Synthese von 9‐Oxabicyclo[6.1.0]non‐3‐in

1987

Ausgehend von 1,5-Cyclooctadien (1) wird in einer siebenstufigen Synthese die Titelverbindung 9 gewonnen. Sie liegt in zwei Konformationen 9a und 9b vor, wobei in 9a eine starke sterische Wechselwirkung zwischen dem Sauerstoffatom und der gespannten Dreifachbindung auftritt. Zur Einfuhrung der Dreifachbindung dient die thermische Fragmentierung des 1,2,3-Selenadiazols 7. Der Strukturnachweis fur die regiospezifische Bildung von 7 wird mit 2D-NMR-Spektroskopie gefuhrt. Starting with 1,5-cyclooctadiene (1), the title compound 9 is gained in a synthesis of seven steps. 9 exists in two conformations 9a and 9b, of which 9a shows a strong interaction between the oxygen atom and the strained tripl…

l-glutamine: a major substrate for tumor cells in vivo?

1987

From 65 human breast cancer xenografts investigated, a net glutamine uptake was found in 13 tumors (mean +/- SE: 15.7 +/- 4.5 nmol/g per min) whereas a net release (22.5 +/- 3.3 nmol/g per min) was observed in 40 tumors. In 12 tumors neither a significant net uptake nor a net release was obvious. There is experimental evidence that glutamine is taken up by cancer cells only at arterial concentrations greater than 0.5 mM. Another parameter determining glutamine utilization by tumor cells may be the tissue oxygenation. In hypoxic or anoxic tumor areas, glutamine oxidation is unlikely since oxygen is required for the reoxidation of coenzymes which are reduced in the course of this metabolic pa…

Separation of fission products by the ion guide fed isotope separator, IGISOL

1987

Abstract The performance of the ion guide method in the on-line mass separation of fission products has been investigated. Activity was produced by bombarding nat. U targets with a beam of 20 MeV protons. All the mass chains from A = 95 through A = 120 have been scanned using conventional methods of nuclear spectroscopy. No chemical selectivity in the separation was observed; isotopes of highly nonvolatile elements from yttrium to palladium were produced with efficiencies equal to those for the more volatile ones. The boundary of known neutron-rich nuclides was reached throughout the mass region from A = 106 to A = 118. During the course of this preliminary study the new isotope 116 Rh was …

The ion-guide isotope separator on-line at the Tohoku University Cyclotron

1987

Abstract The status of the ion-guide isotope separator on-line at the Tohoku University Cyclotron is reported. The optimum ion-guide parameters were determined from test experiments using atomic and molecular ions ionized with an electric discharge inside the target chamber as well as using 64 Ga(T 1 2 = 2.6 m ) ions produced by the 64Zn(p, n) reaction. Using the present system together with a ΔE−E plastic counter telescope and a germanium detector we identified 16 short-lived nuclei including the first mass-separated nuclei 57Cu and 45V. The efficiency of mass separation for 64Ga was ϵ ∼ 1%, where ϵ is defined as the number of atoms collected at the end of the separator divided by that rec…

Distribucion y formacion de rentas en Andalucia

1987

International audience

Die Karteikarte als Instrument der Behandlungsführung

1987

In der vorliegenden Studie wird uber die Erfahrungen mit einer Karteikarte berichte, die nach systematischen Uberlegungen als Instrument der Behandlungsfuhrung konstruiert wurde. Sie solte eine rasche und umfassende Vergegenwartigung eines Behandlungsfalles, d. h. der Ausgangssituation des Behandlungsplanes und des bisherigen Behandlungsverlaufs, ermoglichen und damit der besseren Uber vachung dienen.

Urothelial Leukoplakia: New Aspects of Etiology and Therapy

1987

AbstractWe describe 3 women in 1 family who had systemic urothelial leukoplakia with no underlying pathological condition of the urinary tract. Irritative clinical symptoms resolved, and the macroscopic and microscopic appearance improved after 6 months of therapy with sodium pentosan-polysulfate. Electron microscopy showed special cells in the basal layer of the cornified squamous epithelium that also have been found in the trigone of women with so-called squamous metaplasia. Their similarity to Merkel’s cells of the skin supports the theory that ectodermal cells are misplaced during embryogenesis. Genetic factors and sex hormones seem to influence the development of certain variants of sq…

“Three-level shock” in ablation-refractory paroxysmal atrial fibrillation

1987

His-bundle ablation is a very effective method to control drug-refractory supraventricular arrhythmias. We present a 69-year-old woman with paroxysmal atrial fibrillation, in whom several attempts of unipolar and bipolar His-bundle ablation were ineffective. Ultimately a stable 2/1 atrioventricular block was induced when three successive shocks of 400 W were applied. The first shock was given in that position with the largest His-potential deflection. The other two shocks were applied at catheter positions more distal and more proximal from the first one, respectively. We suppose that the initial lack of success was due to an atypical atrioventricular junction anatomy.

