6BAF

2021

Isotope Shifts of Radium Monofluoride Molecules

2021

Isotope shifts of $^{223-226,228}$Ra$^{19}$F were measured for different vibrational levels in the electronic transition $A^{2}{}{\Pi}_{1/2}\leftarrow X^{2}{}{\Sigma}^{+}$. The observed isotope shifts demonstrate the particularly high sensitivity of radium monofluoride to nuclear size effects, offering a stringent test of models describing the electronic density within the radium nucleus. Ab initio quantum chemical calculations are in excellent agreement with experimental observations. These results highlight some of the unique opportunities that short-lived molecules could offer in nuclear structure and in fundamental symmetry studies.

Water transmission properties of a sandy-loam soil estimated with Beerkan runs differing by the infiltration time criterion

2021

Abstract The Beerkan method consists of a ponded infiltration experiment from a single ring inserted a small depth into the soil. Fixed, small volumes of water are repeatedly poured into the ring to maintain a quasi-zero head on the soil surface. According to the standard Beerkan infiltration run, a new water volume is poured on the infiltration surface when the previously applied volume has completely infiltrated and the soil surface is entirely exposed to air (ta criterion). However, water could also be applied when the soil exposition to air begins (to criterion) or half the soil surface is exposed to air (tm criterion). The effect of the infiltration time criterion on determination of t…

Halbwachs lecteur de L’Éthique protestante, ou comment penser l’évolution des sociétés

2021

Maurice Halbwachs a ete un lecteur assidu de Max Weber dont il s’est efforce de faire connaitre l’œuvre au public francais, en publiant regulierement des comptes rendus de ses publications, au fur et a mesure de leurs parutions. Neanmoins, sa reception outrepasse cette simple presentation. Il a en effet entretenu un long dialogue avec la pensee de Weber sur la question de l’emergence et de l’evolution du capitalisme, laquelle croise certains de ses centres d’interets. La facon dont Halbwachs comprend et utilise le travail de Weber met en evidence un certain nombre de ses preoccupations dans des debats a l’interieur desquels s’inscrit sa reflexion dans les annees 1920-1930 : la memoire colle…

What matters to older adults? Exploring person‐centred care during and after transitions between hospital and home

2021

Aims and objectives To explore person-centred care provided to a group of older adults (65+) by understanding their experiences of care received, their participation in care and what matters to them during and after the transition process between hospital and home. Background Although facilitating person-centred care (PCC) has gained increasing importance globally over the last few decades, its practical implementation has been challenging. This has caused difficulties in determining its core elements and best practices. Person-centred care aims to deliver healthcare services based on individuals' preferences. Several approaches have been developed to better implement person-centred care pr…

Quantitative Analysis of Real-Time Infrared Thermography for the Assessment of Lumbar Sympathetic Blocks: A Preliminary Study

2021

Lumbar sympathetic blocks (LSBs) are commonly performed to treat pain ailments in the lower limbs. LSBs involve injecting local anesthetic around the nerves. The injection is guided by fluoroscopy which is sometimes considered to be insufficiently accurate. The main aim was to analyze the plantar foot skin temperature data acquired while performing LSBs in patients with complex regional pain syndrome (CRPS) affecting the lower limbs. Forty-four LSBs for treating lower limb CRPS in 13 patients were assessed. Pain medicine physicians visualized the infrared thermography (IRT) video in real time and classified the performance depending on the observed thermal changes within the first 4 min. Th…

Macroeconomic Impact of Pension System Upon Private Pension Funds Scheme. Empirical Evidence from Central and Eastern European Countries

2021

Abstract The significance of retirement savings and private pension funds increased in the latest decades and gathered important amounts of capitals. The purpose of this paper is to investigate the macroeconomic effects of pension systems from an investment perspective in five Central and Eastern European countries. The analyzing process regarding several underlying macroeconomic effects of pension systems started from the premises that there is a strong connection between the structure of pension systems, the national economy and the development of the financial sector. The econometric tests were processed and applied by using pool data regression models and the method Pooled Instrumental …

Modern pollen and non-pollen palynomorphs along an altitudinal transect in Jammu and Kashmir (Western Himalaya), India

2021

Pollen and non-pollen palynomorphs were analysed from 35 modern moss cushions collected along an altitudinal gradient (2225–2552 m a.s.l.) from the Baramulla District of Jammu and Kashmir State (Western Himalaya), India. The selected sampling altitude is at the elevation of appearance of blue pine (Pinus wallichiana) and West Himalayan spruce or morinda spruce (Picea smithiana). We used cluster analysis and principal component analysis (PCA) to reveal trends and characteristics in the modern pollen and non-pollen palynomorph composition within this zone. Tree taxa mainly correlated positively with the altitudinal gradient, i.e. tree pollen is more abundant at higher altitudes. The presence …

