showing 36 of ~574560 from 574555 documents
Additional file 1 of Blood and skeletal muscle ageing determined by epigenetic clocks and their associations with physical activity and functioning
2021
Additional file 1: Within-pair correlations in age acceleration in blood and in muscle. Additional file 2: Associations between DNAmAge age acceleration estimates and body composition and physical activity in blood. Additional file 3: Sensitivity analyses related to twin pair discordance in body mass index.
Konservative urogynäkologische Therapie
2021
Die Pessar-Therapie ist ein einfaches und schnell verfugbares Verfahren zur Reposition eines Genitalprolaps. Voraussetzung fur einen erfolgreichen Einsatz sind lediglich eine ausreichende Scheidenlange sowie ein suffizienter Beckenbodentonus. Die haufigsten Komplikationen umfassen u. a. eine Vaginitis, Kolpitis, Erosionen oder auch eine okkulte Belastungsinkontinenz. Dennoch sind die Komplikationen uberwiegend reversibel und lassen sich durch regelmasige Kontrollen oftmals vermeiden oder zuverlassig behandeln. Schwerwiegende Komplikationen sind zumeist durch Anwendungsfehler aufgrund unregelmasiger Pessar-Wechsel oder fehlender Kontrolluntersuchungen bedingt.
Clinical utility of antigen carbohydrate 125 for planning the optimal length of stay in acute heart failure.
2021
BACKGROUND: The optimal length of stay (LOS) in patients hospitalized for acute heart failure (AHF) remains controversial. Plasma antigen carbohydrate 125 (CA125) has emerged as a reliable proxy of congestion. We aimed to evaluate whether there is a differential impact of LOS on the risk of 6-month AHF readmission across CA125 levels. METHODS: This is a retrospective study that included 1,387 patients discharged for AHF in two third-level centers. CA125 was measured 48±24h after admission. The association between CA125 and LOS with the risk of subsequent AHF readmission at 6 months was analyzed by Cox regression analysis accounting for death as a competing event. RESULTS: The median (IQR) a…
Por sus obras los conoceréis. Documentos de perpetrador y voces de víctimas en Retratos de identificação (Anita Leandro, 2014)
2021
espanolEn los ultimos anos, el estudio de los perpetradores de violencia de masas ha crecido sustancialmente en publicaciones academicas, museos, memorias y cobertura mediatica. Lo ha hecho cada vez con menos dependencia respecto a los influyentes y muy avanzados Holocaust Studies. Ademas, los horizontes de la investigacion se han ampliado desde las personalidades y la maquinaria de destruccion al estudio mas cercano de los documentos, objetos y mirada de los perpetradores. Es en este dominio donde se inscribe un film como Retratos de identificacao de Anita Leandro (2014), film que, nacido de la investigacion historica, se propone reescribir mediante el uso de la composicion y el montaje lo…
Additional file 12 of Development and validation of prediction model to estimate 10-year risk of all-cause mortality using modern statistical learnin…
2021
Additional file 12. The distribution of survival probabilities estimated based on 13 variables included in the model in the development and validation cohorts.
Pharmacogenetics in Neuroblastoma: What Can Already Be Clinically Implemented and What Is Coming Next?
