showing 36 of ~574560 from 574555 documents

Déclaration et vérification des créances. Déclaration effectuée par un préposé au nom d'une personne morale en vertu d'une subdélégation de pouvoirs,…

1995

International audience; (Com. 14 févr. 1995, Sté Solovam Crédit et autres c/ Sté SELVMI et autres ; Com. 14 févr. 1995, Sté Le Crédit de l'Est et autres c/ Sté SELVMI et autres ; Com. 14 févr. 1995, Mme Poincheval c/ Sté Fina France et autres ; Com. 14 févr. 1995, Société Générale et autres c/ Sté SELVMI et autres)

CréancierPersonne morale[SHS.DROIT]Humanities and Social Sciences/Law[SHS.DROIT] Humanities and Social Sciences/LawREDRESSEMENT ET LIQUIDATION JUDICIAIRESPouvoirDéclaration des créances

Familial aggregation of tumors and detection of hereditary non-polyposis colorectal cancer in 3-year experience of 2 population-based colorectal-canc…

1995

The clinical data of 2 population-based registries, located in areas with different incidence rates of colorectal cancer, were used in order to assess the role of familial factors in the pathogenesis of these tumors. The occurrence of tumors in family members was investigated in 389 subjects with colorectal cancer registered in Modena (Northern Italy, an area characterized by a high incidence of colorectal malignancies) between 1984 and 1986; similar information was obtained in 213 patients with tumors of the large bowel registered in Ragusa (Sicily, Southern Italy, an area of similar magnitude and with low incidence rates for these tumors) in the 3-year period 1988 to 1990. In both series,…

MaleCancer Researchmedicine.medical_specialtyColorectal cancerPopulationRisk FactorsInternal medicineEpidemiologyPrevalenceMedicineHumansRegistriesRisk factoreducationAgedFamily Healtheducation.field_of_studybusiness.industryIncidence (epidemiology)IncidenceCancerFamily aggregationmedicine.diseaseColorectal Neoplasms Hereditary NonpolyposisLynch syndromeSurgerynot availableOncologyItalyEvaluation Studies as TopicCase-Control StudiesFemalebusinessColorectal NeoplasmsInternational journal of cancer

Neutrino-less Double Beta Decay and Physics Beyond the Standard Model

1995

A brief sketch is given of the present observational status and future prospects of the physics of neutrino mass, including a survey of the various theoretical schemes of neutrino mass generation. Emphasis is given to those which are motivated by present experimental hints from solar and atmospheric neutrinos, as well as from cosmological data related to the dark matter question. The conceptual importance of neutrino-less double beta decay as a distinctive signature of the Majorana character of neutrinos is stressed. Barring accidental cancellations this process gives the strongest laboratory constraint on neutrino mass.

High Energy Physics - PhenomenologyHigh Energy Physics - Phenomenology (hep-ph)Physics::Instrumentation and DetectorsAstrophysics::High Energy Astrophysical PhenomenaHigh Energy Physics::PhenomenologyFOS: Physical sciencesHigh Energy Physics::Experiment

Clause donnant aux arbitres le pouvoir de proroger le délai de l'arbitrage. Validité, Prorogation décidée après l'expiration du délai d'arbitrage con…

1995

International audience; (Paris, 12 nov. 1993, Rev. arb. 1993. 75, Soc. Alexandre Films, c/ Soc. Partners Production ; Paris, 9 févr. 1995, inédit, R. Marchand c/ Soc. Sogea Atlantique)

Arbitre[SHS.DROIT]Humanities and Social Sciences/Law[SHS.DROIT] Humanities and Social Sciences/LawArbitrage interneARBITRAGEAccord des partiesProrogation de délai

Shape analysis of the level-spacing distribution around the metal-insulator transition in the three-dimensional Anderson model

1995

We present a new method for the numerical treatment of second order phase transitions using the level spacing distribution function $P(s)$. We show that the quantities introduced originally for the shape analysis of eigenvectors can be properly applied for the description of the eigenvalues as well. The position of the metal--insulator transition (MIT) of the three dimensional Anderson model and the critical exponent are evaluated. The shape analysis of $P(s)$ obtained numerically shows that near the MIT $P(s)$ is clearly different from both the Brody distribution and from Izrailev's formula, and the best description is of the form $P(s)=c_1\,s\exp(-c_2\,s^{1+\beta})$, with $\beta\approx 0.…

PhysicsPhase transitionDistribution functionCondensed matter physicsCondensed Matter (cond-mat)FOS: Physical sciencesCondensed MatterLevel-spacing distributionMetal–insulator transitionCritical exponentAnderson impurity modelShape analysis (digital geometry)Physical Review B

Prognostic value of histopathologic parameters of esophageal squamous cell carcinoma.

