Does catalase play a role in Adriamycin induced cardiotoxicity?

1980

Summary Adriamycin causes an increase of lipid peroxidation in mouse cardiac homogenates that is dependent on the concentration of the antiblastic. The same phenomenon is not observed in the hearts of mice treated with an elevated dose of Adriamycin in which, conversely, an increase of the antioxidizing enzyme catalase was noticed. The significance of these findings is discussed with relationship to the hypothesis of an enhanced free radicals formation at the basis of Adriamycin induced cardiotoxicity.

Variétés différentielles

1980

Considérons une économie X sans production comprenant m consommateurs dans laquelle l'espace des biens est représente par l'espace vectoriel \Re .Chaque consommateur possède un ensemble de consommation possible Xi C R6 , une relation de préférence ^ et une dotation initiale w^. il est l'ensemble des ressources possibles

PHOSPHORORGANISCHE VERBINDUNGEN 931

1980

Abstract Optisch aktives Ethyl-phenyl-phosphinigsaurediethylamid 1 wird in racemische literaturbekannte Verbindungen uber-gefuhrt bei der Einwirkung von HCl, HBF4, Alkoholen, Thioalkoholen, Carbonsauren, Carbonsaureestern, Carbonsaureanhydriden, Carbonsaurehalogeniden, Verbindungen mit Pl und sekundaren Phosphinen. p-Kresol, Trifluoressigsaure-p-kresylester sowie Trifluoressigsaure-s,s,s-trifluorethylester setzen sich mit optisch aktivem Ethyl-phenyl-phosphinigsaure-diethylamid 1 unter Erhaltung der Konfiguration zu den entsprechenden optisch aktiven Ethyl-phenyl-phosphingsaureestern um. Optically active ethyl-phenyl-phosphinous acid diethylamide 1 was treated with HCl, HBF4, alcohols, thio…

Parity-violating asymmetry in elastic electron-nucleus scattering due to weak neutral currents

1980

Parity-violating asymmetries are calculated for elastic scattering of electrons on nuclei of arbitrary spin and isospin. Possible dependences on nuclear-model input are shown to be weak. Elastic electron scattering at intermediate energies may become an important tool in studying the structure of hadronic weak neutral currents.

Identification of a new volatile compound in onion (Allium cepa) and leek (Allium porum) : 3,4-dimethyl-2,5-dioxo-2,5-dihydrothiophene

1980

International audience

Producer's spatial equilibrium with a fuzzy constraint

1980

The classical theory of the producer’s equilibrium rests on two sets of particularly restrictive hypotheses. First it is implicitely assumed that all inputs and outputs are located in a single place where the producer is also implanted and where the production is carried out. Next it is assumed that the producer follows a precise behaviour pattern, by this we mean that the producer has complete information concerning the conditions of hisproductive activity and he has perfect command over both the set of inputs and the set of outputs; he realises the maximum profit allowed by the technological constraint which limits his possible actions and by the given price system. The aim of this study …

3d impurities in Al: density functional results

1980

Self-consistent spin density functional calculations have been carried out for 3d transition metal impurities in aluminium. The width of the virtual level decreases as it moves away from the Fermi energy with increasing occupancy. The results are compared with recent XPS measurements.

The Influence of Acetylcholine and Choline on the Incorporation of Phosphate into Phospholipids of Etiolated Bean Hypocotyl Hooks

1980

Summary Acetylcholine influenced the radiolabelling of phospholipids in vivo in etiolated hypocotyl tissue of dwarf beans in darkness. Under aerobic conditions the specific activity of the phospholipids was decreased and under anaerobic conditions increased. The biosynthesis of phospholipids was strongly increased by the bivalent cations calcium and manganese and decreased by 2,4-dinitrophenol, anaerobiosis, atropine and ascorbic acid. Magnesium stimulated the uptake of the radioactive phosphate but not the specific activity of the phospholipids. The results are discussed in comparison with the «phospholipid-effect» of acetylcholine in animal tissues.

