showing 36 of ~574560 from 574555 documents
Stabilization of solutions of the filtration equation with absorption and non-linear flux
1995
This paper is primarily concerned with the large time behaviour of solutions of the initial boundary value problem $$\begin{gathered} u_t = \Delta \phi (u) - \varphi (x,u)in\Omega \times (0,\infty ) \hfill \\ - \frac{{\partial \phi (u)}}{{\partial \eta }} \in \beta (u)on\partial \Omega \times (0,\infty ) \hfill \\ u(x,0) = u_0 (x)in\Omega . \hfill \\ \end{gathered} $$ Problems of this sort arise in a number of areas of science; for instance, in models for gas or fluid flows in porous media and for the spread of certain biological populations.
Distinct Xp11.2 breakpoints in two renal cell carcinomas exhibiting X;autosome translocations
1995
Several human renal cell carcinomas with X;autosome translocations have been reported in recent years. The t(X; I)(p11.2;q21) appears to be a specific primary anomaly, suggesting that tumors with this translocation form a distinct subgroup of RCC. Here we report two new cases, one with a t(X;10)(p11.2;q23), the other with a t(X;1)(p11.2;p34). The common breakpoint in Xp11.2 suggests that they belong to the above-mentioned subset of RCC. Using FISH in conjunction with X-specific YAC clones, we demonstrate that the two new cases exhibited distinct breakpoints within Xp11.2. (C) 1995 Wiley-Liss, Inc.
4-4-20 anti-fluorescyl IgG Fab' recognition of membrane bound hapten: direct evidence for the role of protein and interfacial structure.
1995
The surface forces apparatus was used to identify the molecular forces that control the interactions of monoclonal 4-4-20 antifluorescyl IgG Fab' fragments with fluorescein-presenting supported planar bilayers. At long range, the electrostatic force between oriented Fab' and fluorescein monolayers was controlled by the composition of the protein exterior surrounding the antigen-combining site rather than by the overall protein charge. The measured positive electrostatic potential of the Fab' monolayer at pH > pI(Fab') was consistent with the structure of the exposed Fab' surface in which a ring of positive charge at the mouth of the antigen-combining site dominates the local electrostatic s…
Improvement of fibrinolysis and plasma lipoprotein levels induced by gemfibrozil in hypertriglyceridemia.
1995
A randomized double-blind study was carried out with gemfibrozil (600 mg b.i.d.) vs placebo in 20 patients (twelve males and eight females, age 52 +/- 3 years, BMI 24.2 +/- 0.4) suffering from primary hypertriglyceridemia (Fredrickson's type IV). Each group was treated for a 12 week period with gemfibrozil (n = 10) or placebo (n = 10) patients) in a double-blind fashion. Total cholesterol, HDL-cholesterol (HDL-C) and its subfractions (HDL2-C and HDL3-C), blood glucose, Apolipoproteins A1 and B, fibrinogen, plasminogen, factor VII, t-PA:Ag and PAI activity pre- and post-venous occlusion (VO) were determined. In the gemfibrozil-treated group a significant decrease of total cholesterol and tri…
B* production in Z decays
1995
The decay B*→Bγ has been observed with the DELPHI detector at LEP, where the B* meson is produced in Z boson decays. The combination of inclusively reconstructed B mesons with well-measured converted photons yields a measurement of the flavour-averaged B*-B mass difference of 45.5±0.3 (stat.) ±0.8 (syst.) MeV/c2. 95% confidence level upper limits at 6 MeV/c2 are placed on both the isospin (i.e. B+-B0) and the Bs-Bud splitting of the mass difference. The production ratio of B* to B mesons in Z decays is measured to be 0.72±0.03 (stat.) ±0.06 (syst.). Limits on the production cross-section of other hypothetical excited B hadron states decaying radiatively are established. The differential B* …
Gradual freezing of orientational degrees of freedom in cubicAr1−x(N2)xmixtures
1995