1995

Background. The grading of squamous cell carcinoma (SCC) of the esophagus as proposed by the World Health Organization (WHO) has not yet proved to be prognostically significant. Therefore, the prognostic impact of various histologic parameters was investigated and compared with that of the WHO grading. Methods. Hematoxylin and eosin-stained tumor samples from 138 patients with SCC of the esophagus who underwent potentially curative resection (no residual tumor or distant metastases) were evaluated for the following histologic parameters: degree of keratinization, nuclear polymorphism, pattern of invasion, mitotic activity, and inflammatory response. The prognostic impact of these parameters…

AdultMaleCancer Researchmedicine.medical_specialtyPathologyEsophageal NeoplasmsH&E stainMitosisGastroenterologyInternal medicinemedicineHumansEsophagusSurvival analysisAgedCell NucleusUnivariate analysisProportional hazards modelbusiness.industryEsophageal diseaseCancerMiddle Agedmedicine.diseasePrognosisSurvival Analysismedicine.anatomical_structureOncologyMultivariate AnalysisCarcinoma Squamous CellKeratinsHistopathologyFemalebusinessCancer

Inkorporation von Membranproteinen in festkörperunterstützte planare Lipidfilme

1995

ChemistryGeneral MedicineAngewandte Chemie

Protecting Groups. VonP. J. Kocienski. Thieme, Stuttgart, 1994. 265 S., Broschur 60.00 DM. – ISBN 3-13-135601-4

1995

media_common.quotation_subjectStuttgartGeneral MedicineArtHumanitiesmedia_commonAngewandte Chemie

Cell-cell and cell-collagen interactions influence gelatinase production by human breast-carcinoma cell line 8701-BC

1995

We previously produced evidence that the human mammary-carcinoma cell line 8701-BC expresses several metalloproteinases (MMP-1, -2, -9, and -10) and their tissue inhibitors. In order to obtain a better understanding of the environmental control over gelatinolytic activities, we have tested the enzyme production of 8701-BC cells, at time intervals after plating on different collagen substrates, i.e., types I, III, IV, V and OF/LB, used as films in culture dishes. Proteinase activities, released in the conditioned culture media, were tested by zymography on SDS-PAGE, and by quantificative analyses, using 14C carboxy-methylated transferrin as substrate in a liquid incubation medium. Enzymatic …

Cancer ResearchConfluencyKunitz STI protease inhibitorBreast NeoplasmsCell CommunicationBiologyTrypsinCulture MediaMolecular WeightOncologyBiochemistryCell–cell interactionGelatinasesCell cultureEndopeptidasesTumor Cells CulturedmedicineHumansGelatinaseSerine Proteinase InhibitorsZymographyCollagenCell Divisionmedicine.drugInternational Journal of Cancer

Sentence arbitrale. Secret du délibéré, Opinion dissidente, Communication aux parties, Conséquence, Le contrôle de la décision d'incompétence des arb…

1995

International audience; (Paris, 7 juill. 1994, Rev. arb. 1995. 106, note S. Jarvin ; Uzinexportimport Romanian Co c/ Attock Cement C°)

Arbitrage international[SHS.DROIT]Humanities and Social Sciences/LawCommunication d'une opinion dissidente[SHS.DROIT] Humanities and Social Sciences/LawARBITRAGESentence arbitraleSecret du délibéré

Suspension des poursuites individuelles. Créancier hypothécaire d'un époux in bonis marié sous le régime de communauté légale, Liquidation judiciaire…

1995

International audience; (Cass. ass. plén. 23 déc. 1994, Leclerc ès qual. c/ Union de Crédit pour le Bâtiment et autres, D. 1995, Jur. p. 145, rapp. Chartier et note Derrida)