Analysis of the intensities of the longitudinal acoustic vibrations inn-alkanes and polyethylene

1980

Simple theoretical considerations indicate, that the integral intensity of the „longitudinal acoustic modes” (LAM) in the Raman spectrum ofn-alkanes should be independent of the chain length. The experiment in fact confirms this expectation. Using this property it becomes possible for polyethylene samples, to derive from the measured LAM-intensity the mass fraction of all-turns sequences contributing to this band. For solution crystallized samples this fraction coincides with the crystallinity, whereas in melt crystallized samples it generally turns out as smaller. The observed difference is likely to be due to the occurrence of local conformational defects (kinks, chain torsions) which int…

Effects of iontophoretic 5-hydroxytryptamine on the unitary discharge frequency of caudate nucleus neurons in the rat

1980

AbstractSummaryMicroiontophoretic application of 5-hydroxytryptamine (5-HT) on rat caudate nucleus neurons has both facilitatory and inhibitory effects on the discharge frequency of the neurons; in many cases 5-HT has a two-phase action. An analysis was made of the behaviour of facilitatory and inhibitory responses in time considering the mean firing rate variations during and after 5-HT iontophoretic release. Six types of responses have been described : A : short lasting excitation, B : long lasting excitation, C : short lasting inhibition, D : delayed-onset inhibition, E : inhibition followed by excitation, F : excitation followed by inhibition. Also no topographic localization could be m…

Specificity of deoxyribonuclease hydrolysis determined by high-performance liquid anion-exchange chromatography

1980

The Effect of Different Light Intensities on the Frequency and Size of Stomata, the Size of Cells, the Number, Size and Chlorophyll Content of Chloro…

1980

Summary Plants of Sinapis alba were cultivated under high light (60 W m -2 PhAR) and low light (6 W m -2 PhAR) conditions. High light intensity during growth increased the stomatal frequency but there were only small changes in the length of the stomatal pore. High-light leaves had more than twice as many stomata per unit area as low-light leaves. The decrease of stomatal diffusive resistance in high-light leaves is primarily caused by the increase in stomatal density. There were striking changes in stomatal frequency during the ontogeny of primary leaves. High light caused a stronger development of the assimilating mesophyll. The volume of the palisade cells increased to a much higher exte…

Ultrastructure of one Ewing's sarcoma of bone with endothelial character and a comparative review of the vessels in 27 cases of typical Ewing's sarco…

1980

An atypical variant of Ewing's sarcoma, located in the left hip of a nine-year-old girl, is discussed at optical, histochemical and electron microscopical level. The endothelial appearing cells seem to play a main role in its histogenesis. Tumoral cells of an undifferentiated blastemic nature show round nuclei and bright lucent cytoplasm, being organized in solid sheets or vascular-like profiles. Alkaline and acid phosphatases are very prominent in all tumoral cells, and some of them also show PAS positive material. Its ultrastructure demonstrates an active pinocytic capacity, cytoplasmic filaments and Weibel-Palade bodies. Simultaneously a review is performed on 27 cases of typical Ewing's…

4-Aminopyridine antagonizes the inhibitory effect of pentobarbital on acetylcholine release in the heart

1980

Effects of pentobarbital on acetylcholine (ACh) release, force of contraction and nervous conduction were studied in isolated heart preparations and in cervical vagus nerves, respectively. 4-Aminopyridine and tetracaine were used as pharmacological tools to eludicate the mode of action of pentobarbital. 1. 4-Aminopyridine (10−4 M) markedly increased the overflow of ACh from the isolated chicken heart evoked by electrical stimulation (1–50 Hz, 1 ms, 40 V) of the cervical vagus nerves. This effect of 4-aminopyridine was highest at low frequencies of stimulation (+ 226% at 1 Hz) and declined with increasing frequencies to reach a minimum augmentation of 22% at 30 Hz. 2. Pentobarbital and tetra…

Bißlageverschiebung — eine Utopie?

