showing 36 of ~574560 from 574555 documents
Covid-19 in Philadelphia-negative myeloproliferative neoplasms: a GIMEMA survey on incidence, clinical management and vaccine
2022
Effect of pharmacological interventions and placebo on liver Histology in nonalcoholic steatohepatitis: A network meta-analysis
2022
Background: The aims of this study were to quantify the histological improvement and its risk factors in patients with NASH enrolled in the placebo arms of randomized controlled trials (RCTs), and to indirectly compare the effect of several investigational drugs for NASH on validated histological outcomes.Data synthesis: A comprehensive search was conducted to detect phase 2 and 3 RCTs comparing pharmacological interventions in patients with NASH. According to Food and Drug Administra-tion (FDA) recommendations, primary outcomes included: 1) NASH resolution without wors-ening of fibrosis; 2) At least 1-point reduction in fibrosis without worsening of NASH. Meta -analysis and meta-regression…
LE RICADUTE DEGLI STATI DI EMERGENZA SANITARIA E BELLICA SULL’ORDINAMENTO SPORTIVO E IL PRINCIPIO DI NEUTRALITÀ DELLO SPORT
2022
Il lavoro affronta l’interrogativo se possa parlarsi, in riferimento alla pandemia ed alla guerra in atto, di stato di eccezione e/o di emergenza in seno all’ordinamento sportivo, così da giustificare una compressione dei suoi principi fondamentali e, tra questi, in particolare, quello di neutralità politica e, correlativamente l'interrogativo se spetti all’ordinamento sportivo il potere di impedire al suo interno le ricadute derivanti dalla dichiarazione dello stato di emergenza operata dall’ordinamento giuridico statale sotto il profilo della compressione, in primis, della libertà fondamentale alla pratica dello sport.
Longitudinal association of handgrip strength with all-cause and cardiovascular mortality in older adults using a causal framework.
2022
To date, there is no study addressing the time-varying confounding bias in the association of handgrip strength (HGS) with all-cause or cardiovascular mortality. Therefore, we conducted marginal structural models (MSM) to provide causal estimations on the associations of HGS with all-cause and cardiovascular mortality in a representative sample of adults aged 50 years or older. Data from 29 countries including 121,116 participants (276,994 observations; mean age 63.7 years; 56.3 % women) free from prior heart attack or stroke were retrieved from consecutive waves of the Survey of Health, Ageing and Retirement in Europe (SHARE). During a median of 7.7 years follow-up (interquartile range 3.8…
Development of the Health Promoting Sports Club - National Audit Tool
2022
Abstract Background Sports clubs have requested support from national governing authorities to invest in health promotion (HP), by developing policies, guidelines and dedicated funding. This manuscript outlines the development of a national audit tool to review policies development and implementation to support HP in sports clubs. Methods A 5-step process was undertaken by an international project team: (1) a rapid literature review to identify items assessing policies in physical activity, HP and sports, (2) a thematic analysis to categorize items, (3) a Delphi method to analyze item relevance, country specificity, reformulation, validation and organization, (4) face validity through an on…
Examining the Mediating Role of Attachment Style in the Relationship between Childhood Maltreatment and Borderline Personality Disorder in Adolescent…
2022
The Trasversale Sicula. Themes and action research projects in sensitive Mediterranean areas
2022
There are many sensitive territories located in disadvantaged areas of the Mediterranean where depopulation has been a significant consequence of their economic and demographic decline. This has led to the gradual flight of young people and the disappearance of certain essential services. The conservation of resources is a topic of growing interest in Europe. It is necessary to rethink a new vision concerning the territory of small towns. Within this framework, this action research project aims to define a new collective sensibility, full of resources and history, throughout the territory of the Trasversale Sicula. The narrative of a new imaginary of the Sicilian hinterland is the foundatio…
Un mondo senza confini, un potere senza limiti. Temi e retoriche identitarie dell’«eccezionalismo» ateniese
2022
Partendo dalla categoria politica di “eccezionalismo”, che è stata utilizzata per descrivere la politica estera degli Stati Uniti, soprattutto nel XX secolo, questo paper propone una analisi comparata con la politica ateniese di V secolo, soprattutto durante il suo impero marittimo: in tale contesto la nozione di “eccezionalismo” sembra adatta per comprendere alcuni aspetti della sua politica e i rapporti tra “eccezionalismo” e democrazia. Starting with the political category of 'exceptionalism', which has been used to describe US foreign policy, especially in the 20th century, this paper proposes a comparative analysis with 5th century Athenian policy, especially during its maritime empire…