Créancier[SHS.DROIT]Humanities and Social Sciences/LawArrêt des poursuites individuelles[SHS.DROIT] Humanities and Social Sciences/LawREDRESSEMENT ET LIQUIDATION JUDICIAIRESCréancier du conjointBien commun

Sentence arbitrale. Voie de recours, Appel, Délai, Point de départ, Signification de la sentence revêtue de l'exequatur, Article 1486, al. 2 NCPC

1995

International audience; (Civ. 2e, 15 févr. 1995, Soc. Sorco, inédit)

Délai[SHS.DROIT]Humanities and Social Sciences/LawAppel civil[SHS.DROIT] Humanities and Social Sciences/LawARBITRAGESentence arbitraleVoie de recours

dc transport in dissipative disordered one-dimensional systems

1995

We present a numerical study of the dc transport properties of dissipative disordered chains which are described by linear ensembles of interconnected scatterers. The elastic-scattering amplitudes are derived from an Anderson Hamiltonian with diagonal (site) disorder. Inelastic scattering is accounted for by connecting the sites of the Anderson chain to separate external electron reservoirs. The calculated wave-vector-dependent transmission probabilities are discussed for chains with different lengths and for different degrees of dissipation. Using the Landauer-B\"uttiker approach we obtain the dc resistance of the considered samples. Our results demonstrate the rather intricate competition…

PhysicsDc resistancesymbols.namesakeAmplitudeCondensed matter physicsDiagonalsymbolsDissipative systemElectronDissipationInelastic scatteringHamiltonian (quantum mechanics)Condensed Matter::Disordered Systems and Neural NetworksPhysical Review B

Allyl sulfides and flavonoids : action on xenobiotic metabolizing enzymes and modulation of chemical carcinogenesis

1995

International audience

[SDV] Life Sciences [q-bio][SDV]Life Sciences [q-bio]RATCARCINOGENESEComputingMilieux_MISCELLANEOUS

Duchenne muscular dystrophy and idiopathic hyperCKemia segregating in a family

1995

A 7-month-old boy with gross motor delay and failure to thrive presented with rhabdomyolysis following an acute asthmatic episode. During hospitalization an electrocardiographic conversion to a Wolff-Parkinson-White type 1 (WPW) pattern took place. Duchenne muscular dystrophy (DMD) was suspected based on elevated creatine kinase (CK) serum levels, muscle biopsy, and family history. The diagnosis was confirmed by molecular analysis, which documented a deletion corresponding to cDNA probe 1-2a in the dystrophin gene, in the propositus and in an affected male cousin of his mother. "Idiopathic" hyperCKemia was found in the propositus, his father, and 5 of his relatives. We suggest that the unus…

Malemusculoskeletal diseasescongenital hereditary and neonatal diseases and abnormalitiesPediatricsmedicine.medical_specialtyDuchenne muscular dystrophyMolecular Sequence DataGene mutationPolymerase Chain ReactionMuscular DystrophiesGenomic ImprintingPrenatal DiagnosisInternal medicinemedicineHumansFamily historyCreatine KinaseGenetics (clinical)X-linked recessive inheritanceDNA PrimersGenes DominantMuscle biopsyBase Sequencebiologymedicine.diagnostic_testGenetic Carrier ScreeningInfantExonsmedicine.diseasePedigreeEndocrinologyMutationFailure to thrivebiology.proteinFemaleCreatine kinasemedicine.symptomDystrophinMetabolism Inborn ErrorsAmerican Journal of Medical Genetics

Algebraic approach to vibrational spectra of tetrahedral molecules. First order infrared intensity model.

1995

International audience; The algebraic approach we have proposed to describe the vibrational stretching modes of polyatomic molecules (Leroy and Michelot, J. Mol. Spectrosc. 151, 71–96 (1992); Can. J. Phys. 72, 274–289 (1994)) is applied to the silane molecule for up to seven quanta. We then suggest a form of the dipole operator adapted to the (n000) local states by combining the strength of group theory method with the necessity of a compact formulation.

