The familial relationship between panic disorder and unipolar depression

1995

Abstract This controlled family study explores (1) whether panic disorder and unipolar depression share familial factors, and (2) whether the co-occurrence of lifetime diagnoses of panic disorder and unipolar depression in individuals defines a distinct diagnostic subtype in terms of familial aggregation. To be most informative, the familial lifetime prevalence rates for panic disorder and unipolar depression have to be determined in a set of four proband groups: 78 patients with unipolar depression and panic disorder, 121 patients with unipolar depression alone (no panic disorder), 81 patients with panic disorder alone (no unipolar depression), and 109 control probands sampled in the gener…

Properties of modified hepatitis B virus surface antigen particles carrying preS epitopes

1995

The current hepatitis B virus (HBV) vaccines contain the small (S) and middle (M) viral envelope proteins in particulate form but lack the large (L) protein. Although these particles elicit protective immunity to HBV, inclusion of the immunogenic preS1 region of the L protein may enhance their efficacy. To present preS1-derived epitopes on secretable subviral particles we rearranged the HBV envelope ORF by fusing part or all of the preS1 region to either the N or C terminus of the S protein. Fusion of the first 42 residues of preS1 to either site allowed efficient secretion of the modified particles and rendered the linked sequence accessible at the surface of the particle. Conversely, fusi…

Chlorinated cymenes in effluents of two Finnish pulp mills in 1990–1993

1995

Abstract Seven chlorocymenes (CYMS) and 2,3,6-trichloro-p-cymenene (236CYMD) were determined in effluents of biological purification plants of two Finnish pulp mills during the years 1990–1993. Both pulp mills changed their bleaching process and consequently, a steep decreasing trend in emitted amounts of the studied compounds was noticed.

Analysis of neural elements in head-mutant Drosophila embryos suggests segmental origin of the optic lobes.

1995

We describe the development of 20 sensory organs in the embryonic Drosophila head, which give rise to 7 sensory nerves of the peripheral nervous system (PNS), and 4 ganglia of the stomatogastric nervous system (SNS). Using these neural elements and the optic lobes as well as expression domains of the segment polarity gene engrailed in the wild-type head of Drosophila embryos as markers we examined the phenotype of different mutants which lack various and distinct portions of the embryonic head. In the mutants, distinct neural elements and engrailed expression domains, serving as segmental markers, are deleted. These mutants also affect the optic lobes to various degrees. Our results suggest…

The Jordan-Hölder theorem and prefrattini subgroups of finite groups

1995

by A. BALLESTER-BOLINCHES and L. M. EZQUERRO(Received 26 January, 1994)Introduction. All groups considered are finite. In recent years a number ofgeneralizations of the classic Jordan-Holder Theorem have been obtained (see [7],Theorem A.9.13): in a finite group G a one-to-one correspondence as in the Jordan-Holder Theorem can be defined preserving not only G-isomorphic chief factors but eventheir property of being Frattini or non-Frattini chief factors. In [2] and [13] a newdirection of generalization is presented: the above correspondence can be defined in sucha way that the corresponding non-Frattini chief factors have the same complement(supplement).In this paper we present a necessary a…

Modelling and prediction of retention in high-performance liquid chromatography by using neural networks

1995

Multi-layer feed-forward neural networks trained with an error back-propagation algorithm have been used to model retention behaviour of liquid chromatography as a function of the composition of the mobile phases. Conventional hydro-organic and micellar mobile phases were considered. Accurate retention modelling and prediction have been achieved using mobile phases defined by two, three and four parameters. With micellar mobile phases, the parameters involved included the concentrations of surfactant and organic modifier, pH and temperature. It is shown that neural networks provide a competitive tool to model varied inherent nonlinear relationships of retention behaviour with respect to the…

First observations of Pontecorvo reactions with a recoiling neutron

1995

We report the first observations of Pontecorvo reactions of the type ¯pd →Xn. We fully reconstruct the outgoing meson and, for antiprotons stopped in liquid deuterium, we measure: BR(¯pd→π0)=(7.03±0.72)×10−6, BR(¯pd→ηn)=(3.19+0.48)×10−6, BR(¯pd→ωn)=(22.8+4.1)×10−6, BR(¯pd→η′n)14×10−6 (at 95% confidence level). Assuming charge independence, our result for¯ pd→π0n is compatible with measurements of the only other observed Pontecorvo reaction ¯pd → π−p. The experimental ratios between the above branching ratios are in fair agreement with both the statistical model and dynamical two-step models (assumingN¯ N annihilation into two mesons, with subsequent absorption of one meson on the remaining …

