showing 36 of ~574560 from 574555 documents
Health app policy:international comparison of nine countries' approaches
2022
An abundant and growing supply of digital health applications (apps) exists in the commercial tech-sector, which can be bewildering for clinicians, patients, and payers. A growing challenge for the health care system is therefore to facilitate the identification of safe and effective apps for health care practitioners and patients to generate the most health benefit as well as guide payer coverage decisions. Nearly all developed countries are attempting to define policy frameworks to improve decision-making, patient care, and health outcomes in this context. This study compares the national policy approaches currently in development/use for health apps in nine countries. We used secondary d…
Securitización urbana en el centro histórico de Valencia: actores, dispositivos y discursos
2022
Este artículo presenta un análisis etnográfico de los procesos de securitización urbana que están teniendo lugar en un barrio del centro histórico de Valencia. Trazamos una economía política de la securitización urbana en la escala local, fijándonos en el papel desempeñado por una pluralidad de actores entre los que encontramos vecindario, movimientos urbanos, cuerpos policiales e instituciones locales. El análisis se centra en una multiplicidad de dispositivos y tácticas securitarias, desde las arquitecturas preventivas y el urbanismo punitivo hasta la policialización de la convivencia vecinal y la implementación de ordenanzas de civismo, pasando por los sistemas privados de vigilancia. No…
The elasticity of a random variable as a tool for measuring and assessing risks
2022
Elasticity is a very popular concept in economics and physics, recently exported and reinterpreted in the statistical field, where it has given form to the so-called elasticity function. This function has proved to be a very useful tool for quantifying and evaluating risks, with applications in disciplines as varied as public health and financial risk management. In this study, we consider the elasticity function in random terms, defining its probability distribution, which allows us to measure for each stochastic process the probability of finding elastic or inelastic situations (i.e., with elasticities greater or less than 1). This new tool, together with new results on the most notable p…
Somatic Interventions and Depth of Experiencing in Emotionally Focused Couple Therapy
2022
Emotionally Focused Couple Therapy (EFT), an attachment-based couple therapy, views emotion as being central to the process of therapeutic change. As affect arousal of emotion is a somatic reaction, the purpose of this study was to focus on therapists’ interventions classified as noting and commenting on clients’ somatic cue of emotional experience, such as their facial expression or posture, in relation to depth of emotional experiencing demonstrated by clients in EFT couple therapy sessions. The sample included 13 therapists, each treating one couple during a single EFT training demonstration session. We coded therapists’ interventions (i.e., commenting on one partner’s somatic cue of emo…
Carcere, popolo e punizione nella šanson russa e nei neomelodici napoletani
2022
Il genere musicale conosciuto in Russia come Šanson, una rielaborazione commerciale del folklore criminale, colpisce per la somiglianza con la canzone neomelodica napoletana, che nei testi fa spesso riferimento al mondo criminale. Questo rapporto, che in Italia è oggetto di “panico morale”, è però meno stigmatizzato in Russia, dove è forte il ricordo del contatto tra intellettuali e criminali nei lager negli anni delle grandi purghe. Una spiegazione della popolarità della canzone criminale in Russia come nell’Italia meridionale può essere ricercata nell’analisi di Michel Foucault sul passaggio dal modello punitivo a quello disciplinare, quando scompaiono le biografie criminali (che avevano …
Printable Hydrogels Based on Alginate and Halloysite Nanotubes.