Physics010304 chemical physics[ PHYS.QPHY ] Physics [physics]/Quantum Physics [quant-ph]InfraredOperator (physics)Polyatomic ionVibrational Spectra. Algebraic Approach. Intensity modelTetrahedral molecular geometry010402 general chemistry01 natural sciencesAtomic and Molecular Physics and Optics0104 chemical sciencesDipole[PHYS.QPHY]Physics [physics]/Quantum Physics [quant-ph]Quantum mechanics0103 physical sciencesMoleculePhysical and Theoretical ChemistryAlgebraic numberAtomic physicsSpectroscopyGroup theory[PHYS.QPHY] Physics [physics]/Quantum Physics [quant-ph]

Bounds on Neutrino Transition Magnetic Moments in Random Magnetic Fields

1995

We consider the conversions of active to sterile Majorana neutrinos $\nu_{a}$ and $\nu_{s}$, due to neutrino transition magnetic moments in the presence of random magnetic fields (r.m.f.) generated at the electroweak phase transition. From a simple Schr\"{o}dinger-type evolution equation, we derive a stringent constraint on the corresponding transition magnetic moments and display it as a function of the domain size and field geometry. For typical parameter choices one gets limits much stronger than usually derived from stellar energy loss considerations. These bounds are consistent with the hypothesis of seeding of galactic magnetic fields by primordial fields surviving past the re-combina…

PhysicsNuclear and High Energy PhysicsPhase transitionParticle physicsField (physics)Magnetic momentElectroweak interactionHigh Energy Physics::PhenomenologyFísicaFOS: Physical sciencesMagnetic fieldHigh Energy Physics - PhenomenologyMAJORANASupernovaHigh Energy Physics - Phenomenology (hep-ph)Neutrino

Dynamical left-right symmetry breaking.

1995

We study a left--right symmetric model which contains only elementary gauge boson and fermion fields and no scalars. The phenomenologically required symmetry breaking emerges dynamically leading to a composite Higgs sector with a renormalizable effective Lagrangian. We discuss the pattern of symmetry breaking and phenomenological consequences of this scenario. It is shown that a viable top quark mass can be achieved for the ratio of the VEVs of the bi--doublet $\tan\beta\equiv\kappa/\kappa'$ =~ 1.3--4. For a theoretically plausible choice of the parameters the right--handed scale can be as low as $\sim 20 TeV$; in this case one expects several intermediate and low--scale scalars in addition…

PhysicsNuclear and High Energy PhysicsParticle physicsGauge bosonSpontaneous symmetry breakingHigh Energy Physics::LatticeHigh Energy Physics::PhenomenologyFísicaFOS: Physical sciencesHiggs sectorStandard ModelHiggs fieldExplicit symmetry breakingHigh Energy Physics - PhenomenologyHigh Energy Physics - Phenomenology (hep-ph)Higgs bosonHigh Energy Physics::ExperimentSymmetry breakingPhysical review. D, Particles and fields

Metformin induces an agonist-specific increase in albumin production by primary cultured rat hepatocytes

1995

Abstract Metformin (MET) is known to increase several biological effects of insulin (INS), but there is no information concerning its direct effects on protein synthesis. We studied the action of MET on albumin production by primary cultures of freshly isolated rat hepatocytes, alone or in combination with various agonists: INS, IGF-1, EGF, thyroxin, and dexamethasone. While having no effect alone, MET in vitro potentiates the effects of INS, IGF-1, and EGF. When this increasing effect toward INS was studied over a broad concentration range, MET appeared to improve low-acting INS levels and to intensify the maximal INS effects. In contrast, MET did not change the production of albumin stimu…

MaleAgonistmedicine.medical_specialtyTime FactorsCell Survivalmedicine.drug_classBiologyBiochemistryIn vivoCell surface receptorAlbuminsInternal medicinemedicineAnimalsInsulinInsulin-Like Growth Factor IRats WistarCells CulturedPharmacologyEpidermal Growth FactorBody WeightAlbuminMetforminIn vitroRatsMetforminmedicine.anatomical_structureEndocrinologyLiverCell cultureHepatocytemedicine.drugBiochemical Pharmacology

A consistent study of the the low energy baryon spectrum and the nucleon-nucleon interaction within the chiral quark model

1995

By solving the Schr\"{o}dinger equation for the three-quark system in the hyperspherical harmonic approach, we have studied the low energy part of the nucleon and $\Delta$ spectra using a quark-quark interaction which reproduces the nucleon-nucleon phenomenology. The quark-quark hamiltonian considered includes, besides the usual one-gluon exchange, pion and sigma exchanges generated by the chiral symmetry breaking. The baryonic spectrum obtained is reasonable and the resulting wave function gives consistency to the ansatz used in the two baryon system.

