemment émise selon laquelle saint Landelin, qui a vécu au VIIe siècle dans le nord de la Gaule, serait Landelinus, l’auteur de cet objet. Plusieurs arguments militent en faveur de cette interprétation qui nous paraît donc plausible, même si elle reste fragile. Il est également envisagé de localiser cette fabrication dans le prestigieux monastère de Luxeuil. Mais il s’agit là encore d’une hypothèse. This note concerns the exceptional buckle-plate to the Christ cavalier of the Apocalypse discove…
Early detection of SARS-CoV-2 infection cases or outbreaks at nursing homes by targeted wastewater tracking
2021
Objectives Near-source tracking of SARS-CoV-2 RNA in the sewage drains serving particular buildings may allow rapid identification of SARS-CoV-2 infection cases or local outbreaks. In this pilot study, we investigated whether this was the case for nursing homes (NH). Methods The study involved five NH (from A to E) affiliated to the Clínico-Malvarrosa Health Department, Valencia (Spain). These were nursing or mixed nursing/care homes of different sizes, altogether providing care for 472 residents attended by a staff of 309. Near-source sewage samples were screened for presence of SARS-CoV-2 RNA by RT-qPCR at least 5 days per week during the study period. SARS-CoV-2 RNA testing in nasopharyn…
Legal Texts and Juridical Practice in Byzantine Italy
2021
Italy was reannexed into the Byzantine empire precisely at the time when, in Constantinople, Justinian’s monumental corpus codified Roman juridical production and opened those regulations to a Byzantine interpretation, thereby paving the way for a legal system that would serve as the basis of Byzantine jurisprudence. While legal texts concerning Italy are limited in number, the manuscript tradition of legal books is copious. Furthermore, with respect to other areas of the empire, Italy, together with Egypt, is the best documented “peripheral” region, as far as juridical practice is concerned. This duality is due both to fortuitous archival circumstances and to the real feature of the Byzant…
Summer aggregation of common eagle ray, Myliobatis aquila (Chondrichthyes: Myliobatidae), in the Marine Protected Area of the Egadi Islands (southwes…
2021
Author(s): Grancagnolo, Desiree; Arculeo, Marco | Abstract: We report for the first time in Italian waters a periodic and frequent presence of a summer aggregation of common eagle ray Myliobatis aquila in the island of Marettimo (southwestern Tyrrhenian Sea), which is part of the Marine Protected Area of the Egadi Islands. These aggregation could be related to different phenomena such as reproduction, feeding or simply as a transit zone.
SMEs' heterogeneity at the extensive margin and within the intensive margin of trade
2021
In this paper, we contribute to the literature on firm-heterogeneity and trade, by looking not only at the firm-level determinants of trade participation (i.e. extensive margin) but also at differences between firms with different levels of trade intensity (i.e. intensive margin). Further, we compare firms that are born ‘local’ and display different scales of international exposure to firms that are born ‘global’, i.e. access international markets soon after their birth. Using a large World Bank dataset of SMEs from 112 countries and qualitative dependent variable models, our analysis uncovers the heterogeneity of SMEs not only at the extensive margin but also within the intensive margin of…
Differences in Immaterial Details: Dimensional Conversion and Its Implications for Protecting Digital Designs Under EU Design Law
2021
AbstractThe paper considers three main questions: the legal status of digital designs from the perspective of EU design law, whether the protection is tied to the reproduction of physical products, and whether the scope of protection covers dimensional conversion such as using a 3D design in 2D form or vice versa. There are two sets of views regarding dimensional conversion: the “abstract” and the “concrete” view. These two different attitudes towards the scope of protection influence the manner in which the protectability of digital designs is assessed. In the “abstract” protection, it would not matter whether a product only exists as a digital image and not as a physical shape. In the “co…
Applicability and safety of discontinuous ADVanced Organ Support (ADVOS) in the treatment of patients with acute-on-chronic liver failure (ACLF) outs…
2021
Background ADVanced Organ Support (ADVOS) is a novel type of extracorporeal albumin dialysis and holds promise to sustain liver function and recovery of patients with acute-on-chronic liver failure (ACLF). Previously, ADVOS was tested as continuous treatment for intensive care patients with liver failure. Data related to the applicability and safety as discontinuous treatment outside of ICU is not available. Aim Evaluation of ADVOS as discontinuous treatment for patients with ACLF outside intensive care unit and comparison with a matched historic cohort. Methods and results In this retrospective study, 26 patients with ACLF and the indication for renal replacement therapy related to HRS-AK…
Antitumoral activity of curcumin: an adjuvant therapeutic strategy
2021