2022
The design of hydrogels for the controlled release of active species is an attractive challenge. In this work, we prepared hybrid hydrogels composed of halloysite nanotubes as the inorganic component, and alginate as the organic counterpart. The reported procedure allowed us to provide the resulting materials with a peculiar wire-like shape. Both optical and scanning electron microscopy were used to characterize the morphological properties of the hydrogel wires, whose diameters were ca. 0.19 and 0.47 mm, respectively. The possibility to be exploited as drug delivery systems was carried out by loading the nanoclay with salicylic acid and by studying the release profiles. Thermogravimetric e…
Global urban environmental change drives adaptation in white clover
2022
Made available in DSpace on 2022-04-28T19:52:06Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-03-18 Urbanization transforms environments in ways that alter biological evolution. We examined whether urban environmental change drives parallel evolution by sampling 110,019 white clover plants from 6169 populations in 160 cities globally. Plants were assayed for a Mendelian antiherbivore defense that also affects tolerance to abiotic stressors. Urban-rural gradients were associated with the evolution of clines in defense in 47% of cities throughout the world. Variation in the strength of clines was explained by environmental changes in drought stress and vegetation cover that varied am…
Knowledge, Attitudes, Perceptions and Vaccination Acceptance/Hesitancy among the Community Pharmacists of Palermo’s Province, Italy: From Influenza t…
2022
In Italy, following the start of the SARS-CoV-2 vaccination campaign, community pharmacies (CPs) were recruited on a voluntary basis in order to administer COVID-19 vaccines as part of their activities. The aim of the present study was to investigate the knowledge, attitudes, and practices regarding SARS-CoV-2 infection prevention, and vaccine acceptance/hesitancy towards COVID-19 and influenza vaccinations among the community pharmacists operating in the Palermo Province. A cross-sectional study was conducted, with two different questionnaires administered before and after the conduction of the vaccination campaign against SARS-CoV-2 at the COVID-19 vaccination center of the Palermo Univer…
De la localización a la movilización. Evolución del uso electoral de Instagram en España de 2015 a 2019
2022
Este artículo analiza la evolución del uso electoral de Instagram en España, desde sus inicios como canal de comunicación política hasta su actual consolidación. Se aplica un análisis de contenido de once variables a las dimensiones formal, espacial, personal, temático-discursiva e interactiva de la actividad desarrollada en esta red social por los candidatos a la presidencia del Gobierno de España de los partidos que concurrieron con una mayor expectativa de voto a las Elecciones Generales de diciembre de 2015, junio de 2016 y abril y noviembre de 2019 (571 publicaciones). Los resultados evidencian la consolidación de Instagram como herramienta de comunicación política y el creciente inter…
Unethical Leadership: Review, Synthesis and Directions for Future Research
2022
AbstractThe academic literature on unethical leadership is witnessing an upward trend, perhaps given the magnitude of unethical conduct in organisations, which is manifested in increasing corporate fraud and scandals in the contemporary business landscape. Despite a recent increase, scholarly interest in this area has, by and large, remained scant due to the proliferation of concepts that are often and mistakenly considered interchangeable. Nevertheless, scholarly investigation in this field of inquiry has picked up the pace, which warrants a critical appraisal of the extant research on unethical leadership. To this end, the current study systematically reviews the existing body of work on …
New distributional data on Haemogregarina stepanowi (Apicomplexa) and Placobdella costata (Hirudinea) parasitising the Sicilian pond turtle Emys trin…
2022
The host-parasite system "Emys trinacris - Placobdella costata - Haemogregarina stepanowi"is known for Sicily, but scarce information is available to date about the distribution of the two parasites P. costata and H. stepanowi on the island. Therefore, an extensive sampling effort through visual census and collection and analysis of blood smears of the endemic Sicilian pond turtle E. trinacris was carried out in 46 water bodies scattered throughout mainland Sicily. Our findings revealed that the distribution of both parasites is limited to the Nebrodi area, where the infection of H. stepanowi has shown a high incidence on the local turtle populations. Our data suggest no correlation between…
Indications of polymorphism in the behaviour and morphology of burbot (Lota lota) in a European lake
2022
AbstractIn this study, polymorphism in behaviour, morphology, and stable isotope signatures of burbot from Lake Southern Konnevesi, Finland, Europe, was examined. First, local knowledge was collected on exceptional polymorphism of the spawning behaviour and morphology of burbot. These phenomena were then studied based on catch samples. Interviews and catch sample analyses suggested two morphs of burbot: one morph spawning in late February in the littoral zone and other in late March, in deep profundal, depths of about 30 m. Fish caught from the profundal zone had higher average proportional somatic body weights and wider heads than those caught from the littoral spawning sites in February. …