Cost-effectiveness analysis of patent foramen ovale closure with Amplatzer plus medical therapy compared to medical therapy in patients with a histor…

2021

Abstract Background A patent foramen ovale (PFO) is formed when the ovale foramen does not close spontaneously or re-opens leaving the right and left atrium connected. The present study was conducted to analyze the cost-effectiveness of PFO closure with Amplatzer device plus medical therapy (MT) compared to MT alone in the French reimbursement system for PFO patients with a prior history of stroke, using the RESPECT study data. Methods A multi-state Markov model was used. The analysis was conducted from a collective perspective over a 10-year time horizon with 4% discount applied for costs and health effects. The simulated population included adult patients with PFO. Sub-group analysis was …

PARALLEL 303: Phase 2 randomized study of pamiparib vs placebo as maintenance therapy in patients (pts) with inoperable locally advanced or metastati…

2021

3109 Background: A subset of gastric cancers exhibits platinum sensitivity and genomic instability that is characteristic of homologous recombination deficiency (HRD). Cells with HRD are sensitive to poly (ADP-ribose) polymerase (PARP) inhibition. PARP inhibitor maintenance therapy following platinum-based chemotherapy has been a successful treatment strategy in pts with ovarian cancer. Pamiparib is an orally administered selective PARP protein 1 and 2 (PARP1/2) inhibitor that has shown potent DNA-PARP trapping activity and crosses the blood brain barrier in preclinical studies. In early phase clinical studies (NCT02361723; NCT03333915), pamiparib showed an acceptable safety profile and pr…

Structural basis of PETISCO complex assembly during piRNA biogenesis in C. elegans

2021

AbstractPiwi-interacting RNAs (piRNAs) constitute a class of small RNAs that bind PIWI proteins and are essential to repress transposable elements in the animal germline, thereby promoting genome stability and maintaining fertility. C. elegans piRNAs (21U RNAs) are transcribed individually from minigenes as precursors that require 5’ and 3’ processing. This process depends on the PETISCO complex, consisting of four proteins: IFE-3, TOFU-6, PID-3, and ERH-2. We employ biochemical and structural biology approaches to characterize the PETISCO architecture and its interaction with RNA, together with its effector proteins TOST-1 and PID-1. These two proteins define different PETISCO functions: P…

Geochemical and Petrographic Characterization of Marine-Continental Transitional Facies Shale (Qilian Basin, China): Origin of Organic Matter Input, …

2021

This study, for the first time, investigates the source, keroger pattern, evolution degree, sedimentary environment, and evaluates the hydrocarbon generating ability of marine-continental transitional facies shale from the Ebao area of the Qilian Basin in western China. The organic-rich shales of the marine-continental transitional facies were subjected to total organic carbon (TOC), rock pyrolysis, the biomarkers and kerogen microscopy analyses. The kerogen microscopy analyses indicated that the sample from ZK001 well and ZK2002 well had a mass of vitrinite and small number of exinite, so kerogen type was mainly humic. According to vitrinite reflectance, the organic matter was in the stage…

Detection of genomic regions underlying milk production traits in Valle del Belice dairy sheep using regional heritability mapping

2021

The aim of this study was to identify genomic regions underlying milk production traits in the Valle del Belice dairy sheep using regional heritability mapping (RHM). Repeated measurements for milk yield (MY), fat percentage and yield (F% and FY) and protein percentage and yield (P% and PY), collected over a period of six years (2006-2012) on 481 Valle del Belice ewes, were used for the analysis. Animals were genotyped with the Illumina 50k SNP chip. Variance components, heritabilities, and repeatability within and across lactations were estimated, fitting parity, litter size, season of lambing, and fortnights in milk, as fixed; and additive genetic, permanent environment within and across …

The role of polymorphisms occurring in BRCA1/2 genes in determining ovarian cancer risk.