Coreconstitution of bacterial ATP synthase with monomeric bacteriorhodopsin into liposomes. A comparison between the efficiency of monomeric bacterio…

1987

The conditions for coreconstitution of a bacterial ATP synthase and bacteriorhodopsin into lecithin liposomes and for light driven ATP synthesis have been optimized. A rate of maximally 280 nmol ATP min-1 mg ATP synthase-1 was achieved with monomerized bacteriorhodopsin compared with a rate of up to 45 nmol ATP min-1 mg-1 found for proteoliposomes containing bacteriorhodopsin in the form of purple membrane patches. The different rates are explained by the finding that monomeric bacteriorhodopsin is more homogeneously distributed among the liposomes than the purple membrane patches. The final activities depended on both the purification method for the two proteins and the coreconstitution pr…

false

1987

Soluble and nuclear oestrogen receptor status of advanced endometrial cancer in relation to subsequent clinical prognosis

1987

Both soluble and nuclear oestrogen receptors have been measured in at least two separate sections from 72 endometrial cancers and 12 normal endometria. Concentration of oestrogen receptor is shown to be, in our hands, more meaningful when expressed per unit DNA than per unit protein, whether for soluble or nuclear receptor. Endometrial cancer cells from the central part of the tumour are shown to be receptor negative more frequently than those from peripheral tumour. Thus, in large cancers, biopsies from different areas are required before a tumour can be correctly designated as receptor positive, heterogeneous or receptor negative. The intratumoral variation of receptor status may relate t…

Presence of nucleosomes inPenicillium chrysogenum

1987

We have studied the chromatin structure ofPenicillium chrysogenum. This fungus presents the typical nucleosomal repeat and the core DNA size characteristic of all the eukaryotes. The repeat length (about 180 base pairs) is in the range of those obtained for most fungi (160–180 base pairs) and shorter than in higher eukaryotes. Knowledge aboutP. chrysogenum chromatin structure opens the way to the study of the mechanisms of genetic regulation in this filamentous fungus.

Effects of brofaremine (CGP 11 305A), a short-acting, reversible, and selective inhibitor of MAO-A on sleep, nocturnal penile tumescence and nocturna…

1987

The effects of brofaremine (CGP 11 305A), a short-acting, reversible and selective inhibitor of MAO-A, on sleep, nocturnal penile tumescence (NPT) and hormonal secretion during the night were studied during a long-term trial. Three healthy males underwent sleep-EEG and NPT recordings during consecutive nights (1) under placebo, (2) under stepwise increasing dosages of brofaremine and (3) under placebo after withdrawal. Hormone profiles were sampled during selected nights to analyze the plasma concentration of cortisol, HGH, prolactin, testosterone, LH and FSH. REM sleep was suppressed markedly under 150 mg brofaremine, while stages 1 and 2 increased. In comparison to the effect of irreversi…

Muscarinic mobilization of choline in rat brain in vivo as shown by the cerebral arterio-venous difference of choline.

1987

In anesthetized rats, the choline levels of cerebrospinal fluid and plasma obtained from blood collected from peripheral vessels (carotid artery, cardiac vessels) and from the transverse sinus were determined with a radioenzymatic assay. Cortical release of choline was studied using the "cup technique." The plasma choline level of the peripheral blood (11.5 mumol/L) was lower than that of the sinus blood. The resulting cerebral arterio-venous difference of choline was negative (3.2 mumol/L) and reflected the net release of choline from the whole brain. The plasma choline levels were not different irrespective of whether the rats were anesthetized with ether, urethane, or pentobarbital. Howe…

