showing 36 of ~574560 from 574555 documents

Assia Djebar o della scrittura liberatrice

1993

Settore L-FIL-LET/14 - Critica Letteraria E Letterature ComparateLetteratura francofona Algeria Maghreb

Naturaleza y alcance del método lógico del Fedón

1993

En la biografía intelectual de Sócrates que Platón relata en el Fedón, aquél, cuando describe su"segunda singladura" (99d) en la investigación de"la causa de la generación y de la destrucción de las cosas" (95d), apela en varias ocasiones a un método de investigación alternativo al empleado por los antiguos fisiólogos: método al que suele aludirse en la bibliografía sobre Platón con el rótulo de método lógico. El objetivo de este trabajo es doble: esclarecer, por una parte, la naturaleza de dicho método y su relación con la dialéctica; y, por otra, examinar su alcance y sus presupuestos.

lcsh:Philosophy (General)Lògicalcsh:BD10-701lcsh:Speculative philosophylcsh:B1-5802Historia de la FilosofíaInteligencia artificial

El espectáculo del poder: Aproximación a la fiesta política en la Valencia de los siglos XVI y XVII

1993

:HISTORIA::Historia moderna [UNESCO]HumanidadesUNESCO::HISTORIA::Historia modernaHistoria

Radiosurgery of Epilepsy

1993

Since 1982 a series of 11 epileptic patients have been treated with stereotactic radiosurgery. Patients were intracranially recorded with cortical and deep electrodes until the location of the epileptogenic focus was determined. A deep electrode was stereotactically placed at this point to confirm the accuracy of the location. All patients received radiosurgery with a gamma source and a dose of 10 to 20 Gy, except two of them in which a betatron was used. The results were: Total disappearance of the crises and withdrawal of medication: 4 cases (36%). More than 80% reduction of crises: 3 cases (27%). More than 50% reduction of crises: 2 cases (18%). Less than 50% reduction of crises: 2 cases…

Epileptogenic focusEpilepsymedicine.diagnostic_testbusiness.industrymedicine.medical_treatmentTreatment outcomeMedicineEpilepsy surgeryElectroencephalographybusinessNuclear medicinemedicine.diseaseRadiosurgery

Laser spectroscopy and the properties of light nuclei near the neutron drip line

1993

The interesting nuclear structure phenomena observed in some light nuclei at the neutron drip line suggest the measurement of basic ground state properties such as spins, magnetic moments and electric quadrupole moments. Here it will be discussed what experiments are presently feasable using laser spectroscopy. For the outstanding example of a “halo” nucleus,11Li, the development of a technique combining β-asymmetry detected optical pumping in a fast beam with NMR spectroscopy has yielded pertinent results, the most recent of which is an experimental value of the nuclear quadrupole moment.

Nuclear and High Energy PhysicsMagnetic momentChemistryNuclear TheoryNuclear magnetic resonance spectroscopyCondensed Matter PhysicsAtomic and Molecular Physics and OpticsOptical pumpingQuadrupoleNuclear drip linePhysical and Theoretical ChemistryAtomic physicsNuclear ExperimentSpectroscopyGround stateTwo-dimensional nuclear magnetic resonance spectroscopyHyperfine Interactions

A hybrid scheme for action representation

1993

Strong deficiencies are present in symbolic models for action representation and planning, regarding mainly the difficulty of coping with real, complex environments. These deficiencies can be attributed to several problems, such as the inadequacy in coping with incompletely structured situations, the difficulty of interacting with visual and motorial aspects, the difficulty in representing low-level knowledge, the need to specify the problem at a high level of detail, and so on. Besides the purely symbolic approaches, several nonsymbolic models have been developed, such as the recent class of subsym-bolic techniques. A promising paradigm for the modeling of reasoning, which combines feature…

Knowledge representation and reasoningbusiness.industryComputer scienceAnalogical modelsInferenceHybrid approachSymbolic data analysisTheoretical Computer ScienceHuman-Computer InteractionArtificial IntelligenceAdaptive systemThe SymbolicArtificial intelligencebusinessHybrid modelSoftwareInternational Journal of Intelligent Systems

Ability of Wine Lactic Acid Bacteria to Metabolize Phenol Carboxylic Acids

1993

International audience

[SDV.SA.STA]Life Sciences [q-bio]/Agricultural sciences/Sciences and technics of agriculture[SDV.SA.STA] Life Sciences [q-bio]/Agricultural sciences/Sciences and technics of agricultureHorticultureComputingMilieux_MISCELLANEOUSFood ScienceAmerican Journal of Enology and Viticulture

