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La recherche universitaire : analyse du coût dans une trentaine de formations de recherche à l'université de Dijon
1975
référence interne : 75008
Purification of rat liver epoxide hydratase to apparent homogeneity.
1975
Epoxide hydratase (EC 4.2.1.63) is a microsomal enzyme which catalyses the conversion of epoxides to trans-dihydrodiols. Epoxides, produced by the action of microsomal monooxygenases (EC 1.14.1.1) from aromatic and olefinic compounds, are thought to be responsible for many of the harinful effects of polycyclic hydrocarbons and related compounds. Thus epoxide hydratase, together with glutathione 9transferases, (EC 2.5.1.18) may play an important role in the removal of carcinogenic and cytotoxic metabolites (for reviews see [l-3]). It has been reported [4,5] that dihydrodiols formed from some polycyclic hydrocarbons (benz(a)anthracene and benzo(a)pyrene) are reactivated by the microsomal mono…
Properties and amino acid composition of pure epoxide hydratase
1975
1. Introduction Rat liver epoxide hydratase [EC 4.2.1.631 which catalyses the conversion of epoxides to trurans-dihydro- diols has been purified to apparent homogeneity as determined by three independent criteria [l] . The preparation obtained was capable of catalysing the hydration of both styrene oxide and the 4,5- (K- region)epoxide of benzo(a)pyrene [ 11. Epoxides of polycyclic hydrocarbons have been implicated as the agents responsible for the cytotoxic and carcinogenic properties of such compounds (for reviews see [2-41). A detailed knowledge of the properties of epoxide hydratase may, therefore, contribute towards an understanding of the mechanisms of cytotoxicity and carcinogenesis.…
Epoxides metabolically produced from some known carcinogens and from some clinically used drugs. I. Differences in mutagenicity.
1975
The epoxide metabolites of two clinically used drugs and an experimental psychotropic agent, carbamazepine 10,11-oxide, cyproheptadine 10,11-oxide and cyclobenzaprine 10,11-oxide, were fully devoid of any mutagenic activity under conditions where K-region-epoxide metabolites of some known carcinogens, such as benzo (a)pyrene, proved to be potent frameshift mutational agents for Salmonella typhimurium TA 1537 and TA 1538. All epoxides tested were non-mutagenic for TA 1535, designed to detect substitution mutations. The 10,11-epoxides of the three drugs, carbamazepine, cyproheptadine and cyclobenzaprine, were not cytotoxic to any of the bacterial tester strains used, precluding that mutagenic…
The diagnostic significance of intrahepatocellular hepatitis-B-surface-antigen (HB s Ag), hepatitis-B-core-antigen (HB c Ag) and IgG for the classifi…
1975
Liver biopsies of patients with inflammatory liver diseases and clinically healthy HBsAg-carriers were examined for presence of intracellular HBsAg, HBcAg and IgG by direct immunofluorescence. The studies revealed the following results: 1. In most cases healthy HBsAg-carriers had HBsAg in the cytoplasm, but they did never show HBcAg in the nuclei of hepatocytes. 2. In the early phase some patients with HBsAg-positive acute hepatitis had HBcAg and/or HBsAg in their hepatocytes. In a normal course with complete recovery the immunoelimination may clear either phenomenon at variable stages of the disease. 3. Cases one year after complete recovery of acute virus B-hepatitis had no HB-components …
Organ-specificity and diagnostic value of cell-mediated immunity against a liver-specific membrane protein: Studies in hepatic and non-hepatic diseas…
1975
In chronic active hepatitis (CAH, n=58) 70% of the HBsAg negative and 48% of the HBsAg positive cases showed a CMI against human liver specific proteins (HLPI). Using HBsAg as antigen only 12% of the HBsAg negative and 24% of the HBsAg positive cases gave a CMI response. On the basis of HBsAg and autoantibodies in the serum CAH patients could be divided into 4 subgroups. A close correlation between CMI against HLPI, sex, ANA and HL-A-8 could be detected. In a follow-up study of patients with acute virus B hepatitis (n=62) CMI against HBsAg was detected in 60% of the cases in the acute phase of the disease but in 15% only 3-6 months after the onset of the illness (n=40). In patients who deve…
Muscarinic inhibition of potassium-induced noradrenaline release and its dependence on the calcium concentration.