Significance of various enzymes in the control of reactive metabolites

1987

Most chemical carcinogens are relatively inert and need metabolic activation to the ultimately carcinogenic species. The concentration of such species is controlled by several different enzymes. Especially well studied is the important group of enzymes responsible for the control of reactive epoxides. Many natural, as well as man-made foreign compounds, including pharmaceuticals, possess olefinic or aromatic double bonds. Such compounds can be transformed to epoxides by microsomal monooxygenases present in many mammalian organs. By virtue of their electrophilic reactivity, such epoxides may spontaneously react with nucleophilic centres in the cell and thus covalently bind to DNA, RNA and pr…

Acute myocardial effects of mitoxantrone in the rabbit

1987

Some clinical studies that were performed for the purpose of assessing the potential cardiotoxicity of mitoxantrone (DHAD) have shown that repeated administrations of the drugs in some patients cause a mild impairment of cardiac functions and morphological changes in the myocardial cells qualitatively similar to those elicited by anthracyclines. Since doxorubicin has been reported to cause acute cardiac effects, probably related to its chronic cardiotoxicity, experiments were carried out on the rabbit heart to investigate whether DHAD is also able to induce acute cardiac effects. Our results show that this drug caused a reversible dose-related impairment of cardiac contractility on the isol…

Critical phenomena in polymer mixtures: Monte Carlo simulation of a lattice model

1987

A lattice model of a symmetrical binary (AB) polymer mixture is studied, modelling the polymer chains by self-avoiding walks withN A =N B =N steps on a simple cubic lattice. If a pair of nearest neighbour sites is taken by different monomersAB orBA, an energye ab is won; if the pair of sites is taken by anAA or aBB pair, an energye is won, while the energy is reduced to zero if at least one of the sites of the pair is vacant. To allow enough chain mobility, 20% of the lattice sites are vacancies. In addition to local motions of the chain segments we use a novel “grand-canonical” simulation technique:A chains are transformed intoB chains and vice versa, keeping the chemical potential differe…

Book Review: Ion Solvation. By Y. Marcus

1987

Selective Inhibition of Human Natural Killing and Antibody-Dependent Cellular Cytotoxicity by a Polyanion

1987

A high molecular polyanion, Liquoid, was found to inhibit at nontoxic concentrations (12-50 micrograms/ml) the natural killing (NK) and the antibody-dependent cellular cytotoxic (ADCC) activity of human peripheral blood mononuclear cells selectively. Whereas NK of the K 562 target cell was slightly or not at all affected, the spontaneous lysis of PDe-B-1, an EBV-transformed B-cell line, was strongly inhibited or even completely abolished. ADCC activity could only be inhibited by Liquoid if the target cells were mycoplasma-free, while the polyanion had no effect when mycoplasma-contaminated target cells were used. Liquoid did not alter the target binding capacity of the NK effector cells and…

Les jeunes filles à la sortie du lycée

1987

International audience

On a global superconvergence of the gradient of linear triangular elements

1987

Abstract We study a simple superconvergent scheme which recovers the gradient when solving a second-order elliptic problem in the plane by the usual linear elements. The recovered gradient globally approximates the true gradient even by one order of accuracy higher in the L 2 -norm than the piecewise constant gradient of the Ritz—Galerkin solution. A superconvergent approximation to the boundary flux is presented as well.

Precise ground-state hyperfine splitting inii173

1987

A laser-microwave double-resonance experiment on electrodynamically trapped $^{173}\mathrm{Yb}^{+}$ ions has been performed and a value of \ensuremath{\Delta}${\ensuremath{\nu}}_{\mathrm{h}\mathrm{f}\mathrm{s}=10\phantom{\rule{0ex}{0ex}}491\phantom{\rule{0ex}{0ex}}720239.55}$\ifmmode\pm\else\textpm\fi{}0.09 Hz for the ground-state hyperfine separation has been determined. This value is corrected for small Zeeman and second-order Doppler shifts. Combined with a previous similar measurement on $^{171}\mathrm{Yb}^{+}$ and with the known ${g}_{I}$ values of both isotopes, we obtain a value of -0.004 25(6) for the differential hyperfine anomaly $^{171}\mathrm{\ensuremath{\Delta}}^{173}$.

Automated DNA-image cytometry: a prognostic tool in infiltrating bladder carcinoma?