2021
Pharmacogenetics is one of the cornerstones of Personalized Precision Medicine that needs to be implemented in the routine of our patients’ clinical management in order to tailor their therapies as much as possible, with the aim of maximizing efficacy and minimizing toxicity. This is of great importance, especially in pediatric cancer and even more in complex malignancies such as neuroblastoma, where the rates of therapeutic success are still below those of many other types of tumors. The studies are mainly focused on germline genetic variants and in the present review, state of the art is presented: which are the variants that have a level of evidence high enough to be implemented in the c…
Nietzsche i l'escepticisme : assaig d'aclariment d'una pretesa contradicció
2021
S'ha afirmar sovim que en marhia de teoria del coneixemem, Nietzsche és un esckptic. En aquest anide es fa un acurat repil.s de !'obra nictncheana a la cerca de les sentencies en pro o en contra de l'escepticismc, on les posicions en contra d'aqucst són especialment abundases en contradicció amh aquclles intcrprctacions. En el curs d'aqucst recorregut s'esbossa el conccpte nietzscheà de filosofia i la diferCncia entre aquesta i la ciCncia. La tesi final és que Nietzsche considera l'escepticismc una condició necesüria, perO no suficient, de la vcrtadcra filosofia. la filosofia sobirana i disciplinadora de la cultura. Així es dissoldrJ. la contradicció entre les interpretacions de !'autor com…
Changes in food habits amongst Norwegian adolescents in 2016 and 2019 according to gender and socioeconomic status
2021
Background: Monitoring dietary habits is important in order to identify risk groups and as a basis for targeted public health initiatives. Objective: To study trends in consumption of selected foods and beverages from 2016 to 2019 amongst Norwegian adolescents according to gender and parental education. Design: Repeated cross-sectional study amongst 25,996 adolescents, aged 14–17 years old. Consumption of selected food and beverages was measured by an online food frequency questionnaire and general linear models were applied to estimate changes in dietary habits. Results: Between 2016 and 2019, we observed a reduced frequency of consumption of vegetables (from 4.7 to 4.4 times/week), fruit …
The time course of processing handwritten words: An ERP investigation
2021
Available online 25 June 2021. Behavioral studies have shown that the legibility of handwritten script hinders visual word recognition. Furthermore, when compared with printed words, lexical effects (e.g., word-frequency effect) are magnified for less intelligible (difficult) handwriting (Barnhart and Goldinger, 2010; Perea et al., 2016). This boost has been interpreted in terms of greater influence of top-down mechanisms during visual word recognition. In the present experiment, we registered the participants’ ERPs to uncover top-down processing effects on early perceptual encoding. Participants’ behavioral and EEG responses were recorded to high- and low-frequency words that varied in scr…
Boolean Networks: A Primer
2021
Abstract Autism Spectrum Disorders (ASDs) stand out as a relevant example where omics-data approaches have been extensively and successfully employed. For instance, an outstanding outcome of the Autism Genome Project relies in the identification of biomarkers and the mapping of biological processes potentially implicated in ASDs’ pathogenesis. Several of these mapped processes are related to molecular and cellular events (e.g., synaptogenesis and synapse function, axon growth and guidance, etc.) that are required for the development of a correct neuronal connectivity. Interestingly, these data are consistent with results of brain imaging studies of some patients. Despite these remarkable pr…
Developing design knowledge and a conceptual model for virtual reality learning environments
2021
This chapter focuses on applying design science research for virtual reality learning environment (VRLE) design processes. Six selected case studies are presented in the context of VRLEs. The case selections were analyzed in terms of their contributions to design knowledge. The objective of this book chapter is twofold: 1) for researchers, the design knowledge contributions of case studies are highlighted for future reference, and 2) for developers and practitioners, design principles are presented for the development of VRLEs. The final outcome of the present study is a conceptual model describing the current design knowledge in the field of VRLEs and identifying the research gaps that sho…
Kihon Checklist to assess frailty in older adults: Some evidence on the internal consistency and validity of the Spanish version
2021
