NMDA-GABA interactions in an animal model of behaviour: a gating mechanism from motivation toward psychotic-like symptoms

1994

We studied the effects of desipramine, alprazolam, muscimol and dizocilpine (MK-801) (alone or associated with desipramine) in the forced swimming test in rats after long-lasting termination of chronic exposure to vehicle and pentylenetetrazol. Sensitisation with pentylenetetrazol was ineffective in changing immobility time in the forced swimming test compared to vehicle treatment; pentylenetetrazol enhanced the anti-immobility effect of desipramine, abolished the anti-immobility effect of alprazolam and did not affect the anti-immobility effect of muscimol. MK-801 at the dose that did not modify immobility time in vehicle-treated rats and in pentylenetetrazol-treated animals strongly poten…

Response by macrozoobenthos biomass to water level regulation in some Finnish lake littoral zones

1994

The relationship of the macrozoobenthos biomass in the littoral area to the yearly fluctuation in water level and the characteristics of the area or lake are studied using data collected from sheltered bays in regulated and natural waters. Most of the lakes were clear and oligotrophic. The benthos biomass at all depths in the littoral decreased with increased water level fluctuation, provided that the transparency of the water was uniform.

Synthesis of polyvinyl acetate-graft-poly-2-oxazolines

1994

Poly(vinyl acetate-co-vinyl chloroformate) (1) was synthesized via phosgenation of poly(vinyl acetate-co-vinyl alcohol). It was shown that (1) is capable of initiating the polymerization of 2-phenyl-2-oxazoline and 2-methyl-2-oxazoline, when the counter ion is exchanged using potassium iodide. Polyvinyl acetate-graft-poly-2-phenyl-2-oxazoline and polyvinyl acetate-graft-poly-2-methyl-2-oxazoline are obtained in the grafting reaction.

Steroid hormone receptors in the female urogenital tract

1994

The increasing clinical use of estrogens in the treatment of stress-incontinent women caused us to examine receptor patterns in the female bladder and urethral tissue, and to characterize possible receptors by means of Scatchard plot analysis, competition experiments and density gradient centrifugation.

Mechanism of anionic polymerization of (meth)acrylates in the presence of aluminium alkyls, 1. 13C NMR studies of model compounds in toluene

1994

The bimetallic ate complex [(CH 3 ) 2 C=C(OEt)(O - AlR 3 )]Li + is regarded to be the model of the active centre of the polymerization of methyl methacrylate in the presence of aluminium alkyls. This complex is detectable by 13 C NMR up to 273 K. At ambient temperature irreversible decomposition takes place. Apart from the formation of the ate complex, excess aluminium chloride coordinates to the ester carbonyl groups of both the monomer and the polymer chain

Surface effects on spinodal decomposition in binary mixtures and the interplay with wetting phenomena.

1994

The phase separation of binary mixtures in a semi-infinite geometry is investigated both by a phenomenological theory and by numerical calculations using a discrete equivalent of the descriptive equations. In the framework of ``model B'' (which describes solid binary mixtures), attention is paid to a proper treatment of the boundary conditions at the free surfaces. We confine ourselves to short-range surface forces and consider parameter values that correspond to both nonwet and wet surfaces in thermal equilibrium. During the initial stages of spinodal decomposition, after a quench from considering an initial condition that corresponds to a completely random concentration distribution, one …

Comparative study of a whole-cell pertussis vaccine and a recombinant acellular pertussis vaccine.

1994

The safety and immunogenicity of an acellular pertussis vaccine containing the genetically detoxified pertussis toxin PT-9K/129C, filamentous hemagglutinin, and pertactin, together with diphtheria and tetanus toxoids, were compared with those of a whole-cell pertussis component-diphtheria-tetanus vaccine. Four hundred eighty infants were enrolled into this prospective, multicenter, double-blind study. Each infant was randomly given three doses of one of the two vaccines at 2, 4, and 6 months of age. Both local and systemic adverse reactions, reported within 48 hours and 7 days of each injection, were less frequent after the acellular vaccine than after the whole-cell vaccine. The enzyme-lin…