1975
1. Noradrenaline release from the isolated rabbit heart was evoked by perfusion with a medium containing 135 mM potassium and 17 mM sodium ions (high K+-low Na+). 2. The noradrenaline output in response to high K+-low Na+ was dose-dependently decreased by methacholine (0.625-320 muM) and this effect was reserved by atropine 1.44 mM. 3. Lowering the calcium concentration of high K+-low Na+ from 1.8-0.1125 mM decreased the noradrenaline output by 85%. The effect of methacholine, expressed as % inhibition of noradrenaline release, was potentiated by lowering of the calcium concentration. 4. Both at normal and lowered calcium concentrations the inhibitory action of methacholine was larger from …
Suitability of non-glucose-carbohydrates for parenteral nutrition
1975
Postoperative parenteral nutrition can only be optimally effective if the characteristics of post-traumatic metabolism are taken into account. Two main possibilities are discussed for the carbohydrate component of parenteral nutrition during this phase: glucose with high doses of insulin or non-glucose carbohydrates (sugar substitutes) possibly in a suitable combination with glucose. The risks as well as the technical and organisational problems involved in the use of them are discussed and the authors prefer the second of the two alternatives. Possible side effects of non-glucose carbohydrates are pointed out and it is shown how these can be avoided by observing dose guidelines. So far a c…
Evidence for noradrenaline and adrenaline as sympathetic transmitters in the chicken.
1975
1 The concentrations of noradrenaline and adrenaline in various organs, arterial plasma and venous outflow from isolated hearts of adult chickens have been determined. 2 The relative adrenaline concentrations (percentage of the sum of noradrenaline and adrenaline) in the heart (33%), spleen (16%) and brain (26%) were higher than those found in mammalian organs. Chemical sympathectomy by pretreatment with 6-hydroxydopamine caused a decrease of the noradrenaline and adrenaline concentrations in the heart to 20 and 23% and in the spleen to 16 and 29%, respectively. 3 Stimulation of the right sympathetic nerves, infusion of tyramine or infusion of a modified Tyrode solution containing 108mM K+ …
Zur absoluten Konfiguration von chiralem Benzylmethyl‐α‐naphthylphenylphosphonium‐bromid
1975
Es wird auf experimentellem Wege gezeigt und durch weitere analoge Beispiele untermauert, das dem linksdrehenden Benzylmethyl-α-naphthylphenylphosphonium-bromid ((–)-2) – im Gegensatz zu dem fruheren Befund anderer Autoren15) – die S-Konfiguration zuzuordnen ist. The Absolute Configuration of Chiral Benzylmethyl-α-naphthylphenylphosphonium Bromide It is shown experimentally and supported by further analogous examples, that the S-configuration must be attributed to chiral (–)-benzylmethyl-α-naphthylphenylphosphonium bromide (–)-2, in contrast to an earlier assignment by other authors15).
Some determinants of the migration of professional manpower.
1975
Abstract Determinants of migration of professional manpower are investigated using data from a 1970 survey of immigrants to the United States. From a respondent’s stated “intent to stay” in the United States and five other characteristics a six-dimensional contingency table is formed. We find a well-fitting log-linear model for this table. Thus, we establish the importance of selected determinants of migration and present a table of predicted rates of intent to stay in the United States
Accumulation of polycyclic aromatic hydrocarbons in cultivated microalgae.
1975
Alterations of DNA-dependent DNA polymerase activities in the immature quail oviduct in response to estrogen stimulation.
