Secretory effect of azodisalicylate (azodisal sodium) on the short circuited mucosa of the rat ileum in vitro.

1988

Azodisalicylate (ADS) is one of the newly developed substitutes of sulphasalazine consisting of two molecules of 5-amino-salicylic acid. Azodisalicylate caused diarrhoea in some patients, apparently caused by an antiabsorptive secretagogue action of this compound. The mechanism of this was studied in the short circuited isolated mucosa of the rat ileum. Mucosal addition of ADS increased the potential difference (PD) and short circuit current (Isc) at a concentration of 1.3.10(-4) mol/l (4 mg/dl) with maximal effects at 1.3.10(-3) mol/l (40 mg/dl). Epithelial resistance was only slightly decreased at the higher concentrations of 40 and 100 mg/dl. Serosal ADS had no effect on electrical param…

Fission in238U+238U collisions below the Coulomb barrier

1988

Integral fission cross sections in the system238U+238U were measured at beam energies below the interaction barrierVC. Scattering angle dependent probabilities and integral cross sections for Coulomb fission were calculated. It is concluded that earlier observed discrepancies between measured and calculated angular distributions for the one-neutron transfer product239U cannot be explained by sequential fission. Multi-nucleon transfer induced fission is observed down to energies (0.90±0.02)×VC.

The second component of human complement: Detection of two hemolytic forms in plasma by pH Variation

1988

The second component of human complement (C2) in pseudoglobulin prepared from normal plasma eluted as a single peak at high conductivity (30 mS) and pH 4.5 from the cationic exchangers S-Sepharose or Mono S in the Fast Protein Liquid Chromatography (FPLC) System. The C2 was stable at pH 4.5 and 0 degrees C if enzyme inhibitors were used and the pH was raised to 6.0 after elution from the columns. After rechromatography on Mono S in the FPLC System at the median isoelectric point of 5.5 or pH 6.0, the C2 eluted as two distinct hemolytic forms: the first peaked at 16 mS, the second at 30 mS. The two forms of C2 did not correlate with the allotypic variant of C2 in individual, normal human pla…

Evaluation of Explosive Strength for Young and Adult Athletes

1988

Abstract The explosive strengths of young (n = 361) and adult (n = 10) male athletes were evaluated by a vertical jumping and a ball-throwing test. The young athletes ranged in age from 10 to 16 years representing seven different sports events: track and field, apparatus gymnastics, basketball, ice hockey, orienteering, skiing, and wrestling. The adult subjects were volleyball players. Weighted vertical counter-movement jumps were performed on a platform connected to an electronic unit which calculated the height of the rise of the body's center of gravity. For the stationary ball throwing test, horizontal throwing velocity was measured for balls of different masses by an electrical apparat…

Serum thyroid hormones, thyrotropin and thyroxine binding globulin during prolonged strength training.

1988

The effects of progressive strength training for 24 weeks on maximal strength and pituitary-thyroid function were studied in 21 males during the training and during the following detraining period of 12 weeks. Maximal strength increased greatly (p less than 0.001) in the first 20 weeks, followed by a plateau phase in the last 4 weeks of training. Maximal strength decreased greatly (p less than 0.001) during the detraining period. The concentrations of serum total (T4) and free thyroxine (fT4) decreased (p less than 0.05 and less than 0.01, respectively) during the training period and they rose to pretraining levels during the detraining period. During the most intense training phase (the la…

On the classification of topological 4-manifolds with finite fundamental group

1988

Lateral differences in GABA binding sites in rat brain.

1988

An asymmetric distribution of GABA binding sites was found in the cerebral cortex, hippocampus, cerebellar hemispheres, striatum, and thalamus. Higher levels of [3H]GABA binding were observed in the left-side of most brain areas and in a greater percentage of adult rats, but the opposite asymmetry was found in the thalamus. A similar left-right difference in cerebral hemispheres was also found in five day-old rats, suggesting the genetic predetermination of asymmetry.

Laser welded vascular anastomosis

1988

A comparative study was undertaken to investigate the application of a specially adapted microsurgical Neodymium Yag Laser system with a wavelength of 1,319 microns and a CO2 laser system for laser assisted microvascular end-to-end anastomosis (LAMA) of the rat femoral artery. Conventionally sutured anastomoses served as controls. Postoperative investigations included patency tests, light microscopy and tensile strength measurements. Both laser systems seem to be equally suitable for LAMA: The patency rates do not differ from those of sutured anastomoses and formation of microscopically small aneurysms occurred predominantly in control animals and only once in laser groups. The clamp time n…

Psychomotor and Motor Speed in Power Athletes Self-Administering Testosterone and Anabolic Steroids