Aim The aim of this study was to assess the internal consistency, hypothesis testing and criterion-related validity of the Spanish versions of the Kihon Checklist (KCL) - the original 25-item and reduced 15-item versions - for screening frailty in community-dwelling older adults. Methods A cross-sectional study was carried out between March and September 2018 in Valencia province (Spain). A sample of 251 participants was recruited. Construct validity was assessed using four different frailty instruments, and alternative measures corresponding to the KCL domains (handgrip strength, gait speed, the Short Physical Performance Battery, skeletal muscle mass index, physical activity level, functi…
Health(care) in the Crisis: Reflections in Science and Society on Opioid Addiction
2021
Opioid abuse and misuse have led to an epidemic which is currently spreading worldwide. Since the number of opioid overdoses is still increasing, it is becoming obvious that current rather unsystematic approaches to tackle this health problem are not effective. This review suggests that fighting the opioid epidemic requires a structured public health approach. Therefore, it is important to consider not only scientific and biomedical perspectives, but societal implications and the lived experience of groups at risk as well. Hence, this review evaluates the risk factors associated with opioid overdoses and investigates the rates of chronic opioid misuse, particularly in the context of chronic…
The changing scenario of hepatocellular carcinoma in Italy: an update
2021
Background and aims: Epidemiology of hepatocellular carcinoma (HCC) is changing in most areas of the world. This study aimed at updating the changing scenario of aetiology, clinical presentation, management and prognosis of HCC in Italy during the last 15 years. Methods: Retrospective analysis of the Italian Liver Cancer (ITA.LI.CA) database included 6034 HCC patients managed in 23 centres from 2004 to 2018. Patients were divided into three groups according to the date of cancer diagnosis (2004-2008, 2009-2013 and 2014-2018). Results: The main results were: (i) a progressive patient ageing; (ii) a progressive increase of non-viral cases and, particularly, of ‘metabolic’ and ‘metabolic + alc…
La toponimia como recurso didáctico para la enseñanza de la Geografía. Una propuesta a partir de tres salidas de campo en la Huerta de València (Espa…
2021
El objetivo de este trabajo es presentar una propuesta didáctica para el profesorado de Educación Primaria sobre el uso de la toponimia a partir de 3 salidas de campo en la Huerta de València (España). Ante la falta de trabajos sobre educación, toponimia y geografía en el área de estudio, este trabajo aportará significativamente al conocimiento sobre la didáctica de la geografía con el uso de salidas de campo en relación con la toponimia, pero también servirá de paradigma para la comunidad docente, ya que podrá aplicarlo a su territorio de referencia. This research makes a didactic proposal to Primary School teachers regarding the use of toponymy, based upon three field trips to Huerta de V…
Poszukiwanie własnej tożsamości przez młodych Łemków
2021
Katalog fauny Ojcowskiego Parku Narodowego: wydano z okazji 65. rocznicy utworzenia Ojcowskiego Parku Narodowego 1956-2021
2021
Katalog fauny Ojcowskiego Parku Narodowego – tom 1. zawiera opracowanie większości grup bezkręgowców i wszystkich kręgowców. W katalogu uwzględniono dane z literatury oraz wszelkie dostępne informacje o występujących tu gatunkach, stwierdzonych w czasie badań własnych autorów opracowania oraz zgromadzonych w zbiorach muzealnych. W opracowaniu podano 6051 gatunków zwierząt; w tym 372 nowych dla Ojcowskiego P.N., najwięcej z rzędu muchówek (tabela). Wśród nich są dwie muchówki nie wykazywane dotąd z terenu Polski: ćmianka – Clogmia albipunctata z rodziny Psychodidae i Bicellaria vana z rodziny Hybotidae. Kilkadziesiąt nowych dla Parku gatunków podano z rzędu chrząszczy oraz chruścików. Do 197…
Evropská ochrana přírody v kontextu ekoturistiky v česko-polském příhraničí
2021
Rodzina - rodzicielstwo - odpowiedzialność. Perspektywa pedagogiki społecznej
2021
Analysis of the Economic Potential Trough Biochar Use for Soybean Production in Poland
2021
Soybean (Glycine max L.) is one of the most important crops grown globally. Biochar has been proposed as an alternative to aid sustainable soybean production. However, comprehensive studies that include both the economic aspects of soybean production and biochar are scarce. Poland, with an economy largely based on agriculture, is an interesting case to investigate the cost-effectiveness of using biochar in soybean production. We show that the use of biochar at rates of 40, 60 and 80 t/ha is unprofitable compared with a traditional soil amendment, such as NPK fertilization. The breakeven price for biochar to be economically viable should be USD 39.22, USD 38.29 and USD 23.53 for 40, 60 and 8…
