showing 36 of ~574560 from 574555 documents
The Abundance of Tumor-Infiltrating CD8+ Tissue Resident Memory T Lymphocytes Correlates with Patient Survival in Glioblastoma
2022
Glial tumors alone account for 40% of all CNS tumors and present a low survival rate. The tumor microenvironment is a critical regulator of tumor progression and therapeutic effectiveness in glioma. Growing evidence from numerous studies of human solid tumor-infiltrating CD8(+) T cells indicates that tissue-resident memory T cells (TRM) represent a substantial subpopulation of tumor-infiltrating lymphocytes (TILs). Although it is reported that some types of cancer patients with high immune infiltration tend to have better outcomes than patients with low immune infiltration, it seems this does not happen in gliomas. This study aimed to characterize TRMs cells in the glioma tumor microenviron…
Guidelines of the Italian societies of gastroenterology on the diagnosis and management of coeliac disease and dermatitis herpetiformis
2022
Introduction: Coeliac disease and dermatitis herpetiformis are immune-mediated diseases triggered by the consumption of gluten in genetically predisposed individuals. These guidelines were developed to provide general practitioners, paediatricians, gastroenterologists, and other clinicians with an overview on the diagnosis, management and follow-up of coeliac patients and those with dermatitis herpetiformis.Methods: Guidelines were developed by the Italian Societies of Gastroenterology. Following a systematic literature review, the Grading of Recommendations Assessment, Development and Evaluation methodol-ogy was used to assess the certainty of the evidence. Statements and recommendations w…
Association of Arthroscopically-Assisted Latissimus Dorsi Tendon Transfer with Implantation of a Subacromial Balloon Spacer for Patients with Irrepar…
2022
Purpose. Massive irreparable posterosuperior rotator cuff tears in an active population, resulting in a pseudo-paralytic shoulder, pose a challenge for the orthopaedic surgeon. In an effort to avoid or delay arthroplasty surgery, other surgical strategies such as arthroscopically-assisted latissimus dorsi transfer (aLDT) or the implantation of a subacromial spacer (SAS) can be considered. The aim of the present study is to associate, for the first time, these two surgical procedures in order to demonstrate the surgical feasibility and the effectiveness of their synergistic biomechanical effect. Methods. The study group consisted of patients who underwent aLDT for a massive irreparable poste…
R E L A Z I O N I T R A I N D I C E D I R E S I S T E N Z A I N T R A PA R E N C H I M A L E R E N A L E E D E N S I TA’ VA S C O L A R E R E T I N …
2022
Effects of osteopathic manipulative treatment of the pivots on lower limb function in young professional football players
2022
Introduction: The most frequent injuries in professional soccer players are those pertinent to the lower limbs. In particular, strains of the hamstrings and ligamentous injuries of the knee. Therefore, preventive measures are aimed to reduce such events. We aimed to investigate if an osteopathic manipulative treatment (OMT) of the pivots could improve lower limb function in young professional football players. Methods: Thirty-eight young male professional football players were recruited (mean age 17.8 +/- 0.44 years). These were randomly assigned to an OMT or control group (n 1/4 20 and 18, respectively). Both groups underwent osteopathic evaluation. A sit-and-reach test, a vertical jump te…
Effect of spatial distribution of impurity ions on the signal of ‘C/O monitor for Wendelstein 7-X’ - an indicator of plasma wall interactions
2022
The ‘C/O monitor’ is a dedicated diagnostic system designed to monitor light impurities (B, C, N and O) in the Wendelstein 7-X (W7-X) stellarator. Its main goal is to provide fast (∼1 ms) information about the impurity level which is measured from a large plasma volume (high throughput). Its first subsystem dedicated to measure Lyman-α lines of H-like carbon (C5+ − 3.4 nm – used as PFC material) and oxygen (O7+ − 1.9 nm – common impurity absorbed by inner vessels’ walls) is going to be commissioned during the next Operational Phase of W7-X. Since the radiated photon intensity of a given impurity depends strongly on plasma kinetic parameters (Te, ne) and impurity transport, it is important t…
La Sulla fresca o disidratata migliora le proprietà salutistiche dei formaggi ovini
2022
Nel settore dell’alimentazione dei ruminanti si registra un crescente interesse verso l’uso dei polifenoli per i diversi vantaggi che ne conseguono, fra i quali, l’ottimizzazione delle fermentazioni ruminali, con conseguente riduzione della metanogenesi e mitigazione delle emissioni di metano nell'ambiente; la riduzione della degradazione delle proteine alimentari nel rumine, favorendo quindi una maggiore disponibilità di aminoacidi per l'assorbimento intestinale e la riduzione delle escrezioni di azoto nell'ambiente; la protezione degli acidi grassi polinsaturi (PUFA) dalla bioidrogenazione del rumine, e il loro successivo trasferimento nei prodotti lattiero caseari e nelle carni che così …
Is more competition better? Retail electricity prices and switching rates in the European Union.
