Effects of hydrazyl group containing drugs on leucocyte functions: an immunoregulatory model for the hydralazine-induced lupus-like syndrome.

1985

Isoniazid (INH) and hydralazine (HYD) are transglutaminase (TGase, E.C.2.3.2.13.) substrates containing catalytically recruitable hydrazyl groups. Since they can be expected to inhibit TGase-mediated cell functions by competing with physiological substrates, their effect upon allogeneically and lectin-induced proliferation of mononucleocytes and upon zymosan-induced chemiluminescence of phagocytes was studied. Both compounds inhibited chemiluminescence in a dose-dependent manner. ID50 of HYD was consistently below 20 microM, while that of INH was above 120 microM. Proliferation of immunocompetent cells was suppressed by HYD with an ID50 of 60 microM, INH was inhibitory only above 5000 micro…

Notas de flora maestracense, IV

1985

Se da noticia de 36 táxones de plantas vasculares presentes en el sector corológico maestracense, raras o de interés, principalmente para alguna de las provincias valencianas; resultando 20 de ellas nuevas para la flora provincial de Valencia, 2 para la de castellón y 3 para la de Teruel. We comment 36 interesting taxa from the eastern Iberian region, 20 of which are new records for the province of Valencia, 2 for the province of Castellón and 3 for the province of Teruel. aguilel@uv.es

Estudio comparativo de los diversos factores que afectan al aislamiento de Salmonella a partir de aguas : determinación de resistencias a antibiótico…

1985

Электрохромизм и локализация носителей заряда в триоксиде вольфрама

1985

Advisor: Лусис, Андрей

Interdependence Between Tool Fracture and Wear

1985

Wear and fracture are the main causes of tool scrapping. However fracture plays a major role for increasing values of the hardness and brittleness of tool materials or when low-cobalt tungsten carbides are used or in interrupted cutting conditions where it is the most relevant factor for tool scrapping. In order to obtain the optimal values of the cutting speed both these factors should be considered. The hypothesis of stochastic independence among them simplifies the mathematical formulation of the optimization problem; but experimental investigations do not agree with this assumption and, as a matter of fact, the probability density function of tool fracture results to be dependent on the…

El coneixement humà I [Pròleg]

1985

El coneixement humà. El seu abast i els seus límits està considerada com la darrera obra sistemàtica de filosofia de B. Russell; ·fou publicada el 1948, quan Russell tenia 76 anys, just el mateix any que, a força de nedar, va salvar la seua vida d'un accident d'avió precipitat al mar. Posteriorment a aquesta data, Russell publica obres de temes d'allò més divers, entre les quals cal destacar una de filosòficament important: My philosophical development (1959). L'obra, però, no intenta d'ésser un resum final o sistema del pensament de l'autor. En primer lloc, perquè el filòsof anglès la va escriure com una obra més, com el resultat de les seues darreres investigacions, que afegien als estudi…

Veränderung der hypophysären und testikulären Rezeptoren unter der Langzeitbehandlung von Ratten mit einem LHRH-Agonisten (Buserelin)

1985

In der Urologie wird die androgenhemmende Wirkung von LHRH-Agonisten zur palliativen Therapie des testosteronabhangigen Prostatakarzinoms (Wenderoth und Jacobi 1983) angewandt. Wenn LHRH-Analoga taglich durch Injektion oder Nasal-spray in hoher Dosis verabreicht werden, hemmen sie die Gonadotropinfreisetzung und die Testosteron-Sekretion. Diese Wirkung wird uber eine initiale Stimulations-phase (supraphysiologische Gonadotropin-Freisetzung) ausgelost. Die Mechanismen der Hemmwirkung von LHRH-Analoga bei langerer Behandlung werden durch Veranderungen der Steroidbiosynthese sowie der LHRH-Rezeptoren der Hypophyse und der LH-Rezeptoren der Leydig-Zellen erklart (Sandow 1983). Eine zusatzliche …

Le syndrome du diplôme et le chômage des jeunes diplômés : le cas du Cameroun

1985

référence interne : 85003

Determination of molecular weights and Stokes' radii of non-denatured proteins by polyacrylamide gradient gel electrophoresis 3. Estimation of the up…

1985

Studying the separation behavior of various native carbonic anhydrase isozymes from mammalian erythrocytes we found that the migration of these enzymes differs from that of the marker proteins commonly used in gradient gel electrophoresis. In alkaline buffer systems the enzymes from human, bovine, rabbit, and canine erythrocytes start to migrate with a size apparently 6 to 12 times larger than their monomeric size, then gradually lose in apparent size and finally end up in a size equivalent to their monomeric mol mass. We determined the monomeric mol mass of the various carbonic anhydrase forms to be 23 000 to 39 000 (g/mol). These values are in accordance with different data in the literat…