Besonderheiten der Behandlung des akuten Schmerzes im Kindesalter

1994

Die perioperative Analgesie kann mit peripher und zentral wirkenden Analgetika und mit Hilfe von Regionalanasthesieverfahren durchgefuhrt werden. Wenn mit peripherwirkenden Analgetika eine ausreichende Analgesie nicht erzielt werden kann, mussen zentralwirkende Analgetika oder Regionalanasthesieverfahren angewandt werden. Die Nebenwirkungen der zentralwirkenden Analgetika mussen bedacht werden. Zentralwirkende Analgetika durfen nur verabreicht werden, wenn eine intensive Uberwachung des Kindes gewahrleistet ist. Eine Alternative zur Gabe von Opioiden sind Regionalanasthesieverfahren. Die Vor- und Nachteile der unterschiedlichen Regionalanasthesietechniken mussen berucksichtigt werden. Vorzu…

Expression of homeobox-containing genes in the sea urchin (Parancentrotus lividus) embryo

1994

Two homeobox-containing genes that belong to different homeodomain classes have been isolated from a sea urchin geonomic library. One, PlHbox11, is the sea urchin homologue of the human and mouse Hox B3 gene, the other, PlHbox12, shows about 55% identity with paired class genes. Expression profile analysis of the two sea urchin Hbox genes suggests that they play different roles during embryogenesis. In fact, PlHbox11 transcripts are rare and are detected only in the pluteus larva and in the Aristotle's lantern and intestine of the adult. The PlHbox12 gene is, on the contrary, transiently expressed in the very early embryo already at the four cell stage; it accumulates at the 64 cell stage a…

The macrophage-activating tetrapeptide tuftsin induces nitric oxide synthesis and stimulates murine macrophages to kill Leishmania parasites in vitro.

1994

The macrophage-activating tetrapeptide tuftsin was able to activate, in a dose-dependent manner, murine macrophages to express nitric oxide (NO) synthase and to produce NO. Tuftsin required lipopolysaccharides for the optimal induction of NO production and synergized with gamma interferon in the induction of NO synthesis. Tuftsin-dependent NO production was sensitive to inhibition by dexamethasone and the NO synthase specific inhibitor LGN-monomethylarginine (L-NMMA). Murine peritoneal macrophages activated by tuftsin were able to kill the amastigotes of the intracellular protozoan parasite Leishmania major in vitro.

Bringing pupils' learning closer to a scientific construction of knowledge: A permanent feature in innovations in science teaching

1994

In this article we intend to show that the idea of linking science learning to the way of doing science constitutes a permanent feature, although not always explicit, in innovations in science teaching. A thread which, in our opinion, has shown itself to be fruitful, even through its wrong avenues, and that is being reinforced nowadays by the emerging constructivist paradigm and by the implications of the contemporary philosophy of science in science education.

Beta decay of very neutron-rich110Mo studied at the new IGISOL facility

1994

The decay of the new activity110Mo (t1/2=0.30(4).s) has been observed at the new IGISOL separator. Multiscaled singles,β-γ-t and γ-y-t coincidences were recorded. The decay scheme suggests Iπ=2+ for the ground state of the daughter nucleus110Tc. Three 1+ levels are fed with logft values below 5, indicating no drastic change among Mo and Ru decays at the middle of the neutron shell. This experiment confirms the expectation that the new IGISOL facility will allow the identification of one or two new more neutron-rich isotopes per element in this region.

A microcalorimetric comparison of the effect ofn-alkane preadsorption on the adsorption of argon and nitrogen on Silicalite-I

1994

Then-alkanes of different lengths were preadsorbed to selectively block part of the micropores of a MFI-type zeolite, Silicalite-I. The porosity available to argon and nitrogen was then studied by quasi-equilibrium adsorption microcalorimetry and volumetry at 77K and compared to what was found for the bare zeolite. Indeed, although partial adsorption ofn-alkanes does not alter the value of the differential enthalpies of adsorption for both argon and nitrogen, then-butane preadsorption diminishes the adsorption capacity by inducing inaccessible volumes in the micropore network. Moreover, the microcalorimetric experiments clearly show thatn-butane is not evenly distributed in the zeolite chan…