The mixed crystal ${\mathrm{Ar}}_{1\mathrm{\ensuremath{-}}\mathit{x}}$(${\mathrm{N}}_{2}$${)}_{\mathit{x}}$ is studied by Monte Carlo (MC) methods for x=0.33, 0.67, and 1.0 over a wide range of temperatures. For x=1 we find first-order transition from ordered cubic to disordered cubic, while for x=0.33 and x=0.67 we find broad nonuniform distribution functions of the local quadrupole Edwards-Anderson order parameter at low temperature. The short-range order of the quadrupolar mass distribution of the ${\mathrm{N}}_{2}$ molecules in the mixed systems is different from that observed in the pure ${\mathrm{N}}_{2}$ crystal, although the fcc symmetry has been chosen for the translational degrees…
Response to methimazole in Graves' disease
1995
Summary OBJECTIVE A variety of regimens continue to be used In the treatment of Graves' disease with antithyrold drugs. We have lnvestigated the factors which determine the initial response to methimazole (time until euthyroidism Is achieved) In Graves' disease. PATIENTS Five hundred and nine patients with Graves' disease in different European countries with normal and subnormal iodine supply. Patients were randomized to treatment with either 10 or 40mg of methimazole per day for one year, with levothyroxine supplementation as required to maintain euthyroidism. Investigations were carried out before treatment and at 3 and 6 weeks and 3, 6, 9 and 12 months. MEASUREMENTS Response was assessed…
Multiscaling Properties of Large-Scale Structure in the Universe
1995
The large-scale distribution of galaxies and galaxy clusters in the universe can be described in the mathematical language of multifractal sets. A particularly significant aspect of this description is that it furnishes a natural explanation for the observed differences in clustering properties of objects of different density in terms of multiscaling, the generic consequence of the application of a local density threshold to a multifractal set. The multiscaling hypothesis suggests ways of improving upon the traditional statistical measures of clustering pattern (correlation functions) and exploring further the connection between clustering pattern and dynamics.
Comparative studies on check-bite and central-bearing-point method for the remounting of complete dentures
1995
Thirty-six complete dentures were remounted both with check-bite as well as central-bearing-point (CBP) registration. The mandibular or denture position was registered in the condylar area three times with each method. Two independent operators carried out the registrations. One half of patients had their occlusion equilibrated according to the check-bite registration, the other half in the central-bearing-point position. After individual determination of the hinge axis the upper dentures were mounted by a face-bow transfer into a Dentatus articulator. A total of six registrations was performed and repeatedly compared in the condylar area in three dimensions using a computer supported measu…
Axillary shoot proliferation in cultures of explants from mature Juniperus oxycedrus trees.
1995
We developed procedures for the micropropagation of Juniperus oxycedrus L. using shoot apices or nodal segments from mature plants. Of the media and explants examined, best culture establishment was obtained with shoot apices cultured on modified Schenk and Hildebrandt medium (SH medium) without growth regulators; however, shoot multiplication was only achieved when shoot apices isolated from shoots grown on SH medium without growth regulators were subcultured on SH medium containing 0.5 micro M benzyladenine. None of the auxins and methods tested for root induction provided satisfactory results.
Synthesis and spectroscopic characterizations of both 1-ethyl-4,8-dihydro-10-methoxy-3-methyl-8-r1-6-r2-dipyrazolo[3,4-b:4′,3′-f]-[1,5]diazocin-5(1H)…
1995
The non-selective methylation of compounds 3a-d using ethereal diazomethane, allowed the synthesis of isomers 4 and 5 which were useful intermediates for the preparation, by a simple approach, of the title compounds 7 and 9. A complete assignment of the chemical shifts to the carbon atoms of the compounds 7 and 9 was performed by different nmr experiments, such as DEPT and XHDEPT for onebond CH correlations and COLOC experiments for long-range C-H correlations.
The eighth component of human complement: molecular basis of C8A (C81) polymorphism.