Green composites based on biodegradable polymers and anchovy (Engraulis Encrasicolus) waste suitable for 3D printing applications
2022
Every day large amounts of fish waste are produced and grossly discarded in markets around the world causing environmental and hygiene issue. The use of these scraps for the production of materials with higher added value can definitely contributed to solve this problem. In this work, 10% and 20% of anchovy fishbone powder (EE), obtained by market waste, were microbiological and mechanical tested and subsequently added to polylactic acid (PLA) and to a commercial blend of biodegradable co-polyesters (Mater-Bi®). Rheological characterization suggests the potential printability of all prepared composites filaments. 10% EE filled composites showed outstanding printability. Morphological analys…
Dry chlorination of spent nickel metal hydride battery waste for water leaching of battery metals and rare earth elements
2022
An efficient leaching process was developed for nickel, cobalt, and the rare earth elements (REEs) from spent nickel metal hydride (NiMH) battery waste. The process involves dry chlorination with ammonium chloride in low temperature to produce water-soluble chlorinated compounds, followed by simple water leaching. The factors affecting the conversion and solubilization were studied, including the amount of ammonium chloride, residence time and temperature in dry chlorination, and solid to liquid ratio, time and temperature in water leaching. As a result, the dry chlorination process was found to produce ammonium and chloride containing products, depending on the temperature of the process: …
The regulation of efferocytosis signaling pathways and adipose tissue homeostasis in physiological conditions and obesity: Current understanding and …
2022
Obesity is associated with changes in the resolution of acute inflammation that contribute to the clinical complications. The exact mechanisms underlying unresolved inflammation in obesity are not fully understood. Adipocyte death leads to pro-inflammatory adipose tissue macrophages, stimulating additional adipocyte apoptosis. Thus, a complex and tightly regulated process to inhibit inflammation and maintain homeostasis after adipocyte apoptosis is needed to maintain health. In normal condition, a specialized phagocytic process (efferocytosis) performs this function, clearing necrotic and apoptotic cells (ACs) and controlling inflammation. For efficient and continued efferocytosis, phagocyt…
Sampling properties of the Bayesian posterior mean with an application to WALS estimation
2022
Many statistical and econometric learning methods rely on Bayesian ideas, often applied or reinterpreted in a frequentist setting. Two leading examples are shrinkage estimators and model averaging estimators, such as weighted-average least squares (WALS). In many instances, the accuracy of these learning methods in repeated samples is assessed using the variance of the posterior distribution of the parameters of interest given the data. This may be permissible when the sample size is large because, under the conditions of the Bernstein--von Mises theorem, the posterior variance agrees asymptotically with the frequentist variance. In finite samples, however, things are less clear. In this pa…
La promozione del benessere delle persone over 60 attraverso l’incremento delle competenze digitali: uno studio sperimentale preliminare
2022
Nell’a.a. 2021/2022 si è svolto il progetto di ricerca “Prevenzione degli incidenti domestici e promozione dell'attività fisica over 60”, al fine di promuovere il benessere di 8 gruppi di persone over 60 (218 in totale) della provincia di Palermo. In seno al progetto, la somministrazione del questionario DigComp ha permesso l’individuazione di un gruppo di esperimento (22 persone) e uno di controllo (24 persone) aventi un’età media di 70 anni (cluster sampling). Il gruppo con scarse competenze digitali ha seguito i moduli formativi a distanza, mentre il gruppo che ha mostrato buone competenze digitali ha partecipato alle sessioni formative in presenza. Si è ipotizzato che al termine dell’in…
Investigating the Effects of Differential Learning on Golfers’ Pitching Performance as a Function of Handicap
2022