2021

e17551 Background: Ovarian cancer (OC) is the 10th tumor occurring in women, it accounts for 30% of all malignant tumor affecting female genital tract in Italy. There are several factors that contribute to OC development; in 15-25% of cases family history of breast and ovarian cancer represent the main risk factor. It is well known that pathogenic variants (PVs) occurring in BRCA1/2 genes strongly increase the risk of developing OC, ranging from 50% in BRCA1 PVs carriers to 30% in BRCA2 PVs carriers. Recently genetic polymorphism has been shown to increase cancer risk, consequently polymorphisms in BRCA1/2 genes could represent low penetrance susceptibility alleles and contribute to determ…

Musculoskeletal Pain in Gymnasts: A Retrospective Analysis on a Cohort of Professional Athletes

2021

Gymnastics athletes are exposed to a high risk of injury, but also of developing musculoskeletal pain. These data are still little investigated in the available scientific literature. An online survey was distributed to 79 professional athletes who practiced artistic and rhythmic gymnastics. The survey collected demographic and anthropometric data, information about the sport practice, the training sessions, the prevalence of musculoskeletal pain gymnastics-related, and lifestyle habits. Musculoskeletal pain had a high prevalence, involving 65 of 79 athletes (82.3%). A significant correlation was found between musculoskeletal pain and the duration of sports practice, both for general pain (…

Tear Film Surface Quality in Modern Daily Disposable Contact Lens Wear

2021

Objectives As reported previously, tear film surface quality (TFSQ) should be considered in contact lens (CL) fitting. This study followed noninvasive keratograph tear film break-up time (NIKBUT) in CL wearers for 12 months to validate its clinical utility in predicting CL performance. Methods Fifty-five subjects (M/F=17/38) aged 26±4 years were prescribed silicone hydrogel or hydrogel CLs. The study included baseline measurements without CLs; 2 visits for CL fitting and control; follow-up after 3, 6, and 12 months of CL wear; and postwear visit without CLs. Ocular Surface Disease Index (OSDI), 8-Item Contact Lens Dry Eye Questionnaire (CLDEQ-8), first and mean NIKBUT (F/M-NIKBUT), fluoresc…

Intraperitoneal chemotherapy versus adjuvant chemotherapy for treatment of colo-rectal cancer at high-risk for peritoneal carcinosis

2021

Serial circulating tumor DNA analysis to assess recurrence risk, benefit of adjuvant therapy, growth rate and early relapse detection in stage III co…

2021

3540 Background: Challenges in the postoperative management of stage III colorectal cancer include: 1) selection of high-risk patients for adjuvant chemotherapy (ACT), 2) lack of markers to assess ACT efficacy, 3) assessment of recurrence risk after ACT, and 4) lack of markers to guide treatment decisions for high-risk patients e.g. additional therapy or intensified surveillance. Circulating tumor DNA (ctDNA) is a promising marker with potential to mitigate the challenges. Here we used serial ctDNA measurements to assess the correlation between recurrence and ctDNA detection: postoperative, during and after ACT, and during surveillance; and to assess growth rates of metachronous metastases…

Post-mortem findings in vaccine-induced thrombotic thrombocytopenia

2021

Greinacher et al.1 and Schultz et al.2 were the first to independently report the main clinical and laboratory features of 11 and five respective patients from Germany, Austria and Norway who developed life-threatening thrombohemorrhagic complications 5 to 16 days after the administration of the first dose of the chimpanzee adenoviral vector vaccine ChAdOx1nCoV-19 against SARS-CoV-2 and COVID-19. Subsequently Scully et al.3 reported similar findings in 23 patients treated with the same vaccine in the United Kingdom. More recently, See et al.4 reported a case series of 12 patients from the USA with cerebral venous sinus thrombosis following the vaccination with Ad26.CoV2.S employing a human …

Re-interpreting complex atrial tachycardia maps using global atrial vectors.

2021

Activation maps of scar-related atrial tachycardias (AT) can be challenging to interpret due to difficulty in inaccurate annotation of electrograms, and an arbitrarily predefined mapping window. A novel mapping software integrating vector data and applying an algorithmic solution taking into consideration global activation pattern has been recently described (Coherent™, Biosense Webster "Investigational").We aimed to assess the investigational algorithm to determine the mechanism of AT compared with the standard algorithm.This study included patients who underwent ablation of scar-related AT using the Carto 3 and the standard activation algorithm. The mapping data were analyzed retrospectiv…

Arrêt des voies d'exécution. Sûreté réelle consentie pour garantir la dette d'un tiers et procédure collective du constituant

2021

International audience; (Com. 25 nov. 2020, n° 19-11.525, arrêt n° 774 FS-P, Sté Banque de Polynésie c/ Sté Faukura et a., D. 2021. 555, note D. Robine ; ibid. 532, point de vue R. Dammann et Keyvan Malavielle ; Rev. prat. rec. 2021. 25, chron. P. Roussel Galle et F. Reille ; RTD civ. 2021. 183, obs. C. Gijsbers)

Event generation and statistical sampling for physics with deep generative models and a density information buffer