Synthesis of nanostructured protein–mineral-microcapsules by sonication
2022
We propose a simple and eco-friendly method for the formation of composite protein–mineral-microcapsules induced by ultrasound treatment. Protein- and nanoparticle-stabilized oil-in-water (O/W) emulsions loaded with different oils are prepared using high-intensity ultrasound. The formation of thin composite mineral proteinaceous shells is realized with various types of nanoparticles, which are pre-modified with Bovine Serum Albumin (BSA) and subsequently characterized by EDX, TGA, zeta potential measurements and Raman spectroscopy. Cryo-SEM and EDX mapping visualizations show the homogeneous distribution of the densely packed nanoparticles in the capsule shell. In contrast to the results re…
Which patients at risk of cardiovascular disease might benefit the most from inclisiran? – The expert opinion of the Polish experts. The compromise b…
2022
It is the statement of the Polish Experts on the group of patients that might benefit the most from inclisiran. We indicated the fastest way to have inclisiran available for the polish patients, with the necessary changes of the existing drug program for PCSK9 inhibitors (B-101), explaining why it is the optimal way, and why, taking into account available EBM data (the ORION program), inclisiran should be added to this program. We also present some perspective on the future necessary changes in the availability of the innovative therapies such us PCSK9 targeted therapy, what, taking into account the effectiveness of LDL-C goal achievement in Poland for very high CVD risk patients (only 17%)…
Great Minds Think Alike? Spatial Search Processes Can Be More Idiosyncratic When Guided by More Accurate Information.
2022
Existing research demonstrates that pre-decisional information sampling strategies are often stablewithin a given person while varying greatly across people. However, it remains largely unknown whatdrives these individual differences, that is, why in some circumstances we collect information moreidiosyncratically. In this brief report, we present a pre-registered online study of spatial search. Usinga novel technique that combines machine-learning dimension reduction and sequence alignment algo-rithms, we quantify the extent to which the shape and temporal properties of a search trajectory areidiosyncratic. We show that this metric increases (trajectories become more idiosyncratic) when a p…
Reference curves for pediatric endocrinology: leveraging biomarker z-scores for clinical classifications
2022
Abstract Context Hormone reference intervals in pediatric endocrinology are traditionally partitioned by age and lack the framework for benchmarking individual blood test results as normalized z-scores and plotting sequential measurements onto a chart. Reference curve modeling is applicable to endocrine variables and represents a standardized method to account for variation with gender and age. Objective We aimed to establish gender-specific biomarker reference curves for clinical use and benchmark associations between hormones, pubertal phenotype, and body mass index (BMI). Methods Using cross-sectional population sample data from 2139 healthy Norwegian children and adolescents, we analyze…
Addressing Dynamics at Catalytic Heterogeneous Interfaces with DFT-MD: Anomalous Temperature Distributions from Commonly Used Thermostats.
2022
Density functional theory-based molecular dynamics (DFT-MD) has been widely used for studying the chemistry of heterogeneous interfacial systems under operational conditions. We report frequently overlooked errors in thermostated or constant-temperature DFT-MD simulations applied to study (electro)catalytic chemistry. Our results demonstrate that commonly used thermostats such as Nose−Hoover, Berendsen, and simple velocity rescaling methods fail to provide are liable temperature description for systems considered. Instead, nonconstant temperatures and large temperature gradients within the different parts of the system are observed. The errors are not a “feature” of any particular code but …
Milk Thistle (Silybum Marianum L.) as a Novel Multipurpose Crop for Agriculture in Marginal Environments: A Review
2022
Milk thistle (Silybum marianum (L.) Gaertn.) is a versatile crop that has adapted to the broadly different soil and environmental conditions throughout all continents. To date, the fruits (“seeds”) of the plant are the only reliable source of silymarin, which, given its recognized therapeutic effects and its many present and potential uses, has led to a significant re-discovery and enhancement of the crop in recent years. Overall, although many studies have been carried out globally on the bioactivity, phytochemistry, and genetics of milk thistle, few and discontinuous research activity has been conducted on its basic agronomy as well as on the farm opportunities offered by the cultivation …
Electromagnetic moments of scandium isotopes and $N=28$ isotones in the distinctive $0f_{7/2}$ orbit
2022
The electric quadrupole moment of $^{49}$Sc was measured by collinear laser spectroscopy at CERN-ISOLDE to be $Q_{\rm s}=-0.159(8)$ $e$b, and a nearly tenfold improvement in precision was reached for the electromagnetic moments of $^{47,49}$Sc. The single-particle behavior and nucleon-nucleon correlations are investigated with the electromagnetic moments of $Z=21$ isotopes and $N=28$ isotones as valence neutrons and protons fill the distinctive $0f_{7/2}$ orbit, respectively, located between magic numbers, 20 and 28. The experimental data are interpreted with shell-model calculations using an effective interaction, and ab-initio valence-space in-medium similarity renormalization group calcu…