Estudio de los polisacáridos del quercus suber

1985

119Sn mössbauer, IR, 1H NMR spectroscopic and thermal decomposition studies on organotin(IV) adducts with glycylglycine

1985

Abstract The complexes R2SnCl2·(H2glygly), (H2glygly = glycylglycine) (R = Me, Bun, Octn, Ph) and RSnCl3·(H2glygly)

Хозяйственный механизм производства и обращения товаров народного потребления

1985

Межвузовский сборник содержит статьи, посвященные актуальным проблемам совершенствования хозяйственного механизма в отраслях промышленности и торговли.

Desarrollo de la dentición temporal : análisis de la cronología y secuencia eruptiva. Un estudio sobre 628 niños

1985

La Hermandad de Andalucía durante la minoría de Alfonso XI: nueva aportación a documental

1985

La revisión fichteana de la filosfía de Kant

1985

La exegética filosófica está generalmente de acuerdo en situar el origen de la especulación de Fichte en las doctrinas del Kant crítico. Ello ha dado lugar a una proliferación de estudios sobre el significado del pensamiento fichtcano en relación con el idealismo trascendental. Para unos intérpretes. la filosofía de Fichtc constituye et desarrollo natural y obligado de las tesis centrales del pensador de Konisherg. Para otros problemas a que da respuesta el idealismo fichteano significan el fracaso de la Crítica para solucionar los grandes temas que ella misma había suscitado. Algunos piensan que la Doctrina de la ciencia prepara ya los grandes lineamientos dentro de los cuales se moverá la…

Ideologicamente disponibles

1985

Evidence for a surface self-cleaning sputtering mechanism in fast atom bombardment mass spectrometry

1985

Evidence for a surface self-cleaning sputtering mechanism in fast atom bombardment mass spectrometry involving significant sputtering from the bulk of the glycerol matrix has been obtained from (a) the time dependence of sample ion abundances and chemical noise for bioorganic compounds, (b) determinations of the sputtering volume in glycerol solution, and (c) studies of in situ chemical and biochemical reactions. The relevance of these results for optimal sample/matrix preparation in analytical applications is pointed out.

Profesore Helēna Mauriņa: personālais bibliogrāfiskais rādītājs

1985

Saturs: Priekšvārds. Prof. R. Kondratovičs. Profesorei Helēnai Mauriņai - 60. Profesores H. Mauriņas publicētie darbi (1948.-1984.) Profesores H. Mauriņas rediģētie darbi. Profesorei H. Mauriņai izsniegtās (publicētās) autorapliecības. Profesores H. Mauriņas vadītās disertācijas. Raksti par profesori H. Mauriņu. Intervijas un sarunas ar profesori H. Mauriņu. Profesores H. Mauriņas publicēto darbu alfabētiskais rādītājs. Personu rādītājs.

La beneficencia eclesiástica en la Barcelona del XVII: La Pía Almoina. 1655-1669

1985

France : system of education

1985

International audience

Doppler- und B-Bild-Ultraschall in der Chirurgie komplizierter Nierenbecken- und Kelchausgußsteine

1985

Evidence for Direct Binding of the First Component of Complement, C1, to Outer Membrane Proteins from Salmonella minnesota

1985

The outer membrane of gram-negative bacteria consists of a tight lattice of lipopolysaccharides (LPS), phospholipids, and proteins. It has been shown in E. coli and S. typhimurium that LPS molecules are exclusively localized in the outer layer of the outer membrane (Muhlradt and Golecki 1975; Smit et al. 1975; Funatura and Nikaido 1980). Localization of proteins in the outer membrane is also indicated by the fact that various major outer membrane proteins in association with LPS, serve as receptors for phages (Datta et al. 1977; Mu-TOH et al. 1978; Henning and Jann 1979; Yu and Mizushima 1982) and colicins (Kadner et al. 1979; Konisky 1979).