Traditionally, golf instruction has been oriented toward imitation of role models, guided by errors that surround a channel of supposedly correct repetition. Recent motor learning approaches relying on the dynamics of living systems suggest the inclusion of additional noise during practice for supporting players’ movement exploration and improving adaptability that in consequence will lead to increased performance. While the effectiveness of this approach has now been demonstrated in many sports, research exploring the effects of differential learning (DL) in golf is scarce, especially when considering different shot distances and players with various handicap levels. Therefore, the p…
Association between depression and subjective cognitive complaints in 47 low- and middle-income countries
2022
People with depression and subjective cognitive complaints (SCC) may be at particularly high risk for developing dementia. However, to date, studies on depression and SCC are limited mainly to single high-income countries. Thus, the aim of the present study was to investigate the association between depression and SCC in adults from low- and middle-income countries (LMICs). Cross-sectional, community-based data were analyzed from the World Health Survey. Two questions on subjective memory and learning complaints in the past 30 days were used to create a SCC scale ranging from 0 (No SCC) to 100 (worse SCC). ICD-10 Diagnostic Criteria for Research was used for the diagnosis of subsyndromal de…
Effects of osteopathic manipulative treatment of the pivots on lower limb function in young professional football players
2022
Introduction: The most frequent injuries in professional soccer players are those pertinent to the lower limbs. In particular, strains of the hamstrings and ligamentous injuries of the knee. Therefore, preventive measures are aimed to reduce such events. We aimed to investigate if an osteopathic manipulative treatment (OMT) of the pivots could improve lower limb function in young professional football players. Methods: Thirty-eight young male professional football players were recruited (mean age 17.8 +/- 0.44 years). These were randomly assigned to an OMT or control group (n 1/4 20 and 18, respectively). Both groups underwent osteopathic evaluation. A sit-and-reach test, a vertical jump te…
Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial
2022
AbstractThe STEP 5 trial assessed the efficacy and safety of once-weekly subcutaneous semaglutide 2.4 mg versus placebo (both plus behavioral intervention) for long-term treatment of adults with obesity, or overweight with at least one weight-related comorbidity, without diabetes. The co-primary endpoints were the percentage change in body weight and achievement of weight loss of ≥5% at week 104. Efficacy was assessed among all randomized participants regardless of treatment discontinuation or rescue intervention. From 5 October 2018 to 1 February 2019, 304 participants were randomly assigned to semaglutide 2.4 mg (n = 152) or placebo (n = 152), 92.8% of whom completed the trial (attended t…
Lowered nutritional quality of prey decrease the growth and biomolecule content of rainbow trout fry
2022
Diet quality is crucial for the development of offspring. Here, we examined how the nutritional quality of prey affects somatic growth and the lipid, carbohydrate, protein, amino acid, and polyunsaturated fatty acid content of rainbow trout (Oncorhynchus mykiss) fry using a three-trophic-level experimental setup. Diets differed especially in their content of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which are physiologically essential polyunsaturated fatty acids for a fish fry. Trout were fed with an artificial diet (fish feed, DHA-rich), marine zooplankton diet (krill/Mysis, DHA-rich), or freshwater zooplankton diet (Daphnia, Cladocera, DHA-deficient). The Daphnia were gr…
Research Evidence and Implications on Migration Phenomena in Europe
2022
This book provides a summary overview of the activities carried out by the Diversity and Migration Lab, which was set up within the scope of the FORTHEM international Alliance (Fostering Outreach within European Regions, Transnational Higher Education and Mobility), and concluded in September 2022.
Randazzo nell'opera di Walter Leopold
2022
In 2021 a group of researchers and students on both sides of the Atlantic Ocean toasted ten years of The Medieval Kingdom of Sicily Image Database project (https://kos.aahvs.duke.edu/). This collection of historical images of medieval monuments in Southern Italy was launched in 2011. Its purpose was to document the complex history of this highly diverse patrimony with visual documents that testify to the cultural richness of the Italian South. Online since October 2016, the project was fostered by Caroline Bruzelius at Duke University (NC). It has now become an invaluable research and study tool thanks to her charisma and her indefatigable enthusiasm in the face of ever-new intellectual cha…
A homozygous MED11 C-terminal variant causes a lethal neurodegenerative disease.