PhysicsNuclear and High Energy PhysicsParticle physicsNuclear TheoryHigh Energy Physics::LatticeHigh Energy Physics::PhenomenologyNuclear TheoryQuark modelFOS: Physical sciencesFísicaNuclear Theory (nucl-th)Baryonsymbols.namesakePionsymbolsHigh Energy Physics::ExperimentNuclear ExperimentHamiltonian (quantum mechanics)Chiral symmetry breakingNucleonWave functionAnsatzPhysics Letters B

Supersymmetric quantization of gauge theories

1995

We develop a new operator quantization scheme for gauge theories in which the dynamics of the ghost sector is described by an N=2 supersymmetry. In this scheme no gauge condition is imposed on the gauge fields. The corresponding path integral is explicitly Lorentz invariant and, in contrast to the BRST-BFV path integral in the Lorentz gauge, it is free of the Gribov ambiguity, i.e., it is also valid in the non-perturbative domain. The formalism can therefore be used to study the non-perturbative properties of gauge theories in the infra-red region (gluon confinement).

High Energy Physics - TheoryHigh Energy Physics::TheoryHigh Energy Physics - Theory (hep-th)High Energy Physics::LatticeHigh Energy Physics::PhenomenologyFOS: Physical sciences

Modeling of continuous Ph-stat stirred tank reactor withLactococcus lactisssp.lactisbv.diacetylactisimmobilized in calcium alginate gel beads

1995

A dynamic diffusion-reaction-growth model is proposed for the study of lactic fermentation, the bioconversion of citric acid, and cell release in an immobilized cell reactor [pH-stat continuous stirred tank-reactor (CSTR)]. The model correctly simulates the onset of fermentation and colonization of the gel, followed by the steady state. External diffusion is nonlimiting and internal diffusion is limited by high cell densities at the periphery of the gel beads. Lactose-citrate cometabolism in the gel is related to the distribution of active included biomass within the gel and to gradients of substrates (lactose, citrate) and products (lactate, pH) in the beads. The utilization of lactose is …

ChromatographyCalcium alginatebiologyBioconversionLactococcus lactisContinuous stirred-tank reactorBioengineeringbiology.organism_classificationApplied Microbiology and Biotechnologychemistry.chemical_compoundBiochemistrychemistryFermentationLactoseCitric acidLactic acid fermentationBiotechnologyBiotechnology and Bioengineering

Study of peptides from hydrosoluble fraction of goat's cheese

1995

National audience

[SDV] Life Sciences [q-bio][SDV]Life Sciences [q-bio]ComputingMilieux_MISCELLANEOUS

E decays to ηππ in annihilation at rest

1995

Abstract We have observed the ηπ + π − and ηπ 0 π 0 decay modes of the E meson in p p annihilation at rest into π + π − π 0 π 0 η . The mass and width of the E meson are 1409 ± 3 and 86 ± 10 MeV. The production and decay branching ratio is B( p p → Eππ)B(E → ηππ) = (3.3 ± 1.0) × 10 −3 . With a spin-parity analysis we determine that J P = 0 − . The observation of the ηπ 0 π 0 decay mode establishes that E is isoscalar ( C = +1). We find that E decays to η ( ππ ) s (where ( ππ ) s is an S-wave dipion) and πa 0 (980)(→ πη ) with a relative branching ratio of (78 ± 16) %. Using the K K π production and decay branching ratio measured earlier we determine that B[E → K K π] B[E → ηππ] = 0.61 ± 0.1…

Nuclear physicsPhysicsNuclear and High Energy PhysicsAngular distributionAnnihilationMesonBranching fractionIsoscalarMass spectrumPhysics Letters B

Zur erweitrten Indikationsstellung der Herbert-Schrauben-Osteosynthese

1995

Since 1984 the typical headless double threaded Herbert/Whipple screw is known in managing scaphoid fractures and scaphoid non-unions. We resume technical, biomechanical and histological aspects to point out advantages and disadvantages of this osteosynthesis. Our case review of 39 patients illustrate the same good results as achieved in treating scaphoid injuries, when using the Herbert/Whipple screw of a larger diameter for expanded indications other than scaphoid fractures, such as humeral- or radial-head fractures, Jones fractures and others.