The Application of Salicylic Acid Amide for 4-Dimethylaminoaniline Determination

1993

diaminopeptidaze IV activity determination4-dimethylaminoaniline determinationChemia Analityczna

PROVE COMPARATIVE SULLA RICHIESTA DI ENERGIA NECESSARIA PER L'ESTRAZIONE DELL'OLIO DALLE OLIVE E DALLE SANSE DI LAVORAZIONE

1993

ENERGIA ESTRAZIONE OLIO DI OLIVA E SANSESettore AGR/09 - Meccanica Agraria

Historia de la Universidad de Valladolid

1993

Historia moderna y contemporáneaUNESCO::HumanidadesHistoria

Rotifer vertical distributions in a meromictic basin of Lake Banyoles (Spain)

1993

The vertical distribution of rotifer populations has been analyzed in a meromictic basin (III) of the karstic Lake Banyoles. This basin had, at the time of the study, an anaerobic monimolimnion from around 17 m in summer or 21 in winter to 25 m, its maximum depth. However, below this layer a warmer micro aerophiliczone with suspended marls is found in a chimney to a depth of 130 m.

geographygeography.geographical_feature_categorybiologyEcologyRotiferEcological successionStructural basinKarstbiology.organism_classificationPopulation densityZooplanktonOceanographyMarlChimneyGeology

Laser depassivation of a channel flow double-electrode: A new technique in repassivation studies

1993

Abstract A powerful tool for distinguishing between the different electrochemical steps involved during a depassivation-repassivation sequence was developed by combining the pulsed laser depassivation technique with an hydrodynamic electrochemical method: the channel flow double-electrode (CFDE). This experiment consisted of transporting the chemical species (Fe 2+ ) released by a depassivated iron electrode to a collecting electrode where these species were oxidized. A qualitative idea of the relative contribution of the anodic dissolution to the repassivation behavior was obtained. For a passive iron in acidic solution it was found that about 15% of the total charge is related to anodic d…

General Chemical EngineeringMetallurgyInorganic chemistryGeneral ChemistryLaserElectrochemistryCorrosionOpen-channel flowlaw.inventionchemistry.chemical_compoundChemical specieschemistrylawElectrodeGeneral Materials ScienceAnodic dissolutionPerchloric acidCorrosion Science

Chapter 23: Choline, a precursor of acetylcholine and phospholipids in the brain

1993

Publisher Summary The plasma level of free choline is remarkably constant at about 10 pM in animals and human. Ingestion of food, especially when rich in choline or lecithin, transiently elevates the plasma choline level up to 20 pM or more. In contrast, choline-deficient diet leads to a reduction of the plasma level by about 50%. Choline is considered an essential nutrient, which is predominantly supplied as phosphatidylcholine (lecithin). For a long time, neuroscientists have been intrigued by the fact that choline is a precursor for the biosynthesis of both acetylcholine (ACh) and phospholipids. For 50 years, lecithin has been marketed in Europe as a drug that was claimed to prevent exha…

medicine.medical_specialtyfood.ingredientMembrane lipidsPhospholipidLecithinchemistry.chemical_compoundfoodEndocrinologychemistryPhosphatidylcholineInternal medicinemedicineCholinergicCholineHomeostasisAcetylcholinemedicine.drug

University?Industry Relations in France

1993

International audience; This paper summarises the key developments in university-industry relations in France in recent years. The overall trend is seen to be one in which there has been a movement away from dependence on the state and towards a diversity of the types of co-operation between firms and institutions of higher education.

Higher educationbusiness.industryMovement (music)[SHS.EDU]Humanities and Social Sciences/Education4. Educationmedia_common.quotation_subject[SHS.EDU] Humanities and Social Sciences/Education05 social sciences050301 education050905 science studiesRelation université-industrieEnseignement supérieurEducationState (polity)EconomyPolitical scienceKey (cryptography)France0509 other social sciencesbusiness0503 educationmedia_commonDiversity (business)Higher Education Quarterly

Experimental emetine myopathy: enzyme histochemical, electron microscopic, and immunomorphological studies.