2021

Simulating nature and in particular processes in particle physics require expensive computations and sometimes would take much longer than scientists can afford. Here, we explore ways to a solution for this problem by investigating recent advances in generative modeling and present a study for the generation of events from a physical process with deep generative models. The simulation of physical processes requires not only the production of physical events, but to also ensure that these events occur with the correct frequencies. We investigate the feasibility of learning the event generation and the frequency of occurrence with several generative machine learning models to produce events l…

Enhancing the European Cyber Threat Prevention Mechanism

2021

This research will determine how it is possible to implement the national cyber threat prevention system into the EU level Early Warning System. Decision makers have recognized that the lack of cooperation between EU member countries affects public safety at the international level. Separate operational functions and procedures between national cyber situation centers create challenges. One main problem is that the European Union does not have a common cyber ecosystem concerning intrusion detection systems for cyber threats. Also, privacy and citizens’ security as topics are set against each other. The research will comprise a new database for the ECHO Early Warning System concept.

Editorial for “Quantification of Bone Marrow Fat Fraction and Iron by MRI for Distinguishing Aplastic Anemia and Myelodysplastic Syndromes”

2021

Astronomiskās un dabas parādības aizvēsturē Ziemeļeiropā: atspoguļojums vēstures avotos un arheoloģiskajā materiālā

2021

Cilvēka dzīve aizvēsturē bija ļoti cieši saista ar dabu. Līdz ar pāreju uz ražotājsaimniecību vēlā akmens laikmeta beigās, bet īpaši sākot ar bronzas laikmetu, izveidojās ideoloģija, kurā centrālo vietu ieņēma Saule un ar to saistīto gadskārtu cikli. Solārā un lunārā simbolika plaši pārstāvēta Ziemeļeiropas, arī Latvijas arheoloģiskajā materiālā. Dabas un astronomiskās parādības minētas arī pirmajos rakstītajos avotos, bet to sekas – īpaši dabas katastrofu sekas, fiksējamas arī arheoloģiskajā materiālā.

Research data supporting 'Short hydrogen bonds enhance nonaromatic protein-related fluorescence'

2021

Raw data for experimental figures. Files contain .cif (crystallographic information file) for XRD data of the L-pyro-amm structure. .xlsx file containing spectra for absorption of L-glutamine, L-pyroglutamine and L-pyro-amm. .xlsx file contains spectra for fluorescence excitation and emission collected over 8 days for L-glutamine conversion to L-pyro-amm.

Policing language in the world of new work : the commodification of workplace communication in organizational consulting

2021

Abstract This paper examines how the shift to knowledge and innovation economy has created new sites for the commodification of language and communication in the context of organizational consulting. The data come from a consultant-led development and training program of the management teams of a Finnish educational organization. In the study, the year-long training was videotaped (45 h) and followed ethnographically. By using rhetorical discourse analysis as a method, we examine how the consultant-led training activities present the role of language and communication in changing working life. The results show how the activities factualize the transformation of work and the centrality of la…

Adjuvant nivolumab (NIVO) in resected esophageal or gastroesophageal junction cancer (EC/GEJC) following neoadjuvant chemoradiotherapy (CRT): Expande…

2021

4003 Background: In CheckMate 577 (NCT02743494), NIVO demonstrated a significant and clinically meaningful improvement in disease-free survival (DFS; primary endpoint) vs placebo (PBO) and was well tolerated in patients (pts) with resected (R0) stage II/III EC/GEJC who received neoadjuvant CRT and had residual pathologic disease. Median DFS doubled with NIVO vs PBO (22.4 vs 11.0 months; HR 0.69; 96.4% CI 0.56–0.86; P = 0.0003). Serious treatment-related adverse events (TRAEs) and TRAEs leading to discontinuation were reported for < 10% of pts with NIVO and 3% with PBO. Methods: Pts were randomized 2:1 to NIVO 240 mg or PBO Q2W for 16 weeks, followed by NIVO 480 mg or PBO Q4W. Here, we p…

Expressing perception in parallel ways. Sentential Small Clauses in German and Romance

2021

This chapter compares Pseudo-relatives (‘PRs’), a construction found in most Romance languages, with ‘Subject-wieclauses’ (‘SWs’), a German construction in which the subject of an embedded wie-clause precedes the complementizer wie (‘how’; e.g. Ich sah Maria, wie sie sang, lit. “I saw Mary, how she sung”, i.e. ‘I saw Mary singing’). We show that both constructions mainly occur with perception verbs, and that they have a very similar syntactic behaviour; e.g., they can be coordinated with adjectival or prepositional small clauses and have anaphoric tense. Furthermore, they both have a clausal nature but can modify a DP. We thus propose to extend Casalicchio’s (2016) analysis of PRs to SWs: t…