1980

An 82 mit funktionskieferorthopadischen Geraten erfolgreich behandelten ausgepragten Fallen derAngle Klasse II,1 wurden kephalometrische Befunde zu Beginn und am Ende der Behandlung erhoben. Die Ergebnisse sprechen dafur, das mehrere Einzelveranderungen, skelettaler und dentoalveolarer Art, in variierendem Mase zum Gesamtausgleich beitragen. Der Einzelanteil bleibt dadurch gering. Mit groser Wahrscheinlichkeit tragt auch eine nennenswerte mandibulare Reaktion zum Okklusionsausgleich bei, d. h., der Unterkiefer erfahrt eine therapeutisch induzierte, wachstumsbedingte Mesialentwicklung, die erfahrungsgemas bei unbehandelten Distalbissen nicht erwartet werden kann.

La ricerca botanica in Sicilia finalizzata ai problemi del territorio

1980

Transthoracic electrical impedance during extracorporeal hemodialysis in acute respiratory failure ("Shocked Lung syndrome").

1980

The alteration (delta Z0) of transthoracic electrical impedance (TEI) during extracorporeal hemodialysis (EHD) was investigated in two Groups of patients with acute renal and acute respiratory failure, that differed with respect to the severity of respiratory insufficiency. Group I had moderate respiratory failure (FiO2 0.31 +/- 0.10, PaO2 84 +/- 14 mmHg), and Group II had severe respiratory failure (FiO2 0.75 +/- 0.17, PaO2 77 +/- 14 mmHg). There was a significant correlation between increase in TEI (delta Z0) and decrease in body weight (delta BW) in each individual patient, but the slope of regression lines was remarkably flattened in Group II. In Group I, delta TEI was 1.9 +/- 0.9 omega…

Scattering amplitudes and integral equations for the collision of two charged composite particles

1980

Transition operators for the collision of two clusters composed of an arbitrary number of charged and neutral particles are represented as a sum of pure Coulomb and Coulomb-modified short-range operators. Sandwiching this relation between the corresponding channel states, correct two-fragment scattering amplitudes are obtained by adapting the conventional two-body screening and renormalization procedure. Furthermore, integral equations are derived for off-shell extensions of the full screened amplitudes and of the unscreened Coulomb-modified short-range amplitudes. For three particles, the final results coincide with those derived previously in a different approach. The proposed theory is v…

Evidence of the same multiparticle production mechanism in p−p collisions as in e+e− annihilation

1980

The split-field magnet spectrometer at the CERN intersecting storage rings was used to measure, in p-p collisions at square root s=62 GeV, the inclusive momentum distribution of the charged particles produced in the same hemisphere as the leading proton (x>0.4). A new scaling variable was introduced in order to take into account baryon-number conservation effects in p-p interactions. It is shown that distributions in this variable are in good agreement with the momentum distribution of the hadrons produced in e/sup +/e/sup -/ annihilation. The results suggest that the multiparticle production mechanism in p-p collisions is the same as in e/sup +/e/sup -/ provided that the effects of baryon-…

Specificity of mouse liver cytosolic epoxide hydrolase for K-region epoxides derived from polycyclic aromatic hydrocarbons

1980

Mouse liver cytosol epoxide hydrolase, known to be very active for certain alkene oxides, had a specific activity which was 2.1-, 11- and 160-fold lower than that of the microsomal epoxide hydrolase for the arene oxides 7-methylbenz[a]anthracene 5,6-oxide, benz[a]anthracene 5,6-oxide and phenanthrene 9,10-oxide, respectively. For benzo[a]pyrene 4,5-oxide no activity (less than 10 pmol product/mg protein/min) of cytoplasmic epoxide hydrolase was detectable. The specific activity of cytoplasmic epoxide hydrolase was much lower for all K-region epoxides investigated, compared to trans-stilbene oxide used as a positive control and for which a new assay is described. It is concluded from these r…

Transient response in nonlinear region of molten polymers subjected to a sudden imposition of constant shear stress or constant electric field

1980

Experimental transient results in the nonlinear region are reported for a commercial polyisobutylene subjected to sudden imposition of either a constant shear stress or a constant electric field. Some steady-state results, eventually obtained in different types of experiments, are also considered. In both cases, a model analysis is presented that accounts for the nonlinear effects through changes in the free volume depending upon the applied stress. The good comparison between theoretical predictions and experimental results seems to indicate that the phenomenological approach advanced here is very promising.