1988

Abstract The effect of self-administered testosterone and anabolic steroids on psychomotor and motor speed were studied among five top-level power athletes. The experiment included a 26-week intensive strength training period in association with the use of exogenous hormones and a 6-week follow-up after drug withdrawal. Six athletes not using exogenous hormones served as a control group. The results indicated a similar, and in most cases insignificant, improvement (0–10%) in performance in both groups in both the simple and more complicated motor and psychomotor tests. Only in maximal vertical speed related to body weight was there more improvement in the experimental group, from 122.2 to 1…

The two particle-phonon multiplet ?h 11/2 ?f 7/2 � 3? and higher-lying four-nucleon yrast states in the doubly-odd nucleus 146 63 Eu83

1988

From in-beamγ-ray measurements we have established the high-spin states in146Eu up to 3.5 MeV excitation andIπ=(15+). The highest levels observed are formed by alignment of four nucleons, involving excitation of the144Sm core. Negative-parity states at about 2 MeV are classified asπh11/2νf7/2 × 3− octupole excitations. Quantitative analyses for the octupole multiplet members and for theν=4 states based on empirical data from neighbouring nuclei are presented.

Tissue elastance and fluid conduction in normotensive and hypertensive intracerebral mass haematomas.

1988

This is an investigation into the prognostic factors of 117 patients with spontaneous normo- and hypertensive intracerebral haematomas, supported by animal experiments. Preserved tissue elastance and fluid conduction enables the drainage of intrinsic haematoma serum into the CSF spaces in normotensive patients, who showed an increased extension of a perifocal hypodensity in the CT. Arterial hypertension decreased the possibility of fluid resolution. Our experimental studies showed that in hypertensive cases the serum remained trapped in the haematoma, which explains the small hypodense area around the haematoma in most of the hypertensive cases. If as an exception in hypertensives of perifo…

Chronic Administration of Slow-Release Nifedipine Improves Arterial Compliance in Elderly Hypertensives with Systolic Hypertension

1988

Type IV collagen and laminin in slow and fast skeletal muscle in rats--effects of age and life-time endurance training.

1988

The changes in the biochemical composition of basement membrane (BM) in slow-twitch (m. soleus, MS) and fast-twitch (m. rectus femoris, MRF) skeletal muscles of rats were studied during aging and life-time endurance training (treadmill running). The concentrations of the 7S domain of type IV collagen and of the P2 fragment of laminin were determined with radioimmunoassays in the muscles of rats aged 1, 2, 4, 10, and 24 months. The concentration of type IV collagen was higher in MS than in MRF and increased significantly with age. At older ages, the concentration tended to be higher in the MS of trained than untrained rats. The concentration of laminin was significantly higher in MRF than in…

Crystallization kinetics of LDPE/Ny6 blends

1988

The crystallization behaviour of low density polyethylene/nylon 6 blends has been investigated as a function of the composition. The melting points of the polymers are almost uninfluenced by the presence of the other homopolymers except for blends with a nylon content of 75–90%. Blends with 10% nylon content do not exhibit the crystallization peak during the cooling step probably because of the low concentration and high viscosity of the low density polyethylene matrix. The crystallinity degree of the polyethylene is independent of the composition, while some variations are shown by the polyamide. Finally the rate of nucleation is strongly affected by the composition, in particular for the …

Los gastos privados de educacion

1988

Référence interne : 88089

One-year follow-up of panic disorder. Outcome and prognostic factors.

1988

A 1-year follow-up study was carried out in 77 patients with panic attacks (panic disorder). Of these patients 43% were remitted; avoidance behaviour and chronic anxiety were more persistent than panic attacks within the 1-year period. The main predictor for features of anxiety in the follow-up was avoidance behaviour. The most prominent prognostic factor for features of depression was the history of previous depressive episodes. Female patients had a poorer outcome than male patients.

Recombinant human granulocyte-macrophage colony-stimulating factor induces secretion of autoinhibitory monokines by U-937 cells

1988

Colony-stimulating factors are required for survival proliferation, differentiation and functional activation of granulocytes, macrophages and their precursor cells. In the present report, however, we demonstrate antiproliferative activity of recombinant human (rh) granulocyte-macrophage colony-stimulating factor (GM-CSF) on monoblast cell line U-937 and provide evidence for the involvement of tumor necrosis factor alpha TNF-alpha and interleukin 1 beta (IL 1 beta) in its growth inhibitory action. GM-CSF (but not granulocyte CSF, G-CSF or macrophage CSF, M-CSF) suppressed DNA synthesis and self renewal of U-937 cells. Similarly, medium conditioned by U-937 cells in response to GM-CSF (GM-CS…