Bone screwsOrthodonticsCarpal bonesmedicine.anatomical_structureOsteosynthesisbusiness.industrymedicineSurgeryKnee injuriesbusinessCase reviewWrist injuryHerbert screwUnfallchirurgie

EFFECTS OF PHORBOL 12,13-DIACETATE AND ITS INFLUENCE ON SPASMOGENIC RESPONSES IN NORMAL AND SENSITIZED GUINEA-PIG TRACHEA

1995

Abstract We have studied the effects of phorbol 12,13-diacetate (PDA) and its influence on a variety of spasmogenic responses in trachea isolated in from normal and sensitized guinea-pigs. Tracheal preparations were denuded of epithelium, treated with indomethacin (2·8 μm), and cooled to 20°C. In these experimental conditions, tracheal strips contracted to PDA (0·1 nm-1 μm). Contractions to PDA (1 μm) were greater in sensitized tissues. In normal trachea, contractions to PDA (0·1 μm) were depressed by H-7, 1-(5-isoquinolinyl-sulphonyl)-2-methylpiperazine, (50 μm), amiloride (10 μm), verapamil (10 μm) and Ca2+-free exposure. Similar effects were obtained in sensitized trachea except that PDA…

Malemedicine.medical_specialtySerotoninContraction (grammar)Vasodilator AgentseducationGuinea PigsIndomethacinPharmaceutical ScienceIn Vitro TechniquesPiperazinesPotassium ChlorideGuinea pigAmiloridechemistry.chemical_compoundInternal medicine1-(5-Isoquinolinesulfonyl)-2-MethylpiperazinePhorbol EstersmedicineAnimalsDiureticsProtein Kinase CPharmacologyMuscle Smoothrespiratory systemIsoquinolinesAmilorideTracheaEndocrinologychemistryVerapamilPhorbolVerapamilCalciummedicine.symptomHistamineAcetylcholinemedicine.drugMuscle contractionHistamineMuscle Contraction

U-Pb data on zircons for the thermal peak of metamorphism in the Variscan Odenwald, Germany

1995

U-Pb data are presented for zircons from metamorphic rocks of the crystalline Odenwald that comprises part of the Mid-German Crystalline Rise. The Odenwald can be divided into four principal domains with different magmatic and metamorphic histories on the basis of published structural and petrological data and the presented ages. In the eastern (Boll-stein) Odenwald the metasedimentary rocks contain zircons derived from basement rocks that exceed 2.2 Ga in age. The intrusion of granitic magmas into these metasedimentary rocks took place before or close to the end of the thermal peak of metamorphism at 375 ± 5 Ma ago. Rapid uplift of the Bollstein Odenwald occurred at about 320 Ma bp, later …

IntrusionMetamorphic rockMagmatismGeochemistryPartial meltingGeneral Earth and Planetary SciencesMetamorphismSedimentologyStructural geologyMineral resource classificationGeologyGeologische Rundschau

Le nez électronique: nécessité ou gadget technologique ?

1995

National audience

[SDV] Life Sciences [q-bio][SDV]Life Sciences [q-bio]CONTROLE DE QUALITEINDUSTRIE AGROALIMENTAIREComputingMilieux_MISCELLANEOUS

Proton-dependent kinetics of citrate uptake in growing cells ofLactococcus lactissubsp.lactisbv.diacetylactis

1995

The kinetic analysis of citrate uptake in growing cells of Lactococcus lactis subsp. lactis biovar. diacetylactis identified a proton-dependent transport and suggested the divalent anionic species as the form of citrate transported across cell membranes. The reaction followed Michaelis-Menten kinetics for a two-substrate reaction. The limiting steps were the formation of the ternary complex and the rate of transport. Temperature modified the activity of the permease, increasing the uptake rate.