2022
The European Union (EU) promotes the liberalization of retail electricity markets to achieve lower prices, diversified offers, greater customer participation, and sustainable consumption behaviours. While retail competition has been a reality in most EU member states, most studies find that retail competition is suitable for large customers, but the evidence on small customers is inconclusive. We analyze data on electricity prices and switching rates in 27 EU member states and the UK from 2000 to 2019. We find that retail competition is associated with lower prices and that the effect of full liberalization is greater than that of partial liberalization.
La regina Elisabetta II (1926 – 2022)
2022
L'articolo ricostruisce la recente storia del Regno Unito e le caratteristiche salienti del common law attraverso la figura della Regina Elisabetta II
Lowered nutritional quality of prey decrease the growth and biomolecule content of rainbow trout fry
2022
Diet quality is crucial for the development of offspring. Here, we examined how the nutritional quality of prey affects somatic growth and the lipid, carbohydrate, protein, amino acid, and polyunsaturated fatty acid content of rainbow trout (Oncorhynchus mykiss) fry using a three-trophic-level experimental setup. Diets differed especially in their content of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which are physiologically essential polyunsaturated fatty acids for a fish fry. Trout were fed with an artificial diet (fish feed, DHA-rich), marine zooplankton diet (krill/Mysis, DHA-rich), or freshwater zooplankton diet (Daphnia, Cladocera, DHA-deficient). The Daphnia were gr…
α-casein micelles-membranes interaction: Flower-like lipid protein coaggregates formation
2022
Background: Environmental conditions regulate the association/aggregation states of proteins and their action in cellular compartments. Analysing protein behaviour in presence of lipid membranes is fundamental for the comprehension of many functional and dysfunctional processes. Here, we present an experimental study on the interaction between model membranes and α-casein. α-casein is the major component of milk proteins and it is recognised to play a key role in performing biological functions. The conformational properties of this protein and its capability to form supramolecular structures, like micelles or irreversible aggregates, are key effectors in functional and pathological effects…
Global impact of the COVID-19 pandemic on subarachnoid haemorrhage hospitalisations, aneurysm treatment and in-hospital mortality: 1-year follow-up.
2022
BackgroundPrior studies indicated a decrease in the incidences of aneurysmal subarachnoid haemorrhage (aSAH) during the early stages of the COVID-19 pandemic. We evaluated differences in the incidence, severity of aSAH presentation, and ruptured aneurysm treatment modality during the first year of the COVID-19 pandemic compared with the preceding year.MethodsWe conducted a cross-sectional study including 49 countries and 187 centres. We recorded volumes for COVID-19 hospitalisations, aSAH hospitalisations, Hunt-Hess grade, coiling, clipping and aSAH in-hospital mortality. Diagnoses were identified by International Classification of Diseases, 10th Revision, codes or stroke databases from Jan…
The Trasversale Sicula. Themes and action research projects in sensitive Mediterranean areas
2022
There are many sensitive territories located in disadvantaged areas of the Mediterranean where depopulation has been a significant consequence of their economic and demographic decline. This has led to the gradual flight of young people and the disappearance of certain essential services. The conservation of resources is a topic of growing interest in Europe. It is necessary to rethink a new vision concerning the territory of small towns. Within this framework, this action research project aims to define a new collective sensibility, full of resources and history, throughout the territory of the Trasversale Sicula. The narrative of a new imaginary of the Sicilian hinterland is the foundatio…
Variation in egg size and offspring phenotype among and within seven Arctic charr morphs.