Interdiction des poursuites individuelles. Demande d'annulation d'un contrat de vente

2021

International audience; (Com. 7 oct. 2020, n° 19-14.422, arrêt n° 506 F-P+B, M. D. U. et a. c/ Sté BNP Paribas personal finance et a., D. 2020. 2006 ; Rev. sociétés 2020. 710, obs. L. C. Henry ; RTD com. 2020. 936, obs. B. Bouloc)

Five-year overall survival (OS) in COLUMBUS: A randomized phase 3 trial of encorafenib plus binimetinib versus vemurafenib or encorafenib in patients…

2021

9507 Background: Combined BRAF/MEK inhibitor therapy has demonstrated benefits on progression-free survival (PFS) and OS and is standard of care for the treatment of advanced BRAF V600-mutant melanoma. Here we report a 5-year update from the COLUMBUS trial. Methods: In Part 1 of COLUMBUS, 577 pts with advanced/metastatic BRAF V600-mutant melanoma, untreated or progressed after first-line immunotherapy, were randomized 1:1:1 to encorafenib 450 mg QD + binimetinib 45 mg BID (COMBO450), encorafenib 300 mg QD (ENCO300), or vemurafenib 960 mg BID (VEM). An updated analysis including PFS, OS, objective response rate (ORR; by blinded independent central review), and safety was conducted after min…

Real-time observation of a correlation-driven sub 3 fs charge migration in ionised adenine

2021

Sudden ionisation of a relatively large molecule can initiate a correlation-driven process dubbed charge migration, where the electron density distribution is expected to rapidly move along the molecular backbone. Capturing this few-femtosecond or attosecond charge redistribution would represent the real-time observation of electron correlation in a molecule with the enticing prospect of following the energy flow from a single excited electron to the other coupled electrons in the system. Here, we report a time-resolved study of the correlation-driven charge migration process occurring in the nucleic-acid base adenine after ionisation with a 15–35 eV attosecond pulse. We find that the produ…

SURGICAL INNOVATION IN COLON CANCER: STUDY OF ROLE OF LAPAROSCOPY IN COMPLETE MESOCOLIC EXCISION (CME) FOR RIGHT-SIDED COLON CANCER. FEASIBILITY, SAF…

2021

Impact of Nitrogen Addition on Wine Fermentation by S. cerevisiae Strains with Different Nitrogen Requirements

2021

In modern oenology, supplementation of nitrogen sources is an important strategy to prevent sluggish or stuck fermentation. The present study thoroughly determined the effect of nitrogen addition timing and nitrogen source type on fermentation kinetics and aroma production, carried out by yeast strains with low and high nitrogen requirements. The results revealed that yeast strains with different nitrogen requirements have divergent reactions to nitrogen addition. Nitrogen addition clearly shortened the fermentation duration, especially for the high-nitrogen-demanding yeast strain. Nitrogen addition at 1/3 fermentation was the most effective in terms of fermentation activity, nitrogen assim…

Health-related quality of life (HRQOL) in patients (pts) with advanced gastric cancer/gastroesophageal junction cancer (GC/GEJC) or esophageal adenoc…

2021

4066 Background: CheckMate 649 (NCT02872116) is a randomized, open label phase 3 study in first line (1L) GC/GEJC/EAC. Prespecified interim results showed statistically significant improvement in overall survival (OS) and progression-free survival (PFS) for N+C vs C in all randomized pts and pts whose tumors expressed programmed death-ligand 1 combined positive score (CPS) ≥ 5. We present interim HRQOL results for CPS ≥ 5 pts, included as exploratory in the study. Methods: HRQOL was assessed using EQ-5D-3L (EQ-5D) and Functional Assessment of Cancer Therapy–Gastric Cancer (FACT-Ga). Assessments were performed at baseline (BL), every 6 weeks during treatment, and during follow-up. Change fr…

Curcumin at Low Doses Potentiates and at High Doses Inhibits ABT-737-Induced Platelet Apoptosis

2021

Curcumin is a natural bioactive component derived from the turmeric plant Curcuma longa, which exhibits a range of beneficial activities on human cells. Previously, an inhibitory effect of curcumin on platelets was demonstrated. However, it is unknown whether this inhibitory effect is due to platelet apoptosis or procoagulant platelet formation. In this study, curcumin did not activate caspase 3-dependent apoptosis of human platelets, but rather induced the formation of procoagulant platelets. Interestingly, curcumin at low concentration (5 µM) potentiated, and at high concentration (50 µM) inhibited ABT-737-induced platelet apoptosis, which was accompanied by inhibition of ABT-737-mediated…