Pokoleniowy potencjał polityki
2021
Wykorzystywanie seksualne małoletnich przez duchownych w kinematografii: nierozpoznane znaki czasu
2021
Contemporary theology applies the old notion of loci theologici also to media and film. It is not only films that are directly religious (biblical, hagiographies, etc.) that have theological significance, but also those that take up topics related to the Church in a critical way. Therefore, one should be aware of the appearance of successive films, documentaries and feature films, which raise the issue of sexual abuse against the youngest (paedophilia) also in the Church. The article presents the most important films, whose authors present the perpetrators of paedophilia, the mechanisms leading to its concealment and silence not only in the Church, but also in the media and society, as well…
Chorzów. T. 4, W II Rzeczypospolitej i w latach wojny (1922-1945)
2021
"Minulla täytyy olla mielessä hallittu kaaos, jotta tekstiä syntyy" : Leevi Lehdon Päivä yhdenpäivänromaanina
2021
Kuoropedagogiikkaa uusin silmin : tavoitteena osallisuus ja taiteellinen taso
2021
CMC is more than a measure of corticospinal tract integrity in acute stroke patients
2021
In healthy subjects, motor cortex activity and electromyographic (EMG) signals from contracting contralateral muscle show coherence in the beta (15-30 Hz) range. Corticomuscular coherence (CMC) is considered a sign of functional coupling between muscle and brain. Based on prior studies, CMC is altered in stroke, but functional significance of this finding has remained unclear. Here, we examined CMC in acute stroke patients and correlated the results with clinical outcome measures and corticospinal tract (CST) integrity estimated with diffusion tensor imaging (DTI). During isometric contraction of the extensor carpi radialis muscle, EMG and magnetoencephalographic oscillatory signals were re…
Thomas Bernhard: Halvallasyöjät – Wittgenseinin veljenpoika
2021
Kirja-arvio teoksesta Thomas Bernhard: Halvallasyöjät – Wittgenseinin veljenpoika. Suom. Tarja Roinila, Teos 2020 nonPeerReviewed
Setting Individual Goals for Pupils with Profound Intellectual and Multiple Disabilities : Engaging in the Activity Area-Based Curriculum Making
2021
The activity area-based curriculum model (AACM) is used in the Finnish basic education to support pupils—most of whom have profound intellectual and multiple disabilities (PIMD)—who could benefit more from skills that advance independent life coping. Existing studies have concentrated mainly on the Individual Education Plan (IEP) goal-setting process for pupils with milder disabilities than PIMD and have consistently demonstrated significant barriers in the process. This study explores the collaborative IEP goal-setting process for pupils with the AACM. Sixty-five Finnish special education teachers using the AACM participated in the study. Semi-structured interviews were analysed with thema…
Outdoor activities and motor development in 2–7-year-old boys and girls
2021
Problem Statement: Parents of young children favor indoor activities for their children, because staying inside supports comfortable daily routines in the family timetable, safety issues and clothing. However, playing outdoors supports children’s development, offering multiple challenges to overcome and the possibility to learn new skills. Approach: Based on Gibson’s theory of affordances (1977), outdoors can be seen as an excellent learning environment for children to reach the zone of proximal development (Vygotsky, 1987). Purpose: This paper describes Finnish nature and four seasons as an environment to support children’s motor development and inspire outdoor playing. The Skilled kids pa…
Design og bruk av modelleringsoppgaver i klasserommet : En forskningsstudie om hvordan en designer modelleringsoppgaver
2021
Master's thesis in Mathematics education (MA502) Modeling is a mathematical skill that connects mathematics to the real world. Mathematical modeling has been a part of the new curriculum, LK20. Modeling will therefore get an extra attention in the teaching the mathematical competence of modeling. This is challenging for both teachers and students, and one of the reasons that it has not been prioritized in teaching mathematics. To teach modeling it requires good tasks to use in the classroom that challenge students on all level. In this study I investigated teaching modeling in the classroom with the research question: (1) How to model task that students can feel relevant and meaningful? (2)…