1975
Administration of diethylstilbestrol, an estrogen analogue, to immature female quails causes an increase of extractable DNA-dependent DNA polymerase activities from the oviduct. At least two forms of polymerases have been determined, a high molecular weight polymerase (210,000 daltons) and a low molecular weight polymerase (34,000 daltons) calculated from column chromatography Sephadex G-200. During the primary hormone stimulation the amount of extractable enzyme reaches a maximum on the fifth day after daily injections of the hormone. In the period of withdrawal the activities decrease and reach values similar to those determined in the unstimulated oviducts. During secondary stimulation t…
ACTIONS OF PROSTAGLANDIN E2 ON MYOCARDIAL MECHANICS, CORONARY VASCULAR RESISTANCE AND OXYGEN CONSUMPTION IN THE GUINEA-PIG ISOLATED HEART PREPARATION
1975
Abstract 1 In isolated, electrically driven (3 Hz) hearts of guinea-pigs the action of prostaglandin E2 on left ventricular pressure (LVP), oxygen consumption (Qo2) and coronary vascular resistance (CVR) was studied by establishing cumulative concentration-response curves. The hearts were perfused at a constant flow (10 ml/min) with Tyrode solution (Ca++ 1.8 mM) at 32 degrees C. 2 Under control conditions prostaglandin E2 (2.86 X10(-11) -1.43 X 10(-7) M) decreased LVP, QO2 and CVR in a concentration-dependent manner by maximally 27, 18 and 38%, respectively (P less than 0.05). 3 After reserpine pretreatment there were lower initial values for all parameters measured. The effect of prostagla…
Kristall‐ und Molekülstruktur sowie absolute Konfiguration des (+)‐Benzylmethyl‐α‐naphthylphenylphosphonium‐bromids
1975
(+)-Benzylmethyl-α-naphthylphenylphosphonium-bromid kristallisiert in der Raumgruppe P212121 mit den Gitterkonstanten a = 22.12 A, b = 9.89 A,c = 9.49A und mit vier Molekulen in der Elementarzelle. Die Struktur wurde nach der Schweratommethode aufgeklart und bis zu einem R-Wert von 5.8% verfeinert. Unter Berucksichtigung der anomalen Dispersion konnte die absolute Konfiguration ermittelt werden, es liegt R-Konfiguration vor. Crystal- and Molecular Structure of (+)-Benzylmethyl-α-naphthylphenylphosphonium Bromide (+)-Benzylmethyl-α-naphthylphenylphosphonium bromide crystallizes in the space group P212121 with four molecules in the unit cell of dimensions a = 22.12 A, b = 9.89 A, c = 9.49 A. …
Stereospezifische Überführung chiraler acyclischer tertiärer Phosphinsulfide in die entsprechenden tertiären Phosphinoxide mit Dimethylsulfoxid (DMSO)
1975
Die Uberfuhrung chiraler acyclischer tertiarer Phosphinsulfide in die entsprechenden tertiaren Phosphinoxide mit DMSO in saurer Losung erfolgt unter vollstandiger Inversion der Konfiguration am zentralen Phosphoratom. Aufgrund dieses stereochemischen Verlaufs wird ein Mechanismus fur die Reaktion zur Diskussion gestellt. Stereospecific Conversion of Chiral Acyclic Tertiary Phosphine Sulfides into the Corresponding Tertiary Phosphine Oxides by Means of Dimethyl Sulfoxide (DMSO) The conversion of chiral acyclic tertiary phosphine sulfides into the corresponding tertiary phosphine oxides by means of DMSO in acidic solution proceeds with complete inversion of configuration at the central phosph…
Deoxyribonuclease activities in human leukemic cells and mouse lymphoblasts
1975
Summary The deoxyribonuclease activities from human lymphocytes have been compared with the activities from acute lymphocytic leukemic cells and mouse leukemic cells L5178Y using the in situ detection of deoxyribonucleases in DNA-containing polyacrylamide gels following their separation by micro-disc-electrophoresis. A neutral deoxyribonuclease activity is completely missing in leukemic cells of untreated patients while a group of acid deoxyribonuclease activities is increased. A similar deoxyribonuclease pattern can be seen in L5178Y cells. Under medical treatment the increment of the acid deoxyribonuclease activities disappears and the neutral deoxyribonuclease activity reappears.