Low-lying excitations in the odd-odd nucleus154Eu

1988

The doubly odd nucleus154Eu was produced during in-beam bombardments of a154Sm target with3He and deuteron beams at 27 and 10 MeV. The resulting gamma-rays were investigated using prompt and delayed gamma-gamma-coincidence equipment. The half-life of the isomeric 2+ level was determined as 2.2±0.1 μs. The partial level scheme, including numerous previously unidentified excitations, can be divided into two separate groups of levels. The results provide evidence for the existence of a very regular ground band and two rather regularK=3 level structures, whose configurations are closely related to it. In addition, several rotational sequences built on the band heads with otherK values have been…

Applikationsverfahren und dosierungsempfehlungen zur postoperativen analgesie

1988

Die systemische Applikation von Analgetika stellt nach wie vor die haufigste Form der postoperativen Analgesie dar. Kontinuierliche Plasmaspiegel eines Analgetikums konnen weder durch intermittierende intramuskulare noch durch intermittierende intravenose Bolusinjektion garantiert werden. Ganz allgemein haben lipidlosliche Substanzen oder solche mit polarer Bindung, die rasch metabolisiert werden, einen fruhen Wirkungsbeginn; eine lange Wirkdauer ist bedingt durch geringe Fettloslichkeit, hohe Rezeptoraffinitat und niedrige Elimination. Die orale Applikation ist charakterisiert durch unsichere Resorptionsbedingungen. Ahnlichen Kriterien unterliegen sublinguale, buccale, aber auch die rektal…

Review article: Percutaneous transhepatic biliary drainage: Experience with 311 procedures

1988

Percutaneous biliary drainage was performed in 296 patients on 311 occasions using a fine-needle puncture technique. In 59%, the procedure served as postoperative decompression, and in 35% for palliation of obstruction, particularly in malignant disease. Postoperative drainage for the management of postoperative complication accounted for 2.5%. In more than 80% of the patients treated, the underlying disease was malignant obstructive jaundice. In 257 retrospectively evaluated patients the following complications were observed: cholangitis (6.6%), sepsis (3.1%), bile leakage (1.6%) with two deaths (0.7%), and subcapsular hematoma and hematoma in the hepatoduodenal ligament (1.2%). Catheter d…

Counterexamples for unique continuation

1988

Norms of harmonic projection operators on compact Lie groups

1988

In order to simplify the notation, we will assume throughout that G is connected, simply connected and semisimple. Sharp estimates for vp(z 0 when G = SU(2) have been obtained by Sogge [6], who proved that Vp(Zt) ~ d~ tl/v), where y(t) is the function which is affine on [1/2, 3/4] and on [3/4, 1] and is such that 7(1/2)=0, 7(3/4)=1/4, 7(1)=1. Two results in the literature give crucial estimates from below for vp(n) in the general case. The first estimate concernes the LP'-norm of the character X, : if ,~, is the highest weight of n and 0 is half the sum of the positive roots, then II x=llp,--> + 011-dimG/p" (1.2)

Excited state dipole moments and polarizabilities of centrosymmetric and dimeric molecules. I. Model study of a bichromophoric molecule

1988

Abstract Refractometric, dielectric and electro-optical absorption measurements are reported for 1-dimethylamino-2,6-dicyano-4-methyl-benzene (I) and 1,4-bis(4′-dimethylamino-3′,5′-dicyanophenyl)bicyclo[2.2.2]octane (II). The evaluation leads to dipole moments and polarizabilities of the ground state as well as the first dipole allowed singlet state. The experimental res excellently substantiate the method of electro-optical absorption measurements in solution. It is shown that the excited dimer wavefunctions of the bichromophoric molecule II localize by solvent induced local site perturbations.

Training program for transanal endoscopic microsurgery.

1988

Televised endoscopy and the concept of the “assisted” endoscopic operation is of great help in teaching surgical endoscopic techniques. The use of training dummies provides a new method of training manual dexterity and surgical skills in special courses or in surgical skill laboratories. We have developed a training system for transanal endoscopic microsurgery. Operations with our technique were performed on 116 patients. Like other microsurgical techniques, our method requires a special introduction and intensive training. This paper presents our multistage, video-supported training course for teaching transanal endoscopic microsurgery. The one-day training session is divided into four ste…

Grundprobleme medizinischer Ethik*

1988

The discussion on ethical problems in reproductive medicine that has been going on for quite a decade, is of an exemplary nature; it is mainly focussed on extracorporeal fertilisation, prenatal diagnosis with a view to abortion, and post partum diagnosis and treatment of genetic diseases. The fundamental problems of medical ethics in general come to the fore particularly clearly in this discussion. The following article deals with these fundamental problems, whereas a subsequent article will be concerned in greater detail with the three special disciplines I have just mentioned.