Investigating Motion Sickness in Racing Simulators using Virtual Reality and a Motion Platform
2021
Master's thesis in Multimedia and educational technology (MM506) Motion sickness has been a downside of virtual reality since its beginning. According to the "Sensory conflict" theory, simulation sickness and cybersickness often occurs due to the feeling of self-motion. This thesis aimed to investigate if a motion platform could mitigate simulation sickness. By using commercial available motion platform and virtual reality headset, the experiment had three conditions, one without any added motion, one with motion and the last with increased motion. Participants were put in a complete racing set to drive an Edge 6D motion simulator in Asseto Corsa. The participants drove a high-speed car for…
“An unexploited potential” LifeLab Food and Health: Assessment and Development of Teaching and Learning Practices in the Norwegian School Subject Foo…
2021
Adhering to a healthy diet is key to a healthy life. Furthermore, investing in child and adolescent health has been highlighted as particularly important since it benefits the individual both now and long-term, as well as future generations. Based on this, schools have been identified as a crucial arena to reach this age group. In Norway, the school subject termed Food and Health (FH) educates students in food and nutrition and how this is related to health. Still, there is concern students are not acquiring the competencies highlighted in the curriculum since the number of formally qualified in FH is the lowest among all school subjects. Also, FH classes today primarily focus on cooking an…
Kritiskās domāšanas attīstība vecākajā pirmsskolas vecumā
2021
Darba autore: Liene Gribuste Bakalaura darba tēma: Kritiskās domāšanas attīstība vecākajā pirmsskolas vecumā Studiju programma: Profesionālā bakalaura studiju programma ‘’Pirmsskolas un sākumskolas skolotājs’’ Darba zinātniskais vadītājs: Docente Dr. Paed. Inese Freiberga Bakalaura darbā tiek pētīts / analizēts: Vecākā pirmsskolas vecuma bērna kritiskās domāšanas attīstība. Darba mērķis: Izpētīt kritiskās domāšanas attīstības iespējas vecākajā pirmsskolas vecumā, sniedzot bērniem iespējas pašiem spriest un analizēt, pieņemt lēmumus un secināt sava lēmuma rezultātu, kā arī izmantojot problēmrisināšanas metodi. Darba uzdevumi: 1. Pētīt pedagoģijas un psiholoģijas zinātnieku teorijas par kriti…
Ritma vingrinājumu izmantošana fonemātiskās uztveres pilnveidei 5 - 6 gadus veciem bērniem
2021
Maģistra darba nosaukums: „Ritma vingrinājumu izmantošana fonemātiskās uztveres pilnveidē 5 – 6 gadus veciem bērniem”. Darba autore: Rainida Segliņa Darba zinātniskā vadītāja: Mg. paed. Egija Laganovska Darba saturs: 68 lappuses, 16 attēli, 6 tabulas, 30 pielikumi. Pētījuma mērķis: veikt teorētisko izpēti un praktiski pārbaudīt, kā ar ritma vingrinājumu palīdzību pilnveidot fonemātisko uztveri 5 – 6 gadus veciem bērniem. Pētījuma jautājums: vai ritma vingrinājumu izmantošana logopēdiskajās nodarbībās pilnveido fonemātisko uztveri 5 – 6 gadus veciem bērniem? Pētījuma teorētiskajā daļā darba autore pēta un analizē zinātnisko un metodoloģisko literatūru. Darba autore analizē un apraksta pirmss…
Krustotās un nekrustotās stereoredzes izmaiņas pēc LASIK operācijas
2021
Maģistra darbs uzrakstīts angļu valodā uz 37 lappusēm. Tas satur 10 attēlus, 9 tabulas un darbam ir 49 atsauces uz literatūras avotiem. Pētījuma mērķis bija novērtēt krustotās un nekrustotās disparitātes stereoredzes asumu pirms redzes refraktīvās operācijas, divus, četrus un sešus mēnešus pēc operācijas. Pētījumā piedalījās 102 acu klīnikas pacienti – 65 sievietes un 37 vīrieši vecumā no 19 līdz 45 gadiem. Visiem bija miopija vai miopija ar astigmatismu. Jaunais izveidotais izkliedēto punktu globālais stereoredzes datorizētais tests dod iespēju novērtēt abus disparitātes veidus. Rezultātu analīzē tika secināts, ka nav novērojamas statistiski būtiskas izmaiņas stereoredzes asumā pirms un pē…
Pilnās pārlases metode skolas kursā un matemātikas olimpiādēs 5.-12. klasēm
2021
Bakalaura darbā „Pilnās pārlases metode skolas kursā un matemātikas olimpiādēs 5. – 12. klasēm”, analizējot literatūru, izglītības standartu, olimpiāžu uzdevumus un Rīgas Centra humanitārās vidusskolas 5. – 12. klašu skolēnu rezultātus darba autora izveidoto uzdevumu komplektu risināšanā, tika aprakstītas pilnās pārlases metodes izmantošanas iespējas skolas kursā un matemātikas olimpiādēs. Darbā ir piecas nodaļas: 1. nodaļā aplūkota metodes izcelsme un salīdzinātas dažādu avotu piedāvātās pilnās pārlases metodes definīcijas; 2. nodaļā aprakstīta pilnās pārlases metodes loma izglītības standartā un matemātikas olimpiādēs; 3. nodaļā apkopoti uzdevumi un to risinājumi ar pilnās pārlases metodi…