2022
Maternal effects have the potential to alter early developmental processes of offspring and contribute to adaptive diversification. Egg size is a major contributor to offspring phenotype, which can influence developmental trajectories and potential resource use. However, to what extent intraspecific variation in egg size facilitates evolution of resource polymorphism is poorly understood. We studied multiple resource morphs of Icelandic Arctic charr, ranging from an anadromous morph—with a phenotype similar to the proposed ancestral phenotype—to sympatric morphs that vary in their degree of phenotypic divergence from the ancestral anadromous morph. We characterized variation in egg size and…
Transcriptome and computational analysis assess the anti-tubulin activity of [1,2]oxazole derivatives in lymphoma
2022
Systematic literature review of interpretative positions and potential sources of resistance to change in organizations
2022
Purpose: This article addresses the main concerns of existing literature about resistance to change (RC) in organizations, namely the limited interpretative position regarding RC focusing mainly on negative aspects and excluding potential benefits, and the poor consensus or even understanding of RC sources in organizations. Design/methodology: To approach our goal, a systematic literature review will be carried out. The initial sample, obtained using reproducible search algorithms on Scopus and Web of Science, comprises 65 papers. After applying five inclusion/exclusion criteria supported by previous systematic reviews, the final sample consists of 30 papers. Findings: This article demonstr…
Pierre Bourdieu e le pratiche sociali
2022
Pierre Bourdieu (1930-2002) is considered one of the greatest sociologists of the contemporary era. A scholar of many interests, as can be seen from the number of his works, the breadth of the topics he dealt with, and the breadth of the theoretical-epistemological issues he debated with the sociological scientific community, he represents the example of a French intellectual who combines an intense research life with an equally intense presence in the public debate concerning controversial issues. Born into an underprivileged family (his father was a sharecropper later employed as a postal worker) in a small town in southern France, he trained at the École Normal Supérieure under Luis Alth…
Contabilidad del sector público: objetivos, retos y oportunidades en un entorno incierto
2022
Los objetivos de este trabajo son presentar las nuevas tendencias en Contabilidad del Sector Público, desde la perspectiva de las experiencias internacionales, con especial referencia a la situación en Europa y Latinoamérica, así como los retos que será necesario afrontar para dar respuesta a las nuevas demandas que se plantean por los diferentes grupos de interés dentro del panorama socioeconómico actual, desde la perspectiva de la transparencia y rendición de cuentas de los gobiernos. Para alcanzar estos objetivos, el trabajo se estructura en cuatro apartados o bloques, dedicados al análisis del marco general del buen gobierno y la sostenibilidad de los entes públicos, como referencia nec…
Health literacy among adolescents : summary of some key findings from ten European countries
2022
Abstract Introduction In research on disparities, the concept of health literacy (HL) as a set of competencies to promote and sustain health may help in understanding the disparities better and in addressing avoidable and unfair health disparities. The presentation will present some key findings on adolescents’ HL levels in ten European countries, and how HL mediates and moderates between various background factors and health outcomes. Methods Data consisted of cross-sectional data from Health Behaviour in School-aged Children (HBSC) study from year 2017/18 of ten European countries (Austria, Belgium (Fl), Czechia, England, Estonia, Finland, Germany, Macedonia, Poland, and Slovakia). Data (…
Colorectal cancer incidences in Lynch syndrome: a comparison of results from the prospective lynch syndrome database and the international mismatch r…
2022
Abstract Objective To compare colorectal cancer (CRC) incidences in carriers of pathogenic variants of the MMR genes in the PLSD and IMRC cohorts, of which only the former included mandatory colonoscopy surveillance for all participants. Methods CRC incidences were calculated in an intervention group comprising a cohort of confirmed carriers of pathogenic or likely pathogenic variants in mismatch repair genes (path_MMR) followed prospectively by the Prospective Lynch Syndrome Database (PLSD). All had colonoscopy surveillance, with polypectomy when polyps were identified. Comparison was made with a retrospective cohort reported by the International Mismatch Repair Consortium (IMRC). This com…
Migration history and risk of psychosis: results from the multinational EU-GEI study.
2022
The European Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI) Project was funded by grant agreement Health-F2-2010-241909 (Project EU-GEI) from the European Community’s Seventh Framework programme.
PRIME RIFLESSIONI SULLA NUOVA CONCILIAZIONE PROPOSTA DALLA CORTE DI GIUSTIZIA TRIBUTARIA
2022
Il contributo analizza l'istituto della nuova conciliazione proposta dalla corte di giustizia tributaria, previsto dall’art. 4, comma 1, lett. g), della legge n. 130 del 2022, che inserisce – nel corpo del novellato d.lgs. n. 546 del 1992 - l’art. 48-bis.1, soffermandosi in particolare sul significato dell'espressione questioni di facile e pronta soluzione.