1995
Using an exon-specific polymerase chain reaction (PCR) followed by direct DNA sequence analysis we have analyzed the polymorphism of the alpha-chain of the eighth component of human complement (C8) at the DNA level. We found that two common alleles, C8A*A and C8A*B, are characterized by the substitution of a single amino acid (Gln to Lys), which is caused by a point mutation of a single nucleotide (C to A) in exon 3 at position 187 of the mature C8 alpha cDNA sequence. Based on this mutation, an allele-specific PCR was designed detecting the two alleles of C8A. We applied this method to type the C8A polymorphism using DNA samples from a Chinese Han population. The comparison with the data o…
MEASUREMENT OF ALPHA(S) FROM SCALING VIOLATIONS IN FRAGMENTATION FUNCTIONS IN E(+)E(-) ANNIHILATION
1995
A study of scaling violations in fragmentation functions performed by the ALEPH collaboration at LEP is presented. Data samples enriched in uds, c, b and gluon jets, respectively, together with measurements of the longitudinal and transverse inclusive cross sections are used to extract the fragmentation function for the gluon and for each flavour. The measurements are compared to data from experiments at energies between 22 GeV and 91 GeV and scaling violations consistent with QCD predictions are observed. From this, a measurement of the strong coupling constant alpha(s) (M(z)) = 0.126 +/- 0.009 is obtained.
The (2'-5')Oligoadenylate Synthetase is Present in the Lowest Multicellular Organisms, the Marine Sponges. Demonstration of the Existence and Identif…
1995
We have proved the presence of (2'-5')oligoadenylates [(2'-5')An] and oligoadenylate synthetase [(2'-5')An synthetase] in the marine sponge Geodia cydonium. (2'-5')An isolated from sponge crude extract competed with authentic (2'-5')An for binding to polyclonal antiserum against (2'-5')An. HPLC analysis revealed the presence of nucleotides eluting with molecular markers for (2'-5')A oligomers. The biological activity of sponge (2'-5')An was demonstrated by inhibiting the protein biosynthesis in rabbit reticulocyte lysate. The activity of the (2'-5')An synthetase, present in crude sponge extract, was found to be high compared to that in mammalian interferon-treated cell extract. The (2'-5')A…
Phase separation of symmetrical polymer mixtures in thin-film geometry
1995
Monte Carlo simulations of the bond fluctuation model of symmetrical polymer blends confined between two “neutral” repulsive walls are presented for chain lengthNA=NB=32 and a wide range of film thicknessD (fromD=8 toD=48 in units of the lattice spacing). The critical temperaturesTc(D) of unmixing are located by finite-size scaling methods, and it is shown that\(T_c (\infty ) - T_c (D) \propto D^{ - {1 \mathord{\left/ {\vphantom {1 {v_3 }}} \right. \kern-\nulldelimiterspace} {v_3 }}} \), wherev3≈0.63 is the correlation length exponent of the three-dimensional Ising model universality class. Contrary to this result, it is argued that the critical behavior of the films is ruled by two-dimensi…
Mate sampling behaviour of black grouse females (Tetrao tetrix)
1995
We studied female mate sampling behaviour in lekking black grouse (Tetrao tetrix). Females mainly visited males occupying territories in the centre of the lek with relatively large territories. They were also more likely to visit males that had high attendance. The same factors were also correlated with male mating success. A multiple regression model including these factors explained more of the variance in female visits per male (53%) than in mating success (33%). The pattern of female sampling conformed with a pool comparison (best-of-n) tactic. Such a tactic is expected if the costs of sampling are low. Females of high body mass visited more males than lighter females, however, which in…
[MoO2(SCPh2CO2)2]2− and [MoO(SCPh2CO2)2]− anion complexes. A theoretical structure characterization
1995
Abstract Geometry optimization of [MoO 2 (SCH 2 CO 2 ) 2 ] 2− and [MoO(SCH 2 CO 2 ) 2 ] − systems as models of [MoO 2 (SCPh 2 CO 2 ) 2 ] 2− and [MoO(SCPh 2 CO 2 ) 2 ] − anion complexes have been carried out at STO-3G, 3-21G, LANL1MB and LANL2DZ basis set levels. A comparison of the theoretical results and X-ray experimental data has been performed. STO-3G minimal basis set produces the best geometrical agreement, in particular the distances and orientations of the different ligands linked to molybdenum transition metal. A large structural overlap with STO-3G optimized geometry and X-ray data has been found for the [MoO 2 (SCPh 2 CO 2 ) 2 ] 2− and [MoO(SCPh 2 CO 2 ) 2 ] − anion complexes.