Recall of common and uncommon words from pure and mixed lists

1980

Recall of high- and low-frequency words in the conventional free recall paradigm was compared with recall of the same words when subjects were required to count backward before and after the presentation of each word. The addition of this distractor task was associated with a reduction in the high-frequency advantage otherwise found with pure lists containing only high- or low-frequency words. This finding is attributed to the disruption of organizational processes. In contrast, the low-frequency advantage found with conventional presentation of mixed lists, containing high- and low-frequency words, was not reduced by distraction. These findings indicate that the frequency effects obtained …

Inhibition of Granulocyte Function by Prednisolone and Non-Steroid Anti-Inflammatory Drugs. Quantitative Evaluation with NBT Test and its Correlation…

1980

The effect of prednisolone and non-steroid anti-inflammatory drugs on PMNL (polymorphonuclear leucocytes) oxidative metabolism was quantified with a newly standardized NBT test, and it was investigated whether these effects correlate with phagocytosing capacity of PMNL. Prednisolone inhibits NBT reduction in dose dependency already at concentrations, which do not interfere with phagocytosis. Thus prednisolone dissociates phagocytosis and phagocytosis-associated oxidative metabolism. High doses of prednisolone also inhibit phagocytosis. These effects of prednisolone are still demonstrable when PMNL are washed after pre-incubation with the drug. The non-steroid anti-inflammatory drugs (indome…

Effect of serum protein binding on pharmacokinetics and anticoagulant activity of phenprocoumon in rats.

1980

The relationship among serum protein binding, kinetics of elimination, distribution, and anticoagulant activity of phenprocoumon was investigated in 25 selected outbred Sprague-Dawley rats which differed in the extent of serum protein binding of this drug. In addition, the serum protein binding of phenprocoumon was altered in inbred Lewis rats by continuous treatment with tolbutamide. This drug was found to displace phenprocoumon from serum proteins without affecting its intrinsic clearance. The serum free fraction values (fs)of the selected Sprague-Dawley rats ranged from 0.0053 to 0.0145. There were positive and linear correlations between fsand the first-order elimination rate constant (…

Internal Urinary Diversion by a Percutaneous Ureteric Splint

1980

Children from broken homes: visits to the school nurse.

1980

Children from broken homes, especially females, have an increased tendency to visit the school nurse. Complaints are often ill-defined, possibly psychosomatic. These children may require additional medical and emotional support from the school nurse. The effect the broken home may have upon a student has important implications for the physical and emotional health of today's youth. An awareness of this finding can provide school nursing personnel valuable insight in the assessment of students who visit the school nurse.

Fine specificity and cytolytic activity of continuously growing alloreactive cytotoxic T lymphocyte clones.

1980

The role of Lyt 1+ T-cell-derived secondard CTL inducing factor allowed the cloning of alloreactive cytotoxic T lymphocytes (CTL) by the limiting dilution approach. Several monoclonal cell lines were established in vitro. The lytic activity of some of the cell lines exceeded that of CTL from bulk cultures; that is, 50% of the target cells were lysed at an effector to target cell ratio of 0.04:1. The fine specificity of individual CTL clones is discussed.

An improved system for fast, continuous chemical separations (“SISAK 2”) in nuclear spectroscopic studies

1980

Abstract An improved rapid, continuous solvent extraction system (“SISAK 2”) is described. The system is connected to a gas-jet installed at the Mainz reactor. It allows single or multistage chemical separations of liquid phases by means of specially designed centrifuges within ∼1 s per stage. The application of this system to study short-lived nuclides is exemplified for neutron-rich lanthanum and cerium isotopes produced by fission.