2022
Purpose: The mediator (MED) multisubunit-complex modulates the activity of the transcriptional machinery, and genetic defects in different MED subunits (17, 20, 27) have been implicated in neurologic diseases. In this study, we identified a recurrent homozygous variant in MED11 (c.325C>T; p.Arg109Ter) in 7 affected individuals from 5 unrelated families. Methods: To investigate the genetic cause of the disease, exome or genome sequencing were performed in 5 unrelated families identified via different research networks and Matchmaker Exchange. Deep clinical and brain imaging evaluations were performed by clinical pediatric neurologists and neuroradiologists. The functional effect of the ca…
Evidence for spatiotemporal shift in demersal fishery management priority areas in the western Mediterranean
2022
14 pages, 10 figures, 2 tables, 1 appendix
Per una democrazia liberale interventista
2022
In this article I'argument in favor of a liberal and interventionist democracy
Variable Friction Dampers (VFD) for a modulated mitigation of the seismic response of framed structures: Characteristics and design criteria
2022
In this paper a new approach for the energy dissipation is discussed based on the use of Variable Friction Dampers (VFDs). The VFD device is borrowed from braking systems mechanical engineering, able to modulate its capability of dissipation, providing a constant pure friction force coupled with an additional (variable) damping force with the increasing of the displacement. Resorting to a previous study, the characteristics and the efficiency of the “braking” system in terms of reduction of the displacements and the restoring forces is described for SDOF systems under seismic excitations and compared with the performances achievable by classic constant friction dampers (CFDs). Then, a desig…
Hydrothermal liquefaction of wet biomass in batch reactors: Critical assessment of the role of operating parameters as a function of the nature of th…
2022
A scientometric analysis of articles published from 1986 to 2022 on batch hydrothermal liquefaction of microalgae, macroalgae, lignocellulosic biomass, sewage sludge and organic wastes in water was performed. We found that biocrude yield can be correlated with the kinetic severity factor (KSF) and scattering of experimental data increases in the supercritical region probably for uncertainty in the medium density affecting the kinetics of reactions involved in the process. The level of correlation and the yield increased when fast heating rates of the reactor, higher than 25 ◦C/min, were adopted. Energy recovery of biocrude obtained in fast heating experiments changes linearly with biocrude …
Is more competition better? Retail electricity prices and switching rates in the European Union.
2022
The European Union (EU) promotes the liberalization of retail electricity markets to achieve lower prices, diversified offers, greater customer participation, and sustainable consumption behaviours. While retail competition has been a reality in most EU member states, most studies find that retail competition is suitable for large customers, but the evidence on small customers is inconclusive. We analyze data on electricity prices and switching rates in 27 EU member states and the UK from 2000 to 2019. We find that retail competition is associated with lower prices and that the effect of full liberalization is greater than that of partial liberalization.
Provenienze e possessori degli incunaboli di Agrigento: uno sguardo retrospettivo
2022
Based on the history of the Biblioteca Lucchesiana and of the Library of the Episcopal Seminary in Agrigento, an account is given on the provenance and ownership data derived from the catalogue of incunabula owned by both libraries.
Variation in communication and family visiting policies in intensive care within and between countries during the Covid-19 pandemic: The COVISIT inte…
2022
Background: During the COVID-19 pandemic, intensive care units (ICU) introduced restrictions to in-person family visiting to safeguard patients, healthcare personnel, and visitors. Methods: We conducted a web-based survey (March– July 2021) investigating ICU visiting practices before the pandemic, at peak COVID-19 ICU admissions, and at the time of survey response. We sought data on visiting pol icies and communication modes including use of virtual visiting (videoconferencing). Results: We obtained 667 valid responses representing ICUs in all continents. Before the pandemic, 20% (106/ 525) had unrestricted visiting hours ; 6% (30/525) did not allow in-person visiting. At peak, 84% (558/667…
2022-RA-1397-ESGO Covering all angles; a case report demonstrating why lateral port entry must be perpendicular
2022
Physical and antibacterial properties of PLA electrospun mats loaded with carvacrol and nisin
2022
Functional, biopolymeric electrospun structures for the controlled release of antimicrobial agents are gaining in-creasing interest in food packaging applications. In this study, the physical and antibacterial performances of ternary systems composed of polylactic acid (PLA) electrospun mats loaded with 20 wt% of different relative amounts of carvacrol (CRV) and a commercial nisin formulation (Nis) were assessed. Scanning electron micrographs displayed micro-scaled fibers with different diameter size distributions depending on the relative concentrations of the additives. The PLA/CRV/Nis membranes??? wettability was affected by the relative amount of CRV and Nis loaded, switching from hydro…