1987

In a retrospective study, paraffin-embedded cystectomy specimens obtained from 46 patients with bladder cancer (stage pT1 — pT4a, pN0, pN2) were analysed for tumor DNA ploidy and proliferation using automated image cytometry (LEYTAS). In 41 cases, DNA ploidy could be measured. Estimation of proliferation was possible in 26 tumors. The number of cells with a DNA content higher than 5C could be calculated in 38 of the tumors. All these three parameters are shown to correlate with patient outcome.

Expression and inducibility of drug-metabolizing enzymes in preneoplastic and neoplastic lesions of rat liver during nitrosamine-induced hepatocarcin…

1987

The expression, inducibility, and regulation of four different cytochrome (cyt.) P-450 isoenzymes (PB1, PB2, MC1, and MC2) NADPH-cytochrome P-450 reductase, the glutathione transferases (GSTs) B and C and microsomal epoxide hydrolase (mEHb) have been studied during nitrosamine-induced hepatocarcinogenesis using immunohistochemical techniques. The investigations revealed basic differences in the expression of the individual drug metabolizing enzymes in the course of neoplastic development. While the two GSTs and mEHb were increased in all preneoplastic and benign neoplastic lesions, the levels of the distinct cyt. P-450 isoenzymes were characteristically different from each other. Following …

Synthesis and characterization of the acetazolamide complexes of Co(II) and Zn(II)

1987

Abstract The preparation and characterization of the complexes of Acetazolamide (Acm) with Co(II) and Zn(II) are described. The complexes are of the type M(Acm) 2 (NH 3 ) 2 . Monodentate or bidentate behaviour of Acm from the electronic properties and the IR spectral data is discussed. The probable structures of the complexes are proposed.

Different coping patterns in the families of aphasic people

1987

Abstract Changes occurring in families as a result of aphasia are important to study as part of the rehabilitation process. It has been shown that the most common attitude in the families of aphasic people seems to be overprotection which increases mutual dependence between spouses (Biorn-Hansen 1957, Malone, Ptacek and Malone 1970, Kinsella and Duffy 1980). It has been suggested that behind this overprotective attitude are. perhaps, latent guilt feelings or prevalent problems and anxiety (Borden 1%2. Overs and Belknap 1967, Buck 1968. Mykyta, Bowling, Nelson and Lloyd 1976). Generalizations about coping mechanisms offamilies are difficult to make especially from small regional samples or, …

Stages in the compaction of peat; examples from the Stephanian and Permian of the Massif Central, France

1987

Thick coal seams in the intramontane basins of the Massif Central allow a detailed study of peat/coal compaction. Three stages of compaction can be detected. Stage 1—occurred during the deposition of the peat. Coal beds which thicken and dip away from penecontemporaneous sandstones suggest rapid compaction. Stage 2—compaction of peat related to overburden pressure in some cases resulted in the formation of lakes over peat beds. The thickness of the lacustrine deposits may give an indication of the amount of compaction that took place. One possibility is that the early compaction was related to the progradation of siliciclastics over the peat. Stage 3—occurred after the organic sediment achi…

Effects of temperature on the acute toxicity of heavy metals (Cr, Cd, and Hg) to the freshwater crayfish, Procambarus clarkii (Girard).

1987

Chromium, an essential trace element for humans and animals is involved in normal carbohydrate metabolism; however, it is toxic at high concentrations. There is no evidence that cadmium and mercury are biologically essential but their toxicity for organisms is well known. Both cause toxic effects at low concentrations to most organisms, especially in combination with other environmental variables such as temperature. Lake Albufera and the surrounding rice field waters are subjected to very heavy loads of sewage and toxic industrial residues (including heavy metals) from the many urban and waste waters in this area. In 1978, the American red crayfish Procambarus clarkii appeared in lake Albu…

Optical spectroscopy using mass-separated beams: Nuclear properties of unstable indium and tin isotopes

1987

Abstract Collinear fast-beam laser-spectroscopy has been used to measure the hyperfine structure and isotope shift of several indium and tin isotopes. The related experimental techniques are described, including the preparation of mass-separated beams of neutron-deficient indium and tin isotopes at the GSI on-line mass separator following fusion-evaporation reactions. The deviation of the observed dependence of the charge radii upon the neutron number from the expected behaviour is briefly discussed.