Exergy analysis of electrodialysis for water desalination: Influence of irreversibility sources
2022
The increasing freshwater demand is pushing the development and adoption of desalination technologies. In this framework, electrodialysis has a consolidated role in brackish water desalination, but to make it competitive with other technologies for the desalination of more concentrated solutions (e.g., seawater), the specific energy consumption should be reduced. Exergy analysis provides a useful tool for determining the contribution of each thermodynamic inefficiencies on the process efficiency and the specific energy consumption. In this regard, this paper presents an exergy analysis of the electrodialysis process. A 1-D model is used for evaluating the performance of industrial-scale sys…
The Effect of Outdoor Aeroallergens on Asthma Hospitalizations in Children in North-Western Tuscany, Italy.
2022
Few data are currently available on the effects of aeroallergens in triggering respiratory symptoms in children. To evaluate the potential effects of daily outdoor aeroallergens loads on childhood admissions, in this case-crossover study, we analyzed data from 85 children hospitalized at the University Hospital of Pisa, Italy, for asthma or asthma-like symptoms without respiratory infection, between 2010 and 2019. Data were linked to outdoor allergens, temperature, nitrogen dioxide, and relative humidity observed during the same period. A 10-grains/m3 increase in the total aeroallergen concentration was associated with an increased risk of admission at lag 0 (OR = 1.054, 95% CI: 1.011&ndash…
An inverse problem for the minimal surface equation
2022
We use the method of higher order linearization to study an inverse boundary value problem for the minimal surface equation on a Riemannian manifold $(\mathbb{R}^n,g)$, where the metric $g$ is conformally Euclidean. In particular we show that with the knowledge of Dirichlet-to-Neumann map associated to the minimal surface equation, one can determine the Taylor series of the conformal factor $c(x)$ at $x_n=0$ up to a multiplicative constant. We show this both in the full data case and in some partial data cases.
Physical activity as a protective factor for dementia and Alzheimer’s disease: systematic review, meta-analysis and quality assessment of cohort and …
2022
ObjectivePhysical activity (PA) is associated with a decreased incidence of dementia, but much of the evidence comes from short follow-ups prone to reverse causation. This meta-analysis investigates the effect of study length on the association.DesignA systematic review and meta-analysis. Pooled effect sizes, dose–response analysis and funnel plots were used to synthesise the results.Data sourcesCINAHL (last search 19 October 2021), PsycInfo, Scopus, PubMed, Web of Science (21 October 2021) and SPORTDiscus (26 October 2021).Eligibility criteriaStudies of adults with a prospective follow-up of at least 1 year, a valid cognitive measure or cohort in mid-life at baseline and an estimate of the…
Insight into the Evolving Role of PCSK9
2022
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is the last discovered member of the family of proprotein convertases (PCs), mainly synthetized in hepatic cells. This serine protease plays a pivotal role in the reduction of the number of low-density lipoprotein receptors (LDLRs) on the surface of hepatocytes, which leads to an increase in the level of cholesterol in the blood. This mechanism and the fact that gain of function (GOF) mutations in PCSK9 are responsible for causing familial hypercholesterolemia whereas loss-of-function (LOF) mutations are associated with hypocholesterolemia, prompted the invention of drugs that block PCSK9 action. The high efficiency of PCSK9 inhibitors (…
Current Rectification in Junctions with Spin-Split Superconductors
2022
Spin-split superconductors exhibit an electron-hole asymmetric spin-resolved density of states, but the symmetry is restored upon averaging over spin. On the other hand, asymmetry appears again in tunneling junctions of spin-split superconductors with a spin-polarized barrier. As demonstrated recently in both theory and experiment, this fact leads to a particularly strong thermoelectric effect in superconductor-ferromagnet structures. In this work we show another important effect stemming from the electron-hole asymmetry: current rectification. We calculate the charge current in spin-polarized tunnel junctions of a normal metal and a spin-split superconductor with ac and dc voltage bias. In…
Online Deflection Compensation of a Flexible Hydraulic Loader Crane Using Neural Networks and Pressure Feedback
2022
The deflection compensation of a hydraulically actuated loader crane is presented. Measurement data from the laboratory are used to design a neural network deflection estimator. Kinematic expressions are derived and used with the deflection estimator in a feedforward topology to compensate for the static deflection. A dynamic deflection compensator is implemented, using pressure feedback and an adaptive bandpass filter. Simulations are conducted to verify the performance of the control system. Experimental results showcase the effectiveness of both the static and dynamic deflection compensator while running closed-loop motion control, with a 90% decrease in static deflection.