Le Commissioni d'inchiesta, con particolare riferimento alle Commissioni consiliari e alle Commissioni istituite dall'Assemblea regionale siciliana

1985

the essay describes the parliamentary investigative power and deals with the specific aspect of the investigative commissions set up by the Sicilian regional assembly, to define their powers in relation to those at national level, so much so that they can be assimilated to the investigative commissions, without therefore powers of the judiciary and former parliamentary committees I'm coming! 82 of the Constitution

Centralismo y autonomía municipal en Orihuela: de Fernando el Católico al "viraje filipino"

1985

Alumoksany jako składniki tytanowo-glinowych katalizatorów polimeryzacji etylenu

1985

Nasennebenhöhlen und retromaxillärer Raum

1985

Die Anlage der Nasenhohle geht von der Riechplatte und den Riechgrubchen aus, die als Blindsacke in das Dach der Mundhohle durchbrechen und auf diese Weise die Primitivchoanen und die Erstanlage der Nasenhohle bilden. Zwischen dieser primitiven paarigen Nasenanlage und der Mundhohle liegt als horizontale Platte der Gaumen, der gleichzeitig den Nasenboden bildet. Aus den lateral liegenden Oberkieferfortsatzen folgt die Ausformung des sekundaren Gaumens. Aus dem Os incisivum (Zwischenkieferknochen nach Goethe) entwickelt sich der Vordergaumen. Die Gaumenplatten verwachsen mit dem Nasenseptum; erst dann entstehen die Nasenmuscheln, Nasengange und Nasennebenhohlen.

Effects of ethanol and acetaldehyde on phagocytic functions

1985

Although a number of skin diseases are characterized by the presence of an increased number of phagocytes in their lesions, the effects of alcohol on phagocytic functions are not clearly understood. Therefore, we measured the influence of ethanol and acetaldehyde on the generation of oxygen radicals, chemotaxis and the release of lysosomal enzymes from human phagocytes. We added 0.03%-3% ethanol and 0.005%-0.25% acetaldehyde to cell cultures. We found that both ethanol and acetaldehyde suppressed the generation of oxygen radicals from granulocytes and monocytes; the ID50 was achieved at concentrations of approximately 0.25% for ethanol and 0.03% for acetaldehyde. A significant inhibition of…

Circuit et circulation, une fausse analogie

1985

International audience

C.K.C. Newsletter: Reports of Activities 1982-1984

1985

Residuenanalyse des Unabhängigkeitsmodells Zweier Kategorialer Variablen

1985

For the ‘cellwise’ analysis of independence of two categorial variables, Haberman (1973) proposes the method of ‘adjusted residuals’. Fuchs and Kenett (1980) use (the absolute value of) the maximal adjusted residual as a measure for the deviation from the null hypothesis.

Felipe IV y el Reino de Valencia (1621-1634): Relaciones con la Monarquía, orden público y problemática de la ciudad

1985

El parasitismo en la obra de José Eugenio Olavide : dermatología general y clínica iconográfica de enfermedades de la piel o dermatosis (1871)

1985

En el siglo XIX, la idea de un pathsito vegetal como origen de alguna enfermedad comenzó a cristalizar en torno a la década dé los 30. Su inicio puede fijarse en los trabajos que sobre la muscardina del gusano de seda realizó Agostino Bassi, quien descubrió que dicha enfermedad era causada por un hongo parà.sito. Este hecho le llevo a formular la teoría del origen parasitario de las enfermedades infecciosas. Desde entonces, y hasta los arios 50, se aceptó la etiología fúngica de algunas enfermedades, pero no la teoría de los gérmenes como causa del resto de las enfermedades infecciosas.

Estudios químico-analíticos para la determinación de Biguanidas en preparados farmacéuticos

1985

Biochemistry and Molecular Biology of DNA Replication in Yeast

1985

For the past two decades, the study of the mechanism of DNA replication has been focused mainly on the chromosomes of the simple prokaryotes and their viruses (1). The complexity of the eukaryotic genome and multiple levels of control during the replication of eukaryotic chromosomes have until recently prevented similar studies. In recent years, a lower eukaryote, the yeast Saccharomyces cerevisiae, has become a major focus of efforts in molecular biology. In this chapter, I will briefly review accomplishments in this area. Yeast is an ideal model system for studies on the structure and replication of the eukaryotic chromosome. Yeast cells are easy to grow and study biochemically. Genetic a…

Données récentes sur l'urbanisme d'Autun (Augustodunum) (Saône-et-Loire)

1985

International audience

Antimykotische Wirkstoffe, 18. Mitt. Aromatisch substituierte 2-(4-Toluidino)pyrimidine

1985

Die Kondensation von 4-Tolylguanidin (1) mit den aromatische und heteroaromatische Substituenten tragenden β-Diketonen 2a–d fuhrt zu den korrespondierend substituierten 2-(4-Toluidino)pyrimidinen 3a–d. Antimycotic Agents, XVIII: Aromatically Substituted 2-(4-Toluidino)pyrimidines Condensation of 4-tolylguanidine (1) with the β-diketones 2a–d bearing aromatic or heteroaromatic substituents leads to the 2-(4-toluidino)pyrimidines 3a–d.