Mathematikdidaktik als Textwissenschaft

1994

Es wird zunachst ein Uberblick uber die Verwendung von Texten in der empirischen mathematikdidaktischen Forschung gegeben. Der hierbei zugrunde gelegte alltagsweltliche Textbegriff wird sodann im Rahmen einer Theorie des Textes (RICOEUR) reflektiert und erweitert. Daran anschliesend wird die These von der Textformigkeit jeder mathematikdidaktisch relevanten Untersuchungswirklichkeit dargestellt und begrundet. Diese Perspektive fuhrt zu einer Diskussion des erkenntnistheoretischen Status von Texten, bevor am Schlus einige allgemeine Kriterien zum Verfahren der Textinterpretation angefuhrt werden. Der Beitrag votiert dafur, das Forschungsziel nicht auf die Rekonstruktion einer je besonderen U…

Sauerstoffversorgung trotz Atemstillstandes

1994

Botulinum A and the light chain of tetanus toxins inhibit distinct stages of Mg.ATP-dependent catecholamine exocytosis from permeabilised chromaffin …

1994

Susceptibilities of Mg.ATP-independent and Mg.ATP-requiring components of catecholamine secretion from digitonin-permeabilised chromaffin cells to inhibition by Clostridial botulinum type A and tetanus toxins were investigated. These toxins are Zn(2+)-dependent proteases which specifically cleave the 25-kDa synaptosomal-associated protein (SNAP-25) and vesicle-associated membrane protein (VAMP) II, respectively. When applied to permeabilised chromaffin cells they rapidly inhibited secretion in the presence of Mg.ATP but the catecholamine released in the absence of Mg.ATP, thought to represent fusion of primed granules, was not perturbed. The toxins can exert their effects per se in the abse…

Effect of growth regulators onin vitro propagation ofFicus benjamina cv. Exotica

1994

Stem internodes with axillary buds were excised from 5-year old trees ofFicus benjamina cv. Exotica. The effect of 6-benzylaminopurine (BAP), gibberellic acid (GA3), indole-3-acetic acid (IAA), naphthaleneacetic acid (NAA), and 2,4-dichlorophenoxyacetic acid (2,4-D) on shoot growth and proliferationin vitro was investigated. Multiple shoots were developed after 3–4 weeks from stem internodes with axillary buds incubated in Murashige and Skoog (MS) medium supplemented with phloroglucinol (PG) and BAP. Optimum shoot proliferation took place in the presence of 1.0 mg l−1 BAP. Shoots obtained could be elongated in a medium with 0.5 mg l−1 GA3 prior to their rooting. The root initiation was succ…

Identification of a putative membrane-inserted segment in the alpha-toxin of Staphylococcus aureus.

1994

To gain a fuller understanding of the regions of the Staphylococcus aureus alpha-toxin important in pore formation, we have used Forster dipole-dipole energy transfer to demonstrate that a central glycine-rich region of alpha-toxin (the so-called "hinge" region) inserts deeply into the bilayer on association of toxin with liposomes. Mutant alpha-toxins with unique cysteine (C) residues at positions 69 and 130 [Palmer, M., et al. (1993) J. Biol. Chem. 268, 11959) were reacted with the C-specific fluorophore acrylodan, which acted as an energy donor. The chosen acceptor was N-(7-nitrobenz-2-oxa-13- diazol-4-yl)-1,2-bis(hexadecanoyl)-sn-glycero-3-phosphoethanolamin e (NBD-PE). Measurement of t…

Aberrant arrested in maturation neuromuscular junctions in centronuclear myopathy

1994

Unusual ultrastructural changes of the nerve terminals have been found in an infant born with severe, fatal XLR form of centronuclear myopathy. Aberrant neuromuscular junctions in myotubes decorated by N-CAM were observed. The junction changes were manifested by simplification of postsynaptic membrane and paucity of secondary synaptic clefts. These resembles fetal neuromuscular junctions. The findings suggest that the expression of N-CAM by arrested myotubes may be promoted by abnormal nerve-muscle cell interactions, induced by motor endplate immaturity.