Curcumin, an active substance contained in an Indian spice called turmeric or curcuma, is well known for its anti-inflammatory and antioxidant properties. In recent times, it was taken into account and studied as an antitumoral molecule, by relying on its interference on several biological mechanisms, such as the inhibition of inflammatory mediators, the enhancement of detoxifying enzymes’ action and processes of cell growth and proliferation. Studies show how the high dosage of curcumin in vitro inhibits colorectal tumor cells, pancreatic tumor cells, lung cancer cells and glioblastoma’s cells, interfering in signaling pathways as Wnt/β-catenin, NF-kB and PI3K/Akt and leading to cell cycle…
A Study of the Lack of Slow Magnetic Relaxation in Mononuclear Trigonal Bipyramidal Cobalt(II) Complexes
2021
Analysis of the differences in serve effectiveness between Billie Jean King Cup (former Fed Cup) and Davis Cup doubles tennis matches
2021
The doubles game has considerable relevance in professional tennis, especially in team competitions such as the Billie Jean King Cup (former Fed Cup) (BJKC) and the Davis Cup (DC). However, there are very few studies that have carried out quantitative notational analysis to provide information on the specific features of this tennis modality. The goal of this study was to analyse the differences in serve direction and effectiveness of male and female teams in matches played at BJKC and DC ties. A total of 29,207 serves; 7,578 of BJKC and 21,628 of DC matches were analysed. The data was obtained through the Hawk-Eye system. The results showed that with the first serve, both BJKC and DC team…
Detecting the Diffuse Supernova Neutrino Background in the future Water-based Liquid Scintillator Detector Theia
2021
A large-scale neutrino observatory based on water-based liquid scintillator (WbLS) will be excellently suited for a measurement of the diffuse supernova neutrino background (DSNB). The WbLS technique offers high signal efficiency and effective suppression of the otherwise overwhelming background from neutral-current interactions of atmospheric neutrinos. To illustrate this, we investigate the DSNB sensitivity for two configurations of the future Theia detector by developing the expected signal and background rejection efficiencies along a full analysis chain. Based on a statistical analysis of the remaining signal and background rates, we find that a rather moderate exposure of $190\text{ }…
Voice and authorial body in Juana Manso
2021
El estilo de Juana Manso fue calificado por Sarmiento como «escandaloso». Esa manera inequívoca de presentarse públicamente delimitó desde entonces un modo de existencia, de circulación y de funcionamiento de su figura autorial en el campo cultural argentino de mediados de siglo XIX. Este artículo se propone rastrear esta singular «puesta en escena» de la escritora como un dispositivo de enunciación que no se limita a sus textos, en la doble dimensión que ocupa, como autora y como actora de ese campo. ¿Cómo se construye, en esta puesta escena, su voz y su imagen?, ¿Cómo se difunde ese cuerpo de autora? En la conjunción de género y profesión, la función-Manso se concreta en un tono de escrit…
Early Tumor Size Reduction of at least 10% at the First Follow-Up Computed Tomography Can Predict Survival in the Setting of Advanced Melanoma and Im…
2021
Early tumor size reduction (TSR) has been explored as a prognostic factor for survival in patients with advanced melanoma in clinical trials. The purpose of this analysis is to validate, in a routine clinical milieu, the predictive capacity of TSR by 10% for overall survival (OS) and progression-free survival (PFS) and to compare its predictive performance with the RECIST 1.1 criteria.This retrospective study was approved by the local ethics committee. A total of 152 patients with both CT before immunotherapy initiation and at first response evaluation after immunotherapy initiation were included. Prior to statistical analysis, treatment response was trichotomized as follows: Complete respo…
Perspectives on Leadership in Early Childhood Education and Care Centers Through Community of Practice
2021
This article investigates early childhood education and care (ECEC) leadership through the concept of community of practice (COP). The focus is on ECEC leaders’ perceptions regarding their leadership during the educational changes taking place in the context of Finnish ECEC. The purpose is to increase understanding of how leaders see themselves in relation to the ECEC multi professional working community and practices of distributed leadership. The data are five focus group interviews of ECEC leaders analyzed with directed content analysis within the theoretical frame of domain, practice, and community forming the core of COP in Lave and Wenger. The results show how all three COP component…
Effects of Functional Strength Training on Functional Movement and Balance in Middle-Aged Adults
2021
Functional movement deficiencies cause falls and injuries in adults. Functional strength training (FST) is emerging as a new training method for athletes, middle-aged and older adults, to improve functional movement: The present study was conducted in order to investigate the effects of FST on balance and functional movement in healthy and independent middle-aged adults. The sample for this study consisted of 46 physically active individuals (24 female and 22 male). A total of 46 subjects were divided based on randomly into the functional strength training (FST) group (n = 26) aged: 51.55 ± 3.73 years; height: 168.69 ± 8.8 cm; body mass: 75.88 ± 12.18; and traditional s…