Clusterin gene expression in apoptotic MDCK cells is dependent on the apoptosis-inducing stimulus
1995
Abstract Clusterin (Apolipoprotein J, complement lysis inhibitor) is a widely expressed multifunctional glycoprotein. The expression of clusterin mRNA has been reported to be elevated in a broad spectrum of apoptotic or degenerative tissues. More recently, it was shown that within these tissues clusterin is expressed in the surviving rather than in the dying cells, and that clusterin gene expression is actually down-regulated in the apoptotic cells. We have studied the expression of the clusterin gene in apoptotic MDCK cells. Cell death was initiated by three different stimuli: application of the steroid hormone antagonist RU 486, activation of protein kinase C by the application of the pho…
And after all, if say was right ? L'offre crée-t-elle sa propre demande ? Keynésiannisme contre "klacissisme"
1995
In a real exchange economy it's quite easy to admit the existence of SAY's law. However, currency has without doubt changed. Is it necessary to reject SAY's law? More than J.M.KEYNES himself, if we believe some of his sucessors it's absolutely certain. Yet, when we study closely modern currency (bank currency) we realize that the economic agentscannot hold it outside the banking system: when they are not consumers on the goods market they are "consumers" on the stock market. As a consequence SA Y's law is confirmed.
Introduction of unsaturated segments in the bridge of metacyclophanes
1995
Abstract The cyclophanes 2a,b, which contain a triple bond in the meta-bridge, were transformed to the allenes 3a,b by the action of bases or acids. A further isomerization yielded the dienes 4a,b with ( E,Z )- or ( Z,Z )-configuration.
Nested PCR method for rapid and sensitive detection of Vibrio vulnificus in fish, sediments, and water
1995
A nested PCR for the detection of Vibrio vulnificus in fish farms was developed as an alternative to cultural methods by using universal primers flanking the V. vulnificus-specific sequences directed against 23S rRNA genes. This specific assay detected 10 fg of DNA or 12 to 120 cells in artificially inoculated samples without enrichment and within 24 h.
Models, predictions, and experimental measurements of far-infrared NH3-laser dynamics and comparisons with the Lorenz-Haken model
1995
Dynamics of the intensity and optical field amplitude of a coherently pumped far-infrared NH3-laser are measured and characterized. The experimental findings in certain parameter ranges closely follow the dynamics of the Lorenz model and its generalization for laser systems. Similarities and some specific differences are found in geometrical or statistical characterizations of the attractors. The experimental results are also consistent with the results of a model of optically pumped three-level lasers which takes into account the presence of a multiplicity of velocity groups as well as three-level coherence effects. For a certain region in parameter space, this far more complex model with …
Autoreactivity to mouse C1q in a murine model of SLE.
1995
A large proportion of systemic lupus erythematosus (SLE) patients develop glomerulonephritis, coincident with the appearance of autoantibodies to C1q, the Fc-recognizing collagen-like subcomponent of the first component of complement, C1. The MRL/lpr/lpr mouse is an established model for SLE, developing both antinuclear and anti-type II collagen autoantibodies, and rheumatoid factors(s), exhibiting reduced complement levels and later on developing glomerulonephritis and often arthritis. We report here an age-dependent decrease in serum C1q levels coincident with the development of IgG2b autoantibodies reactive with mouse C1q in MRL/lpr/lpr mice. Unlike IgG2b, although high levels of IgM, Ig…
Jaynes-Cummings model with atomic position distribution
1995
The position as well as the width of the atomic wave packet passing through an optical cavity may affect the matter-field interaction. As a result, the internal dynamics of a two-level atom, such as the Rabi oscillations or the collapse and revival phenomenon, may be strongly modified with respect to the standard Jaynes-Cummings model. In particular, for a sufficiently large spread of the atomic position, the atomic population inversion displays the characteristic ringing behavior of the Bessel function ${\mathit{J}}_{0}$ differently from the usual full Rabi oscillation.