A new measurement of the spin-dependent structure function $g_{1}(x)$ of the deuteron

1995

Abstract We present a new measurement of the spin-dependent structure function g 1 d of the deuteron in deep inelastic scattering of 190 GeV polarised muons on polarised deuterons, in the kinematic range 0.003 x 2 Q 2 2 . This structure function is found to be negative at small x . The first moment Γ 1 d =∫ 0 1 g 1 d d x evaluated at Q 0 2 = 10 GeV 2 is 0.034 ± 0.009 (stat.) ± 0.006 (syst.). This value is below the Ellis-Jaffe sum rule prediction by three standard deviations. Using our earlier determination of Γ 1 p , we obtain Γ 1 p − Γ 1 n = 0.199 ± 0.038 which agrees with the Bjorken sum rule.

false

1995

En el presente trabajo se estudian dos nuevos yacimientos descubiertos recientemente en el area de Crevillente (Alicante), los cuales han proporcionado restos de macromamiferos. Ambos afloramientos, denominados Crevillente 15 y Crevillente 16, se encuentran proximos entre si, y sus respectivas asociaciones fosiles son muy semejantes, indicando una edad Turoliense medio (MN12). Desde el punto de vista geologico, se ha precisado la posicion estratigrafica de las localidades con respecto a Crevillente 2, que es el yacimiento mas importante de los conocidos en esta area. Ademas, tambien se ha descrito la estratigrafia de detalle del tramo en que se encuentran los dos niveles estudiados. Por otr…

Homeobox-containing gene transiently expressed in a spatially restricted pattern in the early sea urchin embryo

1995

In the sea urchin embryo, the lineage founder cells whose polyclonal progenies will give rise to five different territories are segregated at the sixth division. To investigate the mechanisms by which the fates of embryonic cells are first established, we looked for temporal and spatial expression of homeobox genes in the very early cleavage embryos. We report evidence that PlHbox12, a paired homeobox-containing gene, is expressed in the embryo from the 4-cell stage. The abundance of the transcripts reaches its maximum when the embryo has been divided into the five polyclonal territories--namely at the 64-cell stage--and it abruptly declines at later stages of development. Blastomere dissoc…

Study of the Unstable NucleusL10iin Stripping Reactions of the Radioactive ProjectilesB11eandL11i

1995

Reactions of the halo systems Be-11 and Li-11 (at 460 and 280 MeV/nucleon) with a carbon target demonstrate that (n + Li-9) has an (unbound) l = 0 ground state very close to the threshold. The neutron halo of Li-11 has appreciable (1s(1/2))(2) and (0p(1/2))(2) components.

<title>Electrochromism of W-oxide-based films: some theoretical and experimental results</title>

1995

We survey some recent work related to electrochromic W-oxide-based thin films. The electronic structure of cubic (perovskite) WO3 and HWO3 was calculated from first principles. It was found, among other things, that hydroxide formation was energetically favored. Experimental studies were made on films prepared by reactive magnetron sputtering in Ar + O2 with and without CF4 addition and substrate bias. Structural studies by atomic force microscopy, x-ray diffraction, infrared reflectance spectroscopy, and Raman spectroscopy indicated that the electron bombardment associated with a positive substrate bias led to grain growth and partial crystallization while maintaining a high density of W e…

Comparison of empirical leaf photosynthesis and stomatal conductance models

1995

National audience

Mapping the cell binding site on high molecular weight kininogen domain 5.

1995

Investigations mapped the region(s) on the light chain of high molecular weight kininogen (HK) that participates in cell binding. Sequential and overlapping peptides of domain 5 (D5H) were synthesized to determine its cell binding site(s). Three peptides from non-overlapping regions on D5H were found to inhibit biotin-HK binding to endothelial cells. Peptides GKE19 and HNL 21 weakly inhibited biotin-HK binding with IC50 of 792 and 215 microM, respectively. Peptide HKH20 inhibited biotin-HK binding with an IC50 of 0.2 microM. Two peptides, GGH18 and HVL24, which overlapped HKH20, also inhibited biotin-HK binding to endothelial cells with IC50 values of 108 and 0.8 microM, respectively. Bioti…