Inter-organizational relationships in agri-food sector: a bibliometric review and future directions
2022
PurposeThe current competitive system, complex and rapidly changing, knowledge represents one of the main strategic resources for organizations. Agri-food organizations, traditionally characterized by low-knowledge management (KM) practices, are facing several challenges that require new knowledge to improve performance and their ability to survive. Since agri-food organizations are low-propensity R&D, they are forced into a collaborative approach and the creation of inter-organizational relationships (IORs) for knowledge transfer. The purpose of this study is to offer an overview of the academic literature on knowledge transfer within scientific institutions and agri-food organizations…
Käsityksiä yhteistoimijuudesta varhaiskasvatuksen toimintaympäristössä
2022
Kuntoutuksen ja kasvatuksen yhteistoiminnan on pitkään kuvattu olevan murrosvaiheessa, jossa yksilöasiantuntijuuteen perustuvista toimintamalleista pyritään kohti yhteistoimintaa ja lapsen arjessa tapahtuvaa kuntoutusta. Yhteistoimijuudella pyritään tuen oikea-aikaiseen tarjoamiseen lapselle siten, että siitä hyötyy koko varhaiskasvatusyhteisö. Tutkimustehtävänä oli kuvata ammattilaisten sekä lasten vanhempien käsityksiä yhteistoimijuudesta varhaiskasvatuksen yhteistoiminnassa. Aineisto kerättiin yksilöhaastatteluina (n = 10) osana kehittämishanketta varhaiskasvatusympäristössä, jossa oli pidempään toiminut yhteisöllinen puheterapeutti ja hankkeen ajan myös toimintaterapeutti. Aineisto ker…
Self-replicating subduction zone initiation by polarity reversal
2022
AbstractSubduction zones have recurrently formed on Earth. Previous studies have, however, suggested that they are unlikely to start in the interior of a pristine ocean. Instead, they seem to be more likely to form from another pre-existing subduction zone. One widely cited conceptual model to start new subduction zones is polarity reversal, resulting from the shutdown of a pre-existent subduction zone due to the arrival of a buoyant block at the trench. However, the dynamic conditions by which this process occurs remain elusive. Here, we present 3D numerical models of subduction zone initiation by polarity reversal resulting from the arrival of an oceanic plateau at the trench. Our results…
Species-specific enamel differences in hardness and abrasion resistance between the permanent incisors of cattle (Bos primigenius taurus) and the eve…
2022
Hypselodont (ever-growing) teeth of lagomorphs or rodents have higher wear rates (of a magnitude of mm/week), with compensating growth rates, compared to the non-ever-growing teeth of ungulates (with a magnitude of mm/year). Whether this is due to a fundamental difference in enamel hardness has not been investigated so far. We prepared enamel samples (n = 120 per species) from incisors of cattle (Bos primigenius taurus) and nutria (Myocastor coypus, hypselodont incisors) taken at slaughterhouses, and submitted them to indentation hardness testing. Subsequently, samples were split into 4 groups per species (n = 24 per species and group) that were assessed for abrasion susceptibility by a sta…
What causes COVID-19 vaccine hesitancy? Ignorance and the lack of bliss in the United Kingdom
2022
AbstractUnderstanding vaccine hesitancy has become increasingly important during the COVID-19 pandemic as governments around the globe have been struggling to convince portions of their populations to participate in vaccination protocols. Here we report on a nationally representative survey of the United Kingdom in which data revealed that individuals showed more willingness to take fictitious vaccines (putatively produced by the US government Medicare program and the now defunct healthcare company Theranos) than to take the Sputnik and Sinovac vaccines (developed by the Russian and Chinese governments respectively). The data indicate that the critical factor in vaccine hesitancy among the …