Use of Time-Frequency map combined with DBSCAN algorithm for separation of partial discharge pulses under DC voltage
2022
The Phase-Resolved-Partial-Discharge pattern (PRPD) is a conventional technique used for the evaluation of partial discharges (PD) phenomena in High-Voltage-Alternating-Current (HVAC) systems. This map is constructed by plotting the peak of each detected pulses as a function of the phase angle of the supply voltage. Therefore it is obvious that this technique cannot be used for the analysis of data from PD mesaurement under different supply voltage condition (DC). The aim of this paper is to evaluate the application of the Time-Frequency map (TF map) for the analysis of a dataset obtained from PD measurement under DC voltage. A density-based clustering algorithm was also used to gain more i…
The dark side of foetal bovine serum in extracellular vesicle studies
2022
Extracellular vesicles (EVs) have been shown to be involved in cell-cell communication and to take part in both physiological and pathological processes. Thanks to their exclusive cargo, which includes proteins, lipids, and nucleic acids from the originating cells, they are gaining interest as potential biomarkers of disease. In recent years, their appealing features have been fascinating researchers from all over the world, thus increasing the number of in vitro studies focused on EV release, content, and biological activities. Cultured cell lines are the most-used source of EVs; however, the EVs released in cell cultures are influenced by the cell culture conditions, such as the use of fo…
Sustainability Perspectives in Organizational and Workplace Learning Studies
2022
The association between sustainability and learning in organizations and workplaces represents a current articulated grand challenge for human resource development (HRD) and learning studies and practice, which calls for integrated inquiries. However, studies of learning in organizations and workplaces deal with sustainability in scattered and diverse ways that promote calls for more integrated understandings of the different approaches and associations. This article outlines the results from a scoping thematic review mapping out leading perspectives within the research fields of HRD, organizational learning (OL) and workplace learning (WPL). This article thus explores the perspectives that…
The Abundance of Tumor-Infiltrating CD8+ Tissue Resident Memory T Lymphocytes Correlates with Patient Survival in Glioblastoma
2022
Glial tumors alone account for 40% of all CNS tumors and present a low survival rate. The tumor microenvironment is a critical regulator of tumor progression and therapeutic effectiveness in glioma. Growing evidence from numerous studies of human solid tumor-infiltrating CD8(+) T cells indicates that tissue-resident memory T cells (TRM) represent a substantial subpopulation of tumor-infiltrating lymphocytes (TILs). Although it is reported that some types of cancer patients with high immune infiltration tend to have better outcomes than patients with low immune infiltration, it seems this does not happen in gliomas. This study aimed to characterize TRMs cells in the glioma tumor microenviron…
Enhanced Current Loop PI Controllers with Adaptive Feed-Forward Neural Network via Estimation of Grid Impedance: Application to Three-Phase Grid-Tied…
2022
This paper describes a single-stage grid-connected three-phase photovoltaic inverter feeding power to the grid. Using the Recursive Least Squares (RLS) Estimator, an online grid impedance technique is proposed in the stationary reference frame. The method iteratively estimates the grid resistance and inductance values and is effective in detecting inverter islanding according to IEEE standard 929-2000. An Adaptive Feedforward Neural (AFN) Controller has also been developed using the inverse of the system to improve the performance of the inner-loop Proportional-Integral controllers under dynamical conditions and provide better DC link voltage stability. The neural network weights are comput…
Evidence for past interaction with an asymmetric circumstellar shell in the young SNR Cassiopeia A
2022
Observations of the SNR Cassiopeia A (Cas A) show asymmetries in the reverse shock that cannot be explained by models describing a remnant expanding through a spherically symmetric wind of the progenitor star. We investigate whether a past interaction of Cas A with an asymmetric circumstellar shell can account for the observed asymmetries. We performed 3D MHD simulations that describe the remnant evolution from the SN to its interaction with a circumstellar shell. The initial conditions are provided by a 3D neutrino-driven SN model whose morphology resembles Cas A. We explored the parameter space of the shell, searching for a set of parameters able to produce reverse shock asymmetries at th…