Effect of low levels of dietary fish oil on fatty acid desaturation and tissue fatty acids in obese and lean rats
1995
The effect of very low levels of dietary long-chain n-3 fatty acids on delta 6 desaturation of linoleic acid (18:2n-6) and alpha-linolenic acid (18:3n-3), and on delta 5 desaturation of dihomo-gamma-linolenic acid (20:3n-6), in liver microsomes and its influence on tissue fatty acids were examined in obese and lean Zucker rats and in Wistar rats. Animals fed for 12 wk a balanced diet containing ca. 200 mg of long-chain polyunsaturated n-3 fatty acids per 100 g of diet were compared to those fed the same amount of alpha-linolenic acid. Low amounts of long-chain n-3 fatty acids greatly inhibited delta 6 desaturation of 18:2n-6 and delta 5 desaturation of 20:3n-6, while delta 6 desaturation of…
Achalasia and carcinoma of the esophagus
1995
Different figures regarding the relationship between achalasia and carcinoma of the esophagus can be found in the literature. Often achalasia is considered as a risk factor. The author analyzing the data collected from the Shanghai Chest Hospital (S.C.H.) and the Pathophysiology Department of the University of Palermo, both referring centers for esophageal diseases conclude that carcinoma of the esophagus in achalasic patients is just a coincidence and no relationship can be found between the two diseases.
Organization of the major and minor capsid proteins in human papillomavirus type 33 virus-like particles.
1995
The organization of the major (L1) and minor (L2) proteins in the human papillomavirus capsid is still largely unknown. In this study we analysed the disulphide bonding between L1 proteins and the association of L2 proteins with capsomers using virus-like particles obtained in insect cells by co-expression of the L1 and L2 genes of human papillomavirus type 33. About 50% of the L1 protein molecules in these particles (1.29 g/cm3) formed disulphide-bonded trimers. Reduction of the intermolecular disulphide bonds by dithiothreitol (DTT) treatment caused disassembly of virus-like particles into capsomers. This indicates that disulphide bonds between capsomers at the threefold symmetry position…
Level lifetimes in neutron-rich Ru isotopes
1995
The neutron-rich Ru isotopes are situated between the strongly deformed Sr-Zr region with axial deformation of f l _ 0.40 [1] and the spherical Cd-Sn region. Evidence for triaxiality of even-even Ru isotopes has been presented in [2-5], and lifetimes of some of their 2 + states have been measured in fission studies [6-9]. It seems, however, that in these experiments the nearly identical energies of the 2 + ---* 0 + transitions in l~ and 11~ could not be separated. Therefore, high-resolution measurements are required in order to perceive the evolution of deformation with increasing neutron number. So far only few measurements by the delayed-coincidence method [10] have been performed on chem…
Ecological genetics of a cyclical parthenogen in temporary habitats
1995
Populations of the rotifer Brachionus plicatilis inhabiting three temporary ponds in Torreblanca Marsh (Castellon, Spain) were regularly screened for allozyme variation, sexual reproduction levels and population densities during an annual cycle. Relevant ecological parameters in the ponds were also recorded. The electrophoretic survey of the three ponds (Poza Sur, Poza Norte and Canal Central) revealed a high level of overall genetic polymorphism in four marker loci, but only 13 multilocus genotypes were found. We classified clones into three clonal groups (SS, SM, L) characterized by unique arrays of alleles in the four marker loci, and significant differences in body shape and size. Clona…
The processing of water vapor and aerosols by atmospheric clouds, a global estimate
1995
Recent data published in literature on global cloudiness and precipitation as well as data on updrafts in clouds and their liquid water contents allow us to estimate the global turnover of water vapor and liquid water in the atmosphere. From these turnover rates the global average capacity of clouds to uptake, store and release atmospheric aerosol mass and the rate of wet deposition on the ground was estimated. The results of such an estimate suggest that clouds contribute significantly to the processing of aerosol material in the atmosphere as they constitute an important temporary storage location for it. Although the contribution of aerosol mass resulting from a single evaporation of the…