chemistry.chemical_classificationPermeaseKineticsLactococcus lactisCitrate transportBiologyMembrane transportbiology.organism_classificationStreptococcaceaeMicrobiologyDivalentchemistryBiochemistryGeneticsMolecular BiologyTernary complexFEMS Microbiology Letters

Prospective randomised trial of chemotherapy given before radiotherapy in childhood medulloblastoma. International society of paediatric oncology (SI…

1995

In a multicentre randomised clinical trial 364 children with biopsy proven medulloblastoma were randomly assigned to receive or not pre-radiotherapy chemotherapy. Children with total or subtotal removal of the tumour, no evidence of invasive brain stem involvement, and no evidence of metastatic disease either within or without the cranium were designated "low risk", those with gross residual tumour, evidence of invasive brain stem involvement or metastases in the central nervous system were designated "high risk". All children were prescribed 55 Gy to the tumour bearing area. "Low risk" children could be randomised to "standard" radiotherapy 35 Gy to the craniospinal axis or "reduced" dose …

MaleCancer ResearchVincristinemedicine.medical_specialtyPediatricsTime FactorsAdolescentmedicine.medical_treatmentProcarbazinelaw.inventionRandomized controlled trialRecurrenceRisk FactorslawAntineoplastic Combined Chemotherapy ProtocolsHumansMedicineProspective StudiesCerebellar NeoplasmsChildProspective cohort studyMedulloblastomabusiness.industryInfantRadiotherapy Dosagemedicine.diseaseCombined Modality TherapySurvival AnalysisSurgeryRadiation therapyClinical trialOncologyChild PreschoolPediatrics Perinatology and Child HealthFemalebusinessCraniospinalMedulloblastomamedicine.drugMedical and Pediatric Oncology

Methyl cellulose-based edible films and coatings I. Effect of plasticizer content on water and 1-octen-3-ol sorption and transport

1995

Edible films were prepared from methyl cellulose with various concentrations of poly(ethylene glycol) 400 (PEG400) used as a plasticizer. Water vapour and 1-octen-3-ol (an aroma compound) were selected as hydrophilic and hydrophobic volatile penetrants respectively. Their solubility and permeability through methyl cellulose-based edible films were studied using gas chromatography methods. Whatever penetrant was used, the flux increased with the PEG400 content. Transfer behaviour, i.e., the order of increased magnitude of the transfer rate, strongly depends on the nature of the volatile compound. However, water sorption only depends on the PEG400 content whereas the aroma compound sorption i…

Materials sciencePolymers and PlasticsPlasticizerfood and beveragesSorptionPermeationchemistry.chemical_compoundChemical engineeringchemistryMethyl celluloseOrganic chemistryAroma compoundGas chromatographySolubilityEthylene glycolCellulose

Metallatomsynthese, Eigenschaften und Struktur von μ 2 ‐(η 3 ,η 3 ‐Toluol)bis[(η 6 ‐toluol)eisen](Fe‐Fe)

1995

Metal Atom Synthesis, Properties, and Structure of μ2(η3,η3-Toluene)bis[(η6-toluene)iron](Fe-Fe) Metal atom cocondensation of iron atoms and toluene produces the mononuclear iron sandwich compound [(η6-toluene)(η4-toluene)Fe] 1. Complex 1 reacts with a palette of N-containing ligands such as primary, secondary, and tertiary amines as well as pyridine, pyrrolidine, and tmeda to form highly reactive instable intermediates. In the temperature range from -80 to -30°C, the proposed intermediates react with toluene to form the first homoleptic Fe/toluene complex μ2-(η3η3-toluene)-bis[(η6-toluene)iron](Fe-Fe) (3) regardless which N-containing ligand is used. Additionally, 3 is also formed when eth…

LigandInorganic chemistryTolueneDecompositionPyrrolidineInorganic ChemistryMetalchemistry.chemical_compoundchemistrySandwich compoundvisual_artPolymer chemistryPyridinevisual_art.visual_art_mediumHomolepticChemische Berichte

A comparative study of the sealing ability of two root canal obturation techniques