Perceptual Performance as a Function of Intra-Cycle Cardiac Activity
1975
The purpose of the experiment was to test the hypothesis of a systematic change in perceptual performance within a single cardiac cycle due to the activity of the baroreceptors in carotid sinus. As an index of perceptual performance the ds-parameter from signal detection theory (TSD) was used. A 1000 Hz sine tone had to be detected in a background of white noise. Each of 4 subjects received on the average 4605 noise or noise plus tone stimuli distributed over 10 experimental sessions. When comparing performance during time intervals before and after baroreceptor activity onset no significant difference was found. Also, when tracing perceptual performance over the whole cardiac cycle in step…
Unbekannte Leichen: Identifizierung mit einem Informationspool aus Gebi�daten. Praktische Vorschl�ge f�r die Neugestaltung der Befunderhebung und Bef…
1975
The masticatory system has often proved very useful for the identification of unkown bodies. The technique of excising the mandible and the maxilla is explained. The evaluation and the preparation of models are described. For registration of the findings a new form has been developed. It is based on the old form "KP 16" as well as on the PA status.
Macrophage inhibiting activity in serum and central lymph of Listeria-immune mice.
1975
Serum and central lymph from mice immunized with live Listeria monocytogenes six days previously and boostered four hours before collection exerted significant inhibition of macrophage migration in vitro. It is concluded that lymphokines or lymphokine-like products of the cellular immune reaction are released in vivo and are possibly instrumental in the generation of acquired cellular antibacterial immunity.
Radiation tail and radiative corrections for elastic electron scattering
1975
Abstract A set of formulae, which is currently used to calculate radiative effects in electron scattering experiments, is discussed. Since these formulae contain approximations which fail to describe radiation losses properly a modified set is proposed. The radiation unfolding procedure of elastically scattered electrons is investigated in detail, account is taken of the different sets of formulae and of the finite energy resolution. The cross sections extracted from measured spectra depend on the formulae used in the unfolding procedure. For two measured Bi spectra they differ by up to 11%. With the modified set of formulae the unfolding procedure yields the same cross section as the appli…
L'aide aux étudiants en France : faits et critique
1975
référence interne : 75007
Polarographic determination of glycine with a dropping copper amalgam electrode
1975
The anodic oxidation of a dropping copper amalgam electrode in presence of dilute solutions of glycine in 0.50 M NaClO4 has been studied. An anodic wave at −0.28V (SCE) is observed, yielded by diffusion of glycinate anion in the solution towards the electrode surface. The wave-heights increase with the glycinate concentration (function of glycine concentration and pH value) until the anodic oxidation is controlled by the metal diffusion into mercury. The effect of pH is interpreted by attributing it to the depolarizer effects at glycinate anion even though the zwitterion is present in much larger concentrations. The applicability of anodic oxidation of a dropping copper amalgam electrode in…
Comparative statistical studies on the anthropology of the Iron Age (last millennium B.C.)
1975
Abstract Extending previous statistical studies on the anthropology of the Neolithic and Bronze Ages, anthropological material from the Iron Age (1000-0) was compiled and condensed into 71 series (population samples). Penrose distances were calculated on the basis of 10 skull measurements. The dendrogram consisting of 49 larger series shows a division into a west- and an east-cluster. The west-cluster can be broken down into a northern, entirely European section, and into a southern subcluster, stretching from Sardinia to Pakistan. The east-cluster differs from the west-cluster above all in the larger width measurements, as in the case with the north-east and south-west complexes in the Neo…
On the effect of quarter-wave-plate errors in stress-holo-interferometry
1975
Separation of deoxyribonucleases (DNases) of normal human stratum corneum and psoriatic scales by micro-disc-electrophoresis.