Ion Pairing in the Analysis of Voltammetric Data at the ITIES: RbTPB and RbTPBCl in 1,2-dichloroethane
1995
The association of rubidium-tetraphenylborate (RbTPB) and rubidium-tetrakis(-chlorophenyl)borate (RbTPBCl) ion pairs in the organic solvent 1,2-dichloroethane (DCE) have been obtained from condutivity and voltammetric data. Conductivity measurements given K RbTPBCl =43 100 M -1 and yield a lower bound for K RbTPB (K RbTPB > 70000 M -1 ). The latter association constant is at variance with the previously accepted value. A method for analysing voltammetric data which allows for the determination of the association constants is presented. The positive polarization limit where the transfer of Rb + takes place is shifted by ca. 200 mV when changing the anion of the organic base electrolyte from …
Search for the decay KL → 3γ
1995
Abstract Data from the NA31 experiment at the CERN SPS have been used for the first search for the decay mode KL → 3γ. Seven events have been found with an estimated background of 6.7 ± 1.5 events. The corresponding upper limit for the branching ratio is Γ(K L → 3γ) Γ(K L → all ) = 2.4 × 10 −7 at the 90% confidence level, assuming a phase-space decay distribution.
Urinary diversion in bladder exstrophy and incontinent epispadias: 25 years of experience.
1995
To determine the optimal surgical approach in achieving complete urinary continence with preservation of the upper urinary tract in the exstrophy-epispadias complex we reviewed the records of patients treated at our institution.From 1968 to July 1994, 115 patients with bladder exstrophy/incontinent epispadias were treated of whom followup was available for 104 and 2 died of causes unrelated to urinary diversion. Mean followup is 16.7 years. In 43 of the 102 patients surgery was primarily performed at our institution (urinary diversion in 39, a modified Young-Dees procedure in 1 and sling plasty in 3). In another 59 patients urinary diversion was done secondarily after therapy elsewhere (bla…
Sonographische Verlaufskontrolle von experimentellen Muskelverletzungen
1995
Experimental muscle lesions were produced in 28 rabbits by stab incision, thus creating a lesion of known extent and site. The changes in the course of healing were followed up and documented at short intervals for a period of two months via sonography. The changes take place in regular course and can be explained by fine tissue changes, taking into consideration the fundamentals of theoretical ultrasound physics. Sonography renders both valuable assistance in diagnosing muscular lesions and in following up the healing process--the latter, however, with some reservations due to the clinical terminology defining the extent of muscular lesions.
The addition of interleukin-2 to cyclophosphamide therapy can facilitate tumor growth of B16 melanoma.
1995
The role of interleukin-2 (IL-2) on tumor growth of B16F10 melanoma cells was assessed in two sets of mice with different immune status: normal (immunocompetent) mice and immunodeficient mice. The two sets of animals were treated with cyclophosphamide (CY) or IL-2 alone or with a combined therapy of CY+IL-2. On days 6 and 10 after tumor cell injection, we evaluated the incidence of hepatic B16 melanoma metastases and the percentage of hepatic volume occupied by metastatic tissue. We observed that the CY alone (300 mg/kg, days 3 and 8 post-tumoral inoculation) significantly reduced tumor growth in all treated mice; however, CY proved more effective in normal recipients than in immunodeficien…
Carbohydrates as Chemical Constituents of Biowaste Composts and their Humic and Fulvic Acids
1995
The decomposition of organic matter of source-separated biowaste during composting was followed during 18 months. Compost samples were fractionated into three parts: (i) hot water soluble extract (HWE) (ii) bitumen fraction and (iii) humic substances (humic acids (HA) and fulvic acids (FA)). Original compost samples and the HA and FA fractions were hydrolyzed with sulfuric acid for hexoses and pentoses. Quantitative spectrophotometric and qualitative GC/MS analyses of monosaccharides as trimethylsilyl ethers of the corresponding alditols were carried out.During composting, the amount of HA in the organic matter of the compost increased, the amounts of HWE and bitumen decreased and the amoun…