Purification and characterization of two exopolyphosphatases from the marine sponge Tethya lyncurium

1995

Abstract Two exopolyphosphatases (exopolyphosphatase I and II; EC 3.6.1.11) which release orthophosphate from inorganic polyphosphates have been detected and purified for the first time from a marine sponge, Tethya lyncurium . Exopolyphosphatase I has a molecular mass of 45 kDa, a pH optimum of 5.0 and does not require divalent cations for activity, while exopolyphosphatase II has a molecular mass of 70 kDa, a pH optimum of 7.5 and displays optimal activity in the presence of Mg 2+ ions. Final purification of the enzymes could be achieved by affinity chromatography on polyphosphate-modified zirconia. The mode of action of both enzymes was found to be processive. Orthophosphate is the sole p…

The dnaK operon of Streptomyces coelicolor encodes a novel heat-shock protein which binds to the promoter region of the operon

1995

Transcriptional studies have demonstrated that the dnaK gene of Streptomyces coelicolor A3(2) is contained within a 4.3 kb operon. The operon is transcribed from a single (transiently) heat-inducible promoter, dnaKp, that resembles the typical vegetative (sigma 70-recognized) eubacterial consensus promoter sequence. dnaK transcription was found to be heat-inducible at all stages of development in surface-grown cultures. In addition, at the normal growth temperature of 30 degrees C, dnaK transcript levels were shown to vary at different stages of development, being more abundant in young germinating cultures and in mycelium undergoing sporogenesis. The nucleotide sequence of the dnaK operon …

Developmental control of the heat-shock stress regulon in Streptomyces coelicolor

1995

In the differentiating eubacterium Streptomyces coelicolor, nutritional imbalances activate a developmental programme which involves the heat-shock stress regulon. In liquid batch cultures, the growth curve could be separated into four components: rapid growth 1 (RG1), transition (T), rapid growth 2 (RG2) and stationary (S). Patterns of gene expression in cultures subjected to heat shock in various phases were recorded on two-dimensional gels and analysed using advanced statistical methods. The responses of all heat-shock proteins (HSPs) were highly dependent upon the growth phase, thus demonstrating that the four phases of growth were physiologically distinct. For many HSPs, the levels of …

Screening of long-range leptonic forces by cosmic background neutrinos.

1995

The absence of dispersion effects of the SN~1987A neutrino pulse has been used to constrain novel long-range forces between neutrinos and galactic baryonic or non-baryonic matter. If these forces are mediated by vector bosons, screening effects by the cosmic neutrino background invalidate the SN~1987A limits and other related arguments.

Conserved alternative splicing in the 5'-untranslated region of the muscle-specific enolase gene. Primary structure of mRNAs, expression and influenc…

1995

We report here the isolation and characterization of cDNAs covering the 5'-end region of mouse and rat mRNAs that encode the beta or muscle-specific isoform of the glycolytic enzyme enolase. As previously determined for humans, two classes of beta-enolase transcripts with distinct sequences in their 5'-untranslated regions are present in both mouse and rat muscles. A mechanism of alternative splicing, conserved from mouse to man, generates the two forms of mRNA. Secondary-structure predictions indicated that, in all cases, a more stable secondary structure could exist in the 5' end of the message with the longer leader. In vitro transcripts containing defined human or mouse 5'-untranslated …

Self‐consistent intermediate Hamiltonians : A coupled cluster type formulation of the singles and doubles configuration interaction matrix dressing

1995

This paper presents a new self‐consistent dressing of a singles and doubles configuration interaction matrix which insures size‐consistency, separability into closed‐shell subsystems if localized molecular orbitals (MOs) are used, and which includes all fourth order corrections. This method yields, among several schemes, a reformulation of the coupled cluster method, including fully the cluster operators of single and double excitations, and partially those of the triples (Bartlett’s algorithm named CCSDT‐1a). Further improvement can be easily included by adding exclusion principle violating corrections. Since it leads to a matrix diagonalization, the method behaves correctly in case of nea…

The septal complex of the telencephalon of the lizardPodarcis hispanica. I. chemoarchitectonical organization

1995

In this paper we study the septal complex architecture in the lizard Podarcis hispanica (Lacertidae). Histochemical and immunohistochemical techniques were used to define the distribution of zinc (Timm stain), acetyl cholinesterase (AChase), gamma-aminobutyric acid (GABA), tyrosine hydroxylase (TH), dopamine (DA), serotonin (5-HT), and two neuropeptides: leu-enkephalin (L-ENK) and substance P (SP). These reactions delineate a coherent map of nine septal nuclei that are named with a topographical nomenclature: anterior, lateral, ventromedial, medial, dorsolateral, ventrolateral, and dorsal septal nuclei, nucleus septalis impar, and nucleus of the posterior pallial commissure. The anterior se…

IS MEANING WITHOUT ACTUALLY EXISTING REFERENCE NATURALIZABLE?