Physicians' Perceptions of Clinical Utility of a Digital Health Tool for Electronic Patient-Reported Outcome Monitoring in Real-Life Hematology Pract…
2022
Digital health tools are increasingly being used in cancer care and may include electronic patient-reported outcome (ePRO) monitoring systems. We examined physicians’ perceptions of usability and clinical utility of a digital health tool (GIMEMA-ALLIANCE platform) for ePRO monitoring in the real-life practice of patients with hematologic malignancies. This tool allows for the collection and assessment of ePROs with real-time graphical presentation of results to medical staff. Based on a predefined algorithm, automated alerts are sent to medical staff. Participating hematologists completed an online survey on their experience with the platform. Of the 201 patients invited to participate betw…
Catalytic Diastereo- and Enantioselective Synthesis of Tertiary Trifluoromethyl Carbinols through a Vinylogous Aldol Reaction of Alkylidenepyrazolone…
2022
A diastereo- and enantioselective organocatalytic aldol reaction between alkylidenepyrazolones and trifluoromethyl ketones leading to chiral tertiary alcohols bearing a trifluoromethyl group is presented. The methodology is based on the use of a bifunctional organocatalyst in order to activate the γ-hydrogen atoms of the alkylidenepyrazolone nucleophile and the carbonyl group of the trifluoromethylarylketone providing highly functionalized trifluoromethyl alcohols with moderate yields, excellent diastereoselectivity, and moderate to good enantioselectivity. Experiments monitoring the conversion by 1H NMR and the enantiomeric excess by HPLC with the reaction time showed that full conversion …
Paul Pasquali, Héritocratie. Les élites, les grandes écoles et les mésaventures du mérite (1870-2020) (La Découverte, 2021)
2022
Par l’originalité de son approche et de la thèse qu’il défend, Paul Pasquali apporte une contribution novatrice à la sociologie du mérite en tant que croyance institutionnalisée (voir aussi Allouch, 2021 ; Duru-Bellat, 2019). Retraçant un siècle et demi de politiques de l’enseignement supérieur français, l’ouvrage Héritocratie est précieux en ce qu’il dissipe certaines « illusions mémorielles » (p. 266) relatives au recrutement des élites et donne une épaisseur historique aux débats contempor...
Accurate automatic object 4D tracking in digital in-line holographic microscopy based on computationally rendered dark fields
2022
AbstractBuilding on Gabor seminal principle, digital in-line holographic microscopy provides efficient means for space–time investigations of large volumes of interest. Thus, it has a pivotal impact on particle tracking that is crucial in advancing various branches of science and technology, e.g., microfluidics and biophysical processes examination (cell motility, migration, interplay etc.). Well-established algorithms often rely on heavily regularized inverse problem modelling and encounter limitations in terms of tracking accuracy, hologram signal-to-noise ratio, accessible object volume, particle concentration and computational burden. This work demonstrates the DarkTrack algorithm—a new…
The chemical composition of the aerial parts essential oil of S. spreitzenhoferi Heldr. (Lamiaceae) growing in Kythira island (Greece)
2022
Stachys is a large genus of economically important plants belonging to Lamiaceae family that includes about 300 species as annual or perennial herbs. Several species of this genus are extensively used in various traditional medicines. In the present study the chemical composition of the essential oil from aerial parts of Stachys spreitzenhoferi Heldr., a very rare plant, belonging to Section Candidae, endemic of South Greece and collected in the island of Kythira, was analysed by GC-MS. No one reports have been previously published on this species. The result showed the presence of large quantity of diterpenoids with manoyl oxide (22.1%), as the most abundant component. Other metabolites pr…