1975
Normal stratum corneum and psoriatic scales were homogenized and a differential centrifugation was performed. The DNase activity of the individual fractions was investigated by micro-disc-electrophoresis. At pH 5 only in the 600 × g pellet and 105.000 × g supernatant of normal keratin DNase activity could be observed. However, all psoriatic fractions showed distinct enzyme activities. At pH 7.4 little psoriatic DNase activity could only be demonstrated in the 105.000 × g supernatant. Except from the 15.000 × g pellet all fractions of normal stratum corneum displayed marked activities. In addition the 105.000 × g supernatant showed two different DNase bands.
Generalized Nutbrown representation of the vector vertex function and the magnetic moment of the chargedρmeson
1975
A former representation of the vector vertex function, due to Nutbrown, is generalized. It is shown how this resolves an apparent contradiction between the effective-Lagrangian and hard-meson techniques. Further possible applications are discussed. (AIP)
Sulfatide excreting heterozygous carrier of juvenile metachromatic leukodystrophy or asymptomatic patient of adult metachromatic leukodystrophy.
1975
In a family with juvenile metachromatic leukodystrophy (sulfatide lipidosis) 2 patients showed residual arysulfatase A activities of 5--6%. The patients' healthy father was characterized biochemically by a 39% normal activity of leukocyte plus plasma arylsulfatase A. The father was further characterized by a high sulfatide excretion (0.2--0.5 mg/I urine) and, paradoxically, by a normal sulfatide degrading enzyme activity in vitro. This special carrier is suspected to be heterozygous for a) arylsulfatase A deficiency and b) arylsulfatase A (sulfatidase) lability. This presumed additional genetic defect could be the cause of the sulfatide excretion which, in turn, would be a sign of the precl…
The determinants and effects of time spent studying in french higher education
1975
International audience
THE PREPARATION OF DIHYDROXYDIPHENYLMETHANES CONTAINING NITRO GROUPS. II. UNSYMMETRICALLY SUBSTITUTED COMPOUNDS
1975
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1975
Quantum chemical calculations of formyl radicals
1975
The ground state (2 A′) of the fluoroformyl radical, FCO, has been investigated by the unrestricted Hartree-Fock method. Pulay's force method for open-shell systems has been applied to calculate the complete quadratic force field and the diagonal cubic force constants. The force relaxation method has been used to determine the equilibrium geometry of FCO: . Adjusting the diagonal force constants to the observed vibrational frequencies of 19F12C16O and taking the values for the off-diagonal force constants from the UHF calculations, the force field of FCO is found to be: . This force field is compared with experiment and with the force fields of HCO, H2CO, and F2CO. The ground state of the F…
Neue Monomere durch Anwendung der Ugi-Reaktion
1975
Partial spreads in finite projective spaces and partial designs
1975
A partial t-spread of a projective space P is a collection 5 p of t-dimensional subspaces of P of the same order with the property that any point of P is contained in at most one element of 50. A partial t-spread 5 p of P is said to be a t-spread if each point of P is contained in an element of 5P; a partial t-spread which is not a spread will be called strictly partial. Partial t-spreads are frequently used for constructions of affine planes, nets, and Sperner spaces (see for instance Bruck and Bose [5], Barlotti and Cofman [2]). The extension of nets to affine planes is related to the following problem: When can a partial t-spread 5 ~ of a projective space P be embedded into a larger part…
Seasonal changes in some thermoregulatory variables of the house sparrow (Passer domesticus L.)
1975
Abstract 1. The body weight, plumage, insulation, oxygen consumption and body lipids were studied seasonally in the house sparrow, Passer domesticus L. 2. The weights of body and plumage were greater in autumn and winter than in summer. 3. The insulative property of the plumage was better in autumn and winter birds than in summer birds. 4. The oxygen consumption of young birds was higher than that of plucked and adult birds. 5. The amount of subcutaneous depot fat tissue and its lipid content was greatest in autumn. The C18-unsaturated fatty acids were most prominent in the subcutaneous fat. Palmitic acid was the most prevalent fatty acid in the liver. The relative amount of C18-unsaturated…