1995

Parity violating pion electroproduction off the nucleon

1995

Parity violating (PV) contributions due to interference between $\gamma$ and $Z^0$ exchange are calculated for pion electroproduction off the nucleon. A phenomenological model with effective Lagrangians is used to determine the resulting asymmetry for the energy region between threshold and $\Delta(1232)$ resonance. The $\Delta$ resonance is treated as a Rarita-Schwinger field with phenomenological $N \Delta$ transition currents. The background contributions are given by the usual Born terms using the pseudovector $\pi N$ Lagrangian. Numerical results for the asymmetry are presented.

Ernesta Foldāta vēstule draugiem LU Bioloģijas fakultātē 1995. gada 8. augustā

1995

Ernesta Foldāta vēstule draugiem Latvijas Universitātes Bioloģijas fakultātē, kurā viņš raksta par profesoru Edgaru Rutki un viņas sievas slimību un nāvi, savas ģimenes locekļu veselības stāvokļiem, grūto ekonomisko stāvokli Venecuēlā, dēlu grūtībām uzņēmuma vadīšanā, savu grāmatu izdošanu. Beigās novēlējumi un paraksts. Kopija vēstulei, kas drukāta mašīnrakstā uz vienas lapas. Glabājas Latvijas Universitātes Muzeja Botānikas un mikoloģijas kolekciju krājumā.

Leucine-58 in the putative 5th helical region of human interleukin (IL)-6 is important for activation of the IL-6 signal transducer, gp130

1995

A model of the tertiary structure of human IL-6, derived from the crystal-structure of granulocyte-colony stimulating factor, reveals a 5th helical region in the loop between the first and second alpha-helix. To investigate the importance of this region for biological activity of IL-6, residues Glu-52, Ser-53, Ser-54, Lys-55, Glu-56, Leu-58, and Glu-60 were individually replaced by alanine. IL-6.Leu-58Ala displayed a 5-fold reduced biological activity on the IL-6 responsive human cell lines XG-1 and A375. This reduction in bioactivity was shown to be due to a decreased capacity of the mutant protein to trigger IL-6 receptor-alpha-chain-dependent binding to the IL-6 signal transducer, gp130.

Determination of sulphonamides in human urine by azo dye precolumn derivatization and micellar liquid chromatography

1995

Abstract A high-performance liquid chromatographic method for the determination of sulphonamides in urine is reported. The drugs (sulphadiazine, sulphaguanidine, sulphamethizole, sulphamethoxazole, and sulphathiazole) were diazotized with nitrite and coupled with N-(1-naphthyl)ethylenediamine dihydrochloride in a sodium dodecyl sulphate (SDS) micellar medium. Separation of the sulphonamide azo dyes was performed on a C18 column with a 0.05 M SDS-2.4% pentanol mobile phase, which permitted the direct injection of the urine samples. The limits of detection were in the 0.1–0.3 μg/ml range.

Consumption in a varied or in a monotonous condition : women vs men

1995

International audience

13C and15N NMR study of substituted 1,2,4-triazines

1995

13C and 15N NMR spectra of eight substituted 1,2,4-triazines were measured and assigned. The assignments of the 13C NMR spectra were based on the substituent chemical shifts and nJ(C,H) coupling constants. 15N NMR chemical shifts generally showing well separated ranges were assigned by the proton coupled 15N NMR spectra. 15N NMR chemical shifts of N-4 in 3- and 5-methoxy or -thiomethyl-substituted 1,2,4-triazines were found to be related significantly (confidence level >99%) with the π-charge at N-4 calculated by a semi-empirical molecular orbital (AM1) procedure. For the 15N NMR chemical shifts of N-1 and N-2, no reliable correlations with the molecular electronic properties such as AM1 π-…