Covid-19 in Philadelphia-negative myeloproliferative neoplasms: a GIMEMA survey on incidence, clinical management and vaccine
2022
Off-Adherence Keeping (OAK) observational study: intentional off-adherence immunomodulatory multiple sclerosis treatment
2022
Aims: To evaluate how improved treatment adherence with a lower-frequency regimen/treatment of intramuscular (IM) IFN beta-1a impacts therapeutic effectiveness in relapsing-remitting multiple sclerosis (MS) patients switching from a higher-frequency injectable regimen/treatment. Patients & methods: Italian patients with relapsing-remitting MS and prior poor adherence to high-frequency injectable treatments (n = 181) were followed for 24 months after starting IM IFN beta-1a. Results: During the study, 97.4% of patients were treatment adherent; 22.1% of patients reported a relapse. The estimated probability of remaining relapse-free after 2 years was 78%. A high dropout rate (52.5%) led t…
Behavioral and Socio-Emotional Disorders in Intellectual Giftedness: A Systematic Review
2022
AbstractThis work systematically reviewed past literature to investigate the association between intellectual giftedness and socio-emotional and/or behavioral disorders. Nineteen studies met the inclusion criteria, 17 of which have children and/or adolescents as participants, and 12 have a non-gifted control group. Socio-emotional problems, such as withdrawal, were found in 3 out of 8 studies; internalizing disorders, such as anxiety, were found in 5 out of 9; externalizing disorders, such as hyperactivity, were found in 3 out of 5. The most investigated comorbidity was attention-deficit/hyperactivity disorder. A univocal conclusion on the relationship between intellectual giftedness and so…
Use of sequentially inoculation of Saccharomyces cerevisiae and Hanseniaspora uvarum strains isolated from honey by-products to improve and stabilize…
2022
Mead is a beverage produced by alcoholic fermentation of honey-must. The starter yeasts that are commonly used for the alcoholic fermentation of honey-must are oenological Saccharomyces cerevisiae strains. The objective of the present work was, for the first time, to apply yeasts of honey by-products origin to evaluate the influences the taste-olfactory attributes of mead. For this purpose, three experimental productions were set up, which included: (i) single inoculation of S. cerevisiae; (ii) single inoculation of Hanseniaspora uvarum; (iii) sequential inoculation of H. uvarum/S. cerevisiae. Two control trials were performed, using a commercial strain of S. cerevisiae of oenological origi…
Laparoscopic spleen-preserving distal pancreatectomy with splenic vessels resection (laparoscopic Warshaw procedure)
2022
Qualitative Longitudinal Research in Health Research: A Method Study
2022
Abstract Background Qualitative longitudinal research (QLR) comprises qualitative studies, with repeated data collection, that focus on the temporality (e.g., time and change) of a phenomenon. The use of QLR is increasing in health research since many topics within health involve change (e.g., progressive illness, rehabilitation). A method study can provide an insightful understanding of the use, trends and variations within this approach. The aim of this study was to map how QLR articles within the existing health research literature are designed to capture aspects of time and/or change. Methods This method study used an adapted scoping review design. Articles were eligible if they were wr…
The regulation of efferocytosis signaling pathways and adipose tissue homeostasis in physiological conditions and obesity: Current understanding and …
2022
Obesity is associated with changes in the resolution of acute inflammation that contribute to the clinical complications. The exact mechanisms underlying unresolved inflammation in obesity are not fully understood. Adipocyte death leads to pro-inflammatory adipose tissue macrophages, stimulating additional adipocyte apoptosis. Thus, a complex and tightly regulated process to inhibit inflammation and maintain homeostasis after adipocyte apoptosis is needed to maintain health. In normal condition, a specialized phagocytic process (efferocytosis) performs this function, clearing necrotic and apoptotic cells (ACs) and controlling inflammation. For efficient and continued efferocytosis, phagocyt…
Identification of an effective chemotherapy and DNA damage response inhibitor combination for diffuse large b cell lymphoma
2022
Chemotherapy forms the backbone of treatment for Diffuse Large B Cell Lymphoma (DLBCL); however, <∼20% of tumors are chemoresistant. Inhibitors of the DNA damage response (DDR) show promise as chemosensitizers. We therefore set up an in-vitro screen to identify an optimal chemotherapy-DDR inhibitor (DDRi) combination in a panel of DLBCL cell lines.