Evidence that C1q, a Subcomponent of the First Component of Complement, is an Fc Receptor of Peritoneal and Alveolar Macrophages

1980

Abstract Guinea pig peritoneal macrophages were cultured for 24 h in the presence of two inhibitors of the biosynthesis of collagen-like molecules such as C1q : 10 -3 M 3,4-dehydroproline or 10 -4 M 2,2′-dipyridyl. Their Fc-receptor activity was measured by rosette formation, using sheep erythrocytes (E) coated with rabbit anti-sheep IgG (EA IgG ). The Fc-receptor activity was decreased by 40 to 70% of control cultures depending on the amount of IgG on the E. The activity of a second receptor on the macrophages, mediating the binding of C3b coated E, was not altered by this treatment. Rat alveolar macrophages were depleted of their Fc-receptor activity by pronase treatment (1.5 mg/ml) in th…

Rente foncière et modèles de production

1980

L'analyse économique considère habituellement que les terres donnent naissance à des rentes différentielles parce qu'elles présentent des fertilités naturelles différentes ou parce que leurs localisations offrent des situations variables par rapport à des lieux d'attraction. Cette proposition bien connue m'amène à formuler plusieurs observations. (1). On attribue généralement l'étude de la rente de fertilité à RICARDO et celle de la rente de situation à VON THÜNEN. Cela est vrai mais incomplet, car les deux analyses sont présentes chez RICARDO (1815) comme chez VON THUNEN. Mais seul ce dernier a tiré les conséquences formelles de l'analyse de la rente de situation. Quoiqu'il en soit, cette …

Fuzzy economic spaces

1980

Traditional spatial economic analysis is limited to the description of precise spaces. To say that an economic space is precise means: (1) that this space has, or else, has not given constituent characteristics and (2) that the agents located there prefer, or else, do not prefer one possible action to another. Proposition (1) implies that an economic space is perfectly delimited and that it can be clearly partitioned into homogeneous subspaces. Proposition (2) implies that economic agents undertake exact economic calculations and optimize, under rigid constraints of resource limitation, objective functions whose arguments are clearly defined. Thus, traditional spatial economic analysis is b…

Absorbing anisotropic and gyrotropic slab between crossed polarizers in parallel light

1980

When a birefringent slab is rotated between two crossed polarizers, the four maxima and four minima of the transmitted intensity occur, as known, at every π/4 radians. If the slab is also optically active, the maxima and minima are arranged in other patterns that may be grouped according to the number of extrema met in one complete turn of the slab: four or eight. All the possible patterns are classified and each is related to some peculiarity of the complex refractive index of the slab.

Phospholipase A2 and arachidonic acid: a common link in the generation of the eosinophil chemotactic factor (ECF) from human PMN by various stimuli.

1980

An eosinophil chemotactic factor (ECF) of low molecular weight can be generated and released from human polymorphonuclear neutrophils by the calcium ionophore, phagocytosis of zymosan particles, arachidonic acid, and phospholipase A2. Since the activation of cells by the ionophore and during the phagocytic event leads to phospholipid turnover, with the subsequent generation of arachidonic acid, it is reasonable that phospholipase A2 represents the common link for ECF production. The kinetics of ECF release by phospholipase A2 is similar to the pattern observed with the various stimuli. After a rapid rise in activity a decline occurred at later times of secretion, suggesting a mechanism of i…

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1980

A powerful thyristor modulator for a microtron

1980

Abstract The circuit of a powerful modulator is illustrated and a detailed description is given of the modulator construction and in particular of the components employed. The main parameters are: length of shaped pulse 2 μs; amplitude of the output voltage 30 kV; pulse repetition frequency 50–200 Hz. The compactness of this device, its comparatively low cost and its good performance, as illustrated in the attached photographs, make it suitable for use in accelerator engineering (microtron).

Nonlinear density dependence of the positron decay rate in helium

1980

The decay rate of thermalized positrons in helium is calculated as a function of the fluid density, incorporating the multiple scattering of the positron off the atoms. The obtained nonlinearity agrees with experimental data outside the self-trapping region.