Involvement of soluble mediator(s) different from interleukin (IL)1 in the antigen-induced IL 2 receptor expression and proliferation of L3T4+ (CD4+)…

1988

Proliferation of T lymphocytes (T cells) requires the interaction of interleukin 2 (IL 2) with the high affinity form of the IL 2 receptor (IL 2R). IL 2 production as well as IL 2R expression are generally induced simultaneously in T cells by the recognition of specific antigen displayed on the surface of syngeneic antigen-presenting cells. The experiments described herein show that the expression of IL 2R has different requirements than the production of IL 2 (and other lymphokines). Stimulation of antigen-specific L3T4+ T cell lines with antigen-pulsed spleen cells (SC) treated with ultraviolet (UV) light results in efficient IL 2 production but only minimal proliferation due to reduced I…

Analysis of infilled frames using A coupled finite element and boundary element solution scheme

1988

The behaviour of infilled frames subjected to horizontal loads is analysed by an iterative numerical procedure. The stiffness of the structural system is determined with variations in geometrical and mechanical characteristics. The analysis is carried out utilizing the boundary element method (BEM) for the infill and opportunely dividing the frame into finite elements, so as to transform the mutual interactions of the two subsystems into stresses distributed along the boundary for the infill and into nodal actions for the frame. This makes it possible to take into account the separation arising between the two substructures when mutual tensile stresses are involved. At first, infills withou…

Investigations on the photoelectron conversion efficiency of NaI(Tl) counters

1988

Abstract The photoelectron conversion efficiency of NaI(Tl) detectors has been measured by counting single photoelectron pulses of the detector output pulse train on a very fast storage oscilloscope. This result is compared with those obtained by the measurement of the achievable time resolution using the first photoelectron triggering technique.

Dissimilar effects of doxorubicin and isoproterenol on morphology, H2O2 content and catalase activity in mouse heart

1988

Water-intake and conflict-behaviour after acute and chronic treatment with rolipram, a phosphodiesterase inhibitor; interaction with chlordiazepoxide

1988

Das Onkozytom der Niere

1988

The angiographic findings in ten patients with renal oncocytoma are described. Characteristic features include: absence of encasement, vascular occlusions, arterio-venous shunts and contrast lakes (8/10). Spoke-wheel arrangement of tumor vessels (8/10). Homogeneous tumour contrast during the capillary phase (7/10). Sharp demarcation from the kidney and surroundings (9/10) and a peritumoral halo (4/10). If the suspicion of an oncocytoma is raised by CT examination of a space-occupying lesion (part I), angiography should be performed to confirm the diagnosis and help in planning surgical treatment.

Effects of Middle-Term Treatment with Nifedipine on Hemodynamic Parameters and on Left Ventricular Function in Hypertensive Patients

1988

Structural study of NaNdGa4S8, a luminescent material with low-concentration quenching

1988

Abstract Single-crystal X-ray diffraction analysis and optical investigations of NaNdGa 4 S 8 show that Nd 3+ ions are essentially distributed in two of the three square antiprismatic sites of a CaGa 2 S 4 -type lattice. The NdS 8 polyhedra are isolated (minimum NdNd distance: 6.07 A) so the interactions responsible for concentration quenching of the luminescence are considerably reduced

Preliminary studies on the synthesis of alkaline-free large crystals of ZSM-5

1988

Single crystals of ZSM-5 were synthesized in three systems containing Na + -TPA, Li + -TPA, and NH 4 + -TPA, respectively. Applying a reaction mixture of the molar composition 8 TPA + 123(NH 4 ) 2 O + Al 2 O 3 + 59 SiO 2 + 2280 H 2 O, alkaline-free, homogeneous, and pure single crystals of ZSM-5 were prepared up to a length of 350 μm. The crystal size and yield were found to be dependent on the water content of the starting reaction mixture and on the type of aluminium source; for example, boehmite and aluminiumtriisopropylate.

Theoretical ab initio study of the vinylcarbene-CuO complex: application to last step of the propylene partial oxidation mechanism on Cu2O

1988

Abstract Using non-empirical pseudopotentials, we have performed a theoretical study on the last step of the propylene partial oxidation mechanism, the acrolein desorption from the catalyst surface. To represent the catalyst we have used a simplified model of a catalyst active site. We have study the C 3 H 4 CuO complex, analysing the dissociation process of the oxygenated complex from a metallic centre. The results indicate that this complex dissociates into cis - and trans -acrolein and a metal site, in a process without energetic barrier.

Advances in contrast variation for macromolecular structure determination by polarized neutron scattering and anomalous dispersion of synchrotron X-r…

1988

Contrast variation for macromolecular structure determination is usually achieved by isomorphous replacement of 1-H by 2-H (D) using small-angle neutron scattering (SANS). This is particularly easy in aqueous solvents. By adding heavy water the contrast of dissolved proteins, nucleic acids and membranes changes drastically. It is the region inaccesible to solvent molecules, which acts as a label. Measurements of the scattering intensity at three different scattering densities of a solvent yields the three basic scattering functions. The contrast dependence of the radius of gyration receives particular interest. More recently smaller labels have been used. Their dimensions are smaller than t…