The Ratio R of hadronic and electronic Z widths and the strong coupling constant alpha-s

1994

Abstract We review the relation between the ratio of hadronic and electronic Z widths, R = Γ( Z → q q )/Γ( Z → e + e − ) and the strong coupling constant at the Z mass, αs. The theoretical uncertainty of αs derived from R is estimated to be Δα s = ±0.002 (electroweak) ± 0.002 (QCD) −0.003 +0.004 (m top , m Higgs ) .

Constraint qualifications and Lagrange multipliers in nondifferentiable programming problems

1994

In this paper, we present several constraint qualifications, and we show that these conditions guarantee the nonvacuity and the boundedness of the Lagrange multiplier sets for general nondifferentiable programming problems. The relationships with various constraint qualifications are investigated.

Foreed flushing of branch segments as a method for obtaining reactive explants of mature Quercus robur trees for micropropagation

1994

The aim of this study was to micropropagate mature Quercus robur L. trees when material retaining physiologically juvenile characteristics (stump sprouts, epicormic shoots) is not available. Branch segments from 70–300 year-old trees were force-flushed and the flushed, partially rejuvenated or reinvigorated shoots were used as a source of explants for establishment of cultures. In vitro establishment and multiplication was achieved with seven of the eight selected trees. The proliferation capacity of cultures of vertically placed explants declined after several subcultures, but efficient shoot multiplication was achieved by culturing decapitated shoots placed horizontally on GD medium suppl…

Antiasthmatic acetophenones - an in vivo study on structure activity relationship.

1994

The recently isolated acetophenone glucoside androsin, as the major antiasthmatic principle of Picrorhiza kurroa Royle ex Benth. (Scrophulariaceae), was used as a lead compound for detailed structure-activity relationship studies. More than 25 synthesized or commercially available acetophenones with modified substitution patterns were screened in the Plethysmographic guinea pig model using PAF and/or ovalbumin as challenging agents for the generation of bronchial constriction. Whereas the aglycones in most cases were more effective than the corresponding glycosides, substitution patterns in position 3 and 4 of the phenyl ring and the keto function attached to the phenyl ring were found to b…

New representation of two-loop propagator and vertex functions

1994

We present a new method of calculating scalar propagator and vertex functions in the two-loop approximation, for arbitrary masses of particles. It is based on a double integral representation, suitable for numerical evaluation. Real and imaginary parts of the diagrams are calculated separately, so that there is no need to use complex arithmetics in the numerical program.

Bounding effective operators at the one-loop level: the case of four-fermion neutrino interactions

1994

The contributions of non-standard four-neutrino contact interactions to electroweak observables are considered at the one-loop level by using the effective quantum field theory. The analysis is done in terms of three unknown parameters: the strength of the non-standard neutrino interactions, $\tilde{F}$, an additional derivative coupling needed to renormalize the divergent contributions that appear when the four-neutrino interactions are used at the loop level and a non-standard non-derivative $Z$-${\bar\nu} \nu$ coupling. Then, the precise measurements of the invisible width of the $Z$-boson at LEP and the data on the neutrino deep-inelastic scattering yield the result $\tilde{F} = (-100 \…

Ansiotropy in friction and molecular stick-slip motion

1994

<title>Flexible neuroendoscopy with laser and microsystem technique</title>

1994

The use of flexible neuroendoscopic techniques in neurosurgical procedures is routinely performed in the spinal canal and in the intracranial subdural space. Treated entities are syringomyelia, tumors with concomitant syrinxes in spinal cord, cystic legions in the subdural and subarachnoid space in the spinal canal as myelomeningoceles.© (1994) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.

Quantum groups and deformed special relativity

1994

The structure and properties of possible $q$-Minkowski spaces is discussed, and the corresponding non-commutative differential calculi are developed in detail and compared with already existing proposals. This is done by stressing its covariance properties as described by appropriate reflection equations. Some isomorphisms among the space-time and derivative algebras are demonstrated, and their representations are described briefly. Finally, some physical consequences and open problems are discussed.

L'évaluation sensorielle: une technologie statistique?