Anti-glomerular basement membrane antibody-mediated glomerulonephritis due to glue sniffing

1987

A 16-year-old girl developed rapidly progressive glomerulonephritis and renal failure. The disease was associated with high titres of antiglomerular basement membrane antibodies in serum, linear deposits of immunoglobulin G and diffuse epithelial crescents on renal biopsy. Past history revealed heavy smoking and deliberate sniffing of Pattex glue, a mixture of hydrocarbons which possibly may affect the structure of glomerular basement membrane. After treatment by repeated plasmapheresis and drug immunosuppression autoantibodies disappeared from serum but renal function was not influenced. Renal damage is a potential hazard for glue sniffing adolescents.

Characteristics of lysosomal phosphomannosyl-enzyme receptors in the rat heart

1987

The receptor system recognizing mannose 6-phosphate groups of lysosomal enzymes has been characterized, e.g. in fibroblasts and liver cells. The purpose of this study was to demonstrate the presence of a phosphomannosyl receptor system in rat heart muscle. The characterization of receptors was accomplished with beta-N-acetylglucosaminidase (beta-GA) secreted by rat embryo fibroblasts after ammonium chloride stimulation. The receptor binding of ligand enzymes was saturated by adding increasing concentrations of beta-GA and the binding increased linearly when the content of membrane protein was increased. The binding of beta-GA was inhibited by mannose and glucose phosphates, especially manno…

ROUTES OF HIV-2 TRANSMISSION IN WESTERN EUROPE

1987

Enthalpies of solution and dilution of butanol and pentanol in dodecyltrimethylammonium bromide micellar solutions

1987

The enthalpies of solution and of dilution of 1-butanol and 1-pentanol were measured in micellar solutions of dodecyltrimethylammonium bromide by systematically changing the concentration of alcohols and surfactant. The enthalpies of solution at infinite dilution of alcohols at each surfactant concentration were evaluated from a linear plot. This quantity increases with surfactant concentration (up to 0.8m) with a curvature which depends on the alcohol alkyl chain length. The difficulties arising for a quantitative treatment of both the enthalpies of dilution and of solution at finite alcohol concentrations are discussed. The dependence on the surfactant concentration of the standard enthal…

Characterization By Electroreflectance Of Thin Films And Thin Film Interfaces In Layered Structures.

1987

This paper reports investigations of ZnS quasi-amorphous films by electroreflectance (ER). The films were produced by thermal evaporation and their structure determined by electron diffraction. A voltage Vo cos cut was applied through the film with two evaporated Al electrodes. A lock-in amplifier gave 2 signals, Sf at f=ω/2π frequency and S2f at 2f frequency. The S2f spectrum, characteristic of the centrosymmetric bulk component of the film, reveals tails of localized states typical of amorphous semi-conductors. The Sf spectrum, characteristic of the interface layers with broken centro-symmetry, reveals tails of impurity levels which we attributed to diffusion of the electrode metal into t…

Defect recovery in aluminum irradiated with protons at 20 K.

1987

Aluminum single crystals have been irradiated with 7.0-MeV protons at 20 K. The irradiation damage and its recovery are studied with positron-lifetime spectroscopy between 20 and 500 K. Stage-I recovery is observed at 40 K. At 240 K, loss of freely migrating vacancies is observed. Hydrogen in vacancies is found to stabilize the vacancies and prolong stage III to above 280 K, where the hydrogen bound to vacancies is released. Single and multiple occupancy of hydrogen atoms at monovacancies is put forward as the reason for the two recovery stages between 280 and 400 K. A binding energy of 0.53 +- 0.03 eV is found for a hydrogen atom trapped at a monovacancy. The results are in excellent agree…

Immunocytochemical study of an endometrial diffuse clear cell stromal sarcoma and other endometrial stromal sarcomas

1987

Intermediate filament composition was studied in the following endometrial stromal tumors: low-grade stromal sarcoma (endolymphatic stromal myosis), high-grade stromal sarcoma with an associated adenocarcinoma (collision tumor), diffuse clear cell stromal sarcoma and a mesodermal mixed tumor (carcinosarcoma). The tumor cells of the stromal tumors as well as the mesenchymal elements of the mixed mesodermal tumor were decorated exclusively with antibodies to vimentin. Desmin was not demonstrated in these tumor cells. A biochemical study of the cytoskeletal filaments present in the low-grade stromal sarcoma revealed, in addition to vimentin, beta and gamma actin as seen in normal endometrial s…