1995

A comparison was made of the ability of two root canal obturating techniques to prevent dye microleakage: gutta-percha lateral condensation and mechanically plasticized gutta-percha (JS Quick-fill). Twenty central incisors were prepared and obturated by each technique. After rendering the teeth transparent, linear dye penetration was found to be 0.48 and 0.52 mm, respectively. The difference between the two techniques was not significant. As for the distribution of the sealing cement (AH26) in the teeth obturated with JS Quickfill, the cement was located in the most peripheral zone of the obturation alongside the dentinal walls, whereas the gutta-percha was found in the central part of the …

Dental LeakageDye penetrationCementJS-quickfillRoot Canal ObturationMaterials sciencebusiness.industryRoot canalDentistryLateral condensationIncisorstomatognathic diseasesPeripheral zonemedicine.anatomical_structurestomatognathic systemEvaluation Studies as TopicRoot Canal ObturationmedicineHumansMaxillary central incisorGutta-PerchabusinessGeneral DentistryJournal of Endodontics

Preparation, crystal and molecular structure, and evaluation of plant growth regulating activity of guanidinoalkanephosphinates and phosphonates

1995

A series of previously unknown α-guanidinoalkanephosphonous, α- and β-guanidinoalkanephosphonic acids has been prepared in order to study their structures and biological activity. Aminoalkanephosphonous and phosphonic acids have been converted into their guanidino derivatives by means of S-methylisothiourea hydroiodide or cyanamide amidination. The crystal and molecular structures of three guanidino acids have been determined by single-crystal X-ray diffraction. The plant growth regulating activity of all synthesized guanidinoalkanephosphinates and phosphonates has been evaluated on Lepidium sativum. © 1995 John Wiley & Sons, Inc.

Lepidium sativumCrystalchemistry.chemical_compoundPlant growthchemistryStereochemistryMoleculeOrganic chemistryCyanamideBiological activityGeneral ChemistryHeteroatom Chemistry

Template-Directed Protein Folding into a Metastable State of Increased Activity

1995

The principal objective of this work was to distinguish between kinetic and thermodynamic reaction control in protein folding. The deleterious effects of a specific mutation on spontaneous refolding competence were analyzed for this purpose. A Bowman-Birk-type proteinase inhibitor of trypsin and chymotrypsin was selected as a double-headed model protein to facilitate the detection of functional irregularities by the use of functional assays. The parent protein spontaneously folds into a single, fully active and thermodynamically stable state in a redox buffer after reduction/denaturation. By contrast, the properties of a P'1Ser--Pro variant in the trypsin-reactive subdomain differ before an…

Protein FoldingProtein ConformationMolecular Sequence DataPopulationDNA RecombinantPhi value analysisBiochemistryDenaturation (biochemistry)Amino Acid SequenceeducationConformational isomerismTrypsin Inhibitor Bowman-Birk Soybeaneducation.field_of_studyChymotrypsinBase SequencebiologyChemistryGenetic VariationContact orderSolutionsKineticsCrystallographyModels Chemicalbiology.proteinThermodynamicsProtein foldingDownhill foldingEuropean Journal of Biochemistry

ortho-Substituent effects inN-arylacetamides. NMR and molecular mechanics investigation

1995

1H, 13C, 15N and 17O NMR spectra of N-phenylacetamide (acetanilide) and 21 ortho-substituted acetanilides were measured and assigned. The observed NMR parameters are related to the Hammett substituent parameters and conformational characteristics of the acetamido moiety estimated by molecular mechanics calculations. Significant relationships were found for the 13C NMR chemical shifts of C-5 (para to substituent) and the direct spin–spin coupling constant, 1J(C, H), of C-3 (ortho to substituent) with Hammett substituent parameters. For 15N NMR chemical shifts of the amido nitrogen, no general correlation with the Hammett substituent parameters was found. The interactions between functionalit…

Steric effectsChemistryStereochemistryChemical shiftOrganic ChemistrySubstituentCarbon-13 NMRRing (chemistry)Resonance (chemistry)Medicinal chemistrychemistry.chemical_compoundMoietyPhysical and Theoretical ChemistryAcetanilideJournal of Physical Organic Chemistry