Big Ears: The Donkey-Human Relationship in Self-Exploration and Training Courses
2022
Donkeys, due to their ethological characteristics and their symbolic value within our culture, offer the opportunity to experience a deep knowledge of oneself, to discovery one's emotions but also to develop trust in oneself and in the relationship with the 'other. This article is the English version of a previous Danish version, partly modified and enriched; it deal about how and for what reasons meaningful learning experiences are feasible in every life ages, starting from early childhood. Finally, it will focus on the effectiveness of experiences with donkeys in the training of trainers
Variable Friction Dampers (VFD) for a modulated mitigation of the seismic response of framed structures: Characteristics and design criteria
2022
In this paper a new approach for the energy dissipation is discussed based on the use of Variable Friction Dampers (VFDs). The VFD device is borrowed from braking systems mechanical engineering, able to modulate its capability of dissipation, providing a constant pure friction force coupled with an additional (variable) damping force with the increasing of the displacement. Resorting to a previous study, the characteristics and the efficiency of the “braking” system in terms of reduction of the displacements and the restoring forces is described for SDOF systems under seismic excitations and compared with the performances achievable by classic constant friction dampers (CFDs). Then, a desig…
UN ELEVATO RAPPORTO NEUTROFILI-LINFOCITI AUMENTA IL RISCHIO DI EVENTI CARDIOVASCOLARI E DI DECLINO DELLA FUNZIONE RENALE IN UNA COORTE DI PAZIENTI IP…
2022
Scopo dello studio: Numerosi studi epidemiologici hanno evidenziato come l’infiammazione cronica low-grade, stimata attraverso il rapporto neutrofili-linfociti (NLR), sia collegata ai fattori di rischio cardiovascolari tradizionali e non. Scopo del nostro studio è stato quello di indagare sul potenziale ruolo prognostico del NLR riguardo la progressione della malattia renale cronica e l’insorgenza di eventi cardiovascolari avversi in una coorte di pazienti nefropatici e ipertesi. Materiali e metodi: In questo studio retrospettivo osservazionale sono stati consecutivamente selezionati 403 pazienti i nostri ambulatori di Nefrologia e Ipertensione. Ogni paziente è stato sottoposto a esame ob…
Petrographic characterization of quartzite tools from the Palaeolithic site of San Teodoro cave (Sicily): Study on the provenance of lithic raw mater…
2022
A petrographic characterization has been used here, for the first time, in the study of lithic raw materials exploited in prehistoric Sicily. Our research interests one of the oldest archaeological sites with evidence of the early human peopling of the island (∼15kyr ago): San Teodoro Cave, in northeastern Sicily. Two geological Formations, Numidian and Monte Soro Flysch gave origin to well-rounded pebbly quartzite elements scattered in the marine terraces surrounding the cave and likely exploited as one of the sources of the raw materials for the production of lithic tools by the Epigravettian communities having settled the place. The preference for one of the two qualities of quartzite is…
Study of the implementation of SPIF as a Reshaping strategy in terms of formability and accuracy performance
2022
The adaption of circular economy strategies has become increasingly necessary in current times. Researches need to be addressed on finding alternative processes or the modification of the existing processes in order to reprocess End-of-Life (EoL) components and consequently recover both materials and their functions. This research paper focuses on the use of single point incremental forming (SPIF) process for the Reshaping of sheet metal EoL components. Uniaxial and biaxial pre-straining was performed on AA5754 sheets to imitate an end-of-life component, and SPIF operations were carried out so as to obtain reshaped components. In previous works, the authors have proven the technical feasibi…
Immaginazione
2022
The most recent discoveries deriving from the exchanges between aesthetics and neuroscience – especially those stressing the importance of the sensory-motor system in both scientific and aesthetic experience – have raised a particular attention on the subjectivity of mental processes, especially those related to the knowledge processes, and on the role of imagination. These results have, still nowadays, influence and confirmation in literature, which many scholars interested in a cognitivistic approach consider as related, if not just the same, to the ability of mankind to make tools and, thus, to make sense. An example of this reciprocal influence of neuroscience and literature is without …