HCV replication in mononuclear cells stimulates anti-HCV-secreting B cells and reflects nonresponsiveness to interferon-α

1995

Recently, it was demonstrated in chronic hepatitis C that the release of IgG and IgM anti-HCV antibodies by mononuclear cells (PBMCs) correlated with inflammatory activity, HCV persistence in serum, and negative outcome from antiviral therapy. Thus, persistent antigenic stimulation of the antibody-secreting B cells has been suggested. In this study, PBMCs were derived from 13 patients with chronic hepatitis C. Nucleic acids were extracted by the guanidine-thiocyanate-method, and plus- and minus-stranded HCV-RNAs were determined using primers from the 5'-untranslated region of HCV. Simultaneously, unstimulated PBMCs were cultured for 8 days and anti-HCV antibodies were detected in the supern…

Cytosolic Ca2+Content and Membrane Fluidity of Platelets and Polymorphonuclear Leucocytes in Diabetes Mellitus

1995

Considering the role played by platelets and leucocytes in diabetic disease and keeping in mind the strong correlation between functional and metabolic aspects that characterizes this clinical condition, we evaluated, in two groups of diabetics, respectively the platelet and polymorphonuclear (PMN) cytosolic Ca2+ content (employing the fluorescent probe Fura 2-AM) and membrane fluidity (using the fluorescent probe TMA-DPH and considering the fluorescence polarization degree, inversely related to the membrane fluidity). From the obtained results, it is evident that the platelet cytosolic Ca2+ content does not distinguish normals from diabetics of type 1 and 2; the platelet membrane fluidity …

Photoelectrochemistry in corrosion studies: achievements and perspectives

1995

Programmable opticaldigital processor for rank order and morphological filtering

1995

A flexible hybrid opto-electronic processor for rank-order and morphological filtering is presented. The system is based on the shadow-casting convolver architecture, and the threshold decomposition concept. It provides the possibility of programming the input image and structuring element at video rate. The possibilities of the processor are experimentally demonstrated.

Regio- and diastereoselective condensation of resorcarenes with primary amines and formaldehyde

1995

Abstract Mannich reactions of resorcarenes 1 with chiral amines yield single diastereomeric tetrakis-(benzodihydro-1,3-oxazine) derivatives 2 in high yields (80–90%). Epimerisation of these products occurs in the presence of acid.

Software tools for using a personal computer as a timer device to assess human kinematic performance: a case study.

1995

Frequently, the assessment of the physical condition of a sportsman depends on the evaluation of different tests, based on biomechanical performance. The data acquisition in these tests is usually hand made, because its automatization is difficult. But when movements are constrained by means of their specific nature, simple tools can be used to achieve that data acquisition. In this paper, a simple and inexpensive system is described to make use of the timing capabilities of a personal computer (PC) to use it as a timer, with applications in biomechanics and sport training. The data acquisition method is based on a PC that, using a specific programming dealing with event timing, gets signal…

Antiinflammatory activity and effects on isolated smooth muscle of extracts from differentTeucrium species

1995

The present study analyses the antiinflammatory effects and the action on in vitro motility of methanol and dichloromethanol extracts and stems of four Teucrium species (T. flavum, T. cartaginenses, T. buxifolium and T. pumillum). The antiinflammatory activity was tested in the carrageenan-induced paw oedema in rats. T. flavum methanol (200 mg/kg, i.p.) and dichloromethanol (138 mg/kg, i.p.) extracts showed a significant anti-inflammatory effect through the 24 h experimental period and reduced the Emax induced by histamine and serotonin in vitro on guinea-pig ileum and rat uterus respectively. These extracts did not modify the contractile effects induced by acetylcholine on rat duodenum and…

false

1995

Supramolecular structures based on 4-(3,5-dioxo-1,2,4-triazolidin-4-yl) benzoic acid (U4A) units act as effective junction zones in functionalized polybutadienes, resulting in the formation of thermoplastic elastomers. The dynamics on a molecular scale of the phenyl rings have been probed by 2H-NMR. In the polymeric system, there are three spatially separated environments, which are reflected in the mobility of the polar units. Phenyl rings which are incorporated in the structures are either rigid or undergo 180° phenyl flips. The small fraction of free functional groups move isotropically and their mobility is coupled to the dynamics of the polybutadiene matrix. In two model compounds, whe…