1994

International audience

Male coloration and species recognition in sympatric flycatchers

1994

Currently favoured views for explaining ornaments in males emphasize female preference such that females benefit from increased offspring production, good genes of the offspring, or the attractiveness of sons. Results from long-term studies in the pied flycatcher Ficedula hypoleuca suggest that factors associated with species recognition may also be important for male coloration. In sympatry the collared flycatcher F. albicollis is dominant in competition for nesting sites over the pied flycatcher. Bright pied flycatcher males resemble collared flycatcher males and suffer from interspecific interference, whereas dull and female-like males can acquire nesting sites close to those of the coll…

A model study of nuclear structure functions

1994

We calculate the structure function for a deuteron using the hadronic quark cluster decomposition. By assuming that nuclei might be composed of quasi deuterons, we study their structure functions. The procedure enables a quantum mechanical parametrization of various scenarios, among them nuclear dynamics and nucleon swelling. Moreover it is specially suited to study quark exchange effects. We show, within a scheme where perturbative evolution effects are minimized, that the region around x=1 is very sensitive to these two mechanisms and their effects can be disentangled.

Excitonic model for second-order resonant Raman scattering.

1994

A theoretical model for second-order resonant Raman scattering is presented. The effect of Coulomb interaction between electrons and holes is fully taken into account in the framework of the effective-mass approximation. By introducing discrete and continuous excitonic intermediate states in the Raman process, an explicit expression for the Raman scattering efficiency is given for long-range Fr\"ohlich electron-phonon interaction. The model developed can be used to evaluate Raman profiles around the resonant region. A closed-form expression for all matrix elements of the exciton-phonon interaction is obtained once the Coulomb problem for the relative electron-hole motion is separated in sph…

Ikääntyvien opiskelu ja koulutus

1994

Right up to the present, study by the elderly has focused mainly on general adult education. Consequently, marginalisation in this area has been particularly harmful to this section of the population, the people who have received the least education in our society. The motives and points of departure concerning the elderly have not yet been clearly formulated in adult education. This state of affairs is exemplified by the facts that adult education policy statements almost entirely by-pass the issue of education for the elderly and that an educational policy aimed at the elderly simply does not exist. The elderly can no longer be expected to be satisfied with mere activities for the sake of…

THE OCCURRENCE OF SENECIO VULGARIS L. VAR. VULGARIS AND S. × HELWINGII BEGER EX HEGI (S. VULGARIS × S. VERNALIS WALDST. ET KIT.) IN ISRAEL

1994

Common Groundsel (Senecio vulgarisL. var.vulgaris(2n = 40)) is widespread in the northern hemisphere. In Israel, judging from a herbarium survey, records taken from the Israel Plant Information Center (ROTEM), and field studies, it has a restricted and widely disjunct pattern of geographical distribution, and, thus, is another example of the comparatively large group of weeds in Israel which are extremely stenochorous. The remarkable gaps in its distribution, from the Upper Golan to Mt. Carmel and to the Jerusalem area, are considered primarily to be the result of paleoclimatic changes, whereas its occurrence outside these centers of distribution is probably related to long-distance dispers…

SELFING ABILITY AND MALE STERILITY IN SENECIO VERNALIS WALDST. ET KIT. (ASTERACEAE) FROM ISRAEL

1994

Two major findings relating to the breeding system of Senecio vernalis from Israel are reported. First, isolation experiments failed to confirm the existence of a widespread, truly self-compatible and predominantly self-pollinating breeding system in Israeli populations of S. vernalis. However, a single S. vernalis plant derived from a natural stand at Jerusalem was found to be self- compatible and strongly self-pollinating. In its progeny, there were signs of inbreeding depression commonly associated with selfed offspring of outbreeding species. Selfing ability ratios in this progeny indicate a single dominant gene for selfing ability in S. vernalis. The implications of these observations …

Real filter based on Mellin radial harmonics for scale-invariant pattern recognition.

1994

Several theoretical and experimental studies are developed in order to simplify the construction of filters based on Mellin radial harmonics (MRH) for scale-invariant pattern recognition. A real filter based on MRH is designed. The impulse response of the filter is a hermitic function, obtained by a suitable modification of a MRH component. This real filter has the same scale invariance as the conventional complex MRH filters, with the main advantage of its simplicity. Both computer simulations and optical experiments are presented.