1993

Ipecac, containing emetine hydrochloride, is used by patients with anorexia nervosa to induce vomiting. Its chronic usage may result in a myopathy and a cardiomyopathy, the former marked by cytoplasmic bodies. We studied myopathological changes after daily injections of female Wistar rats with emetine hydrochloride intraperitoneally for periods of 4, 5, 9, and 10 weeks. the extensor digitorum longus muscle and the soleus muscle showed core-like lesions, streaming of the z-discs, nemaline bodies, cytoplasmic bodies, and spheroid cytoplasmic bodies. Immunomorphological studies revealed increased amounts of desmin. During a period of repair, i.e., 2, 4, and 6 weeks after termination of emetine…

Pathologymedicine.medical_specialtyEmetineEmetine HydrochlorideEmetineBiologyPathology and Forensic MedicineDesminExtensor digitorum longus muscleExtensor digitorum muscleCellular and Molecular NeuroscienceMuscular DiseasesmedicineAnimalsRats WistarNemaline bodiesMyopathySoleus muscleMusclesImmunohistochemistryRatsMicroscopy ElectronDesminFemaleNeurology (clinical)medicine.symptommedicine.drugActa neuropathologica

L'ESPLORAZIONE DEI LINFONODI REGIONALI NEL NEUROBLASTOMA LOCALIZZATO: Compliance alle Direttive Chirurgiche nello Studio Nazionale NB 85

1993

Accurate staging of patients with Neuroblastoma is essential for prognosis and for determining the most appropriate treatment. The neoplastic involvement of regional lymph-nodes (l.n.) is an important prognostic feature; the surgical exploration of these L.n. is mandatory for localized neuroblastoma (NBL) (stage I and II) in wich surgery represent the main treatment. The Authors have carried out a retrospective analysis of the cases registered in Italy between 1985 and 1989

Settore MED/38 - Pediatria Generale E SpecialisticaSettore MED/20 - Chirurgia Pediatrica E InfantilePediatric tumours Neuroblastoma stage I and II treatment surgery surgical exploration of regional lymphnodes.

Sombras en el Siglo de las Luces, monstruos, demonios y prodigios en la estampería popular del siglo XVIII

1993

LOS ESTUDIOS DE CONJUNTO DE LA ESTAMPA POPULAR SON ESCASOS EN ESPAÑA, ABUNDANDO MUCHO MAS, COMO OCURRE CON OTRAS AREAS CULTURALES, EN LOS ESTUDIOS DE LITERATURA O FOLKLORE. MUY INTERESANTES SON LAS ILUSTRACIONES IMPRESAS DE LA LLAMADA LITERATURA DE CORDEL, QUE ECLOSIONA EN EL SIGLO XVIII Y TIENE COMO CENTRO PRINCIPAL DE PRODUCCION LA CIUDAD DE VALENCIA. EN LAS XILOGRAFIAS DE LAS CABECERAS DE LOS ROMANCES DESFILAN MONSTRUOS, ANIMALES FANTASTICOS, SERES DEMONIACOS, VISIONES CELESTIALES Y TODA UNA SERIE DE IMAGENES SOMBRIAS DE RAICES BARROCAS E INCLUSO MEDIEVALES, QUE CONTRASTAN CON LOS GUSTOS RACIONALISTAS QUE DOMINABAN EN LA CULTURA OFICIAL (ABC/LAG).

Arte popularEstampasUNESCO::HISTORIA::Historia por especialidades::Historia del arteSeres fantásticosAnimales fantásticosIconografía:HISTORIA::Historia por especialidades::Historia del arte [UNESCO]GrabadoRomance

Entorno geográfico del hombre del bronce: Implicaciones geoarqueológicas

1993

El estudio sedimentológico, geomorfológico y edáfico del entorno de cuatro yacimientos del periodo cultural del Bronce situados en el País Valenciano, permite conocer algunos rasgos del medio físico en el que los hombres de esta época desarrollan sus actividades, y aporta nuevas variables a tener en cuenta por el arqueólogo. Las investigaciones ponen en evidencia una activa morfogénesis que ha modificado, en parte, el paisaje, y una tendencia climática hacia el incremento de la sequedad. Palabras clave: Geoarqueología, paleoambiente, Holoceno superior: Edad del Bronce, suelos, País Valenciano.

GeografíaUNESCO::HISTORIAGeociencias. Medio ambienteGrupo B:HISTORIA [UNESCO]

Los niveles romanos de la iglesia de San Salvador (Sagunto)

1993

lcsh:CHumanidadeslcsh:Archaeologylcsh:CC1-960lcsh:Auxiliary sciences of historyHistoriaUNESCO::HISTORIA::Ciencias auxiliares de la historia::Arqueología:HISTORIA::Ciencias auxiliares de la historia::Arqueología [UNESCO]

FELIPO ORTS,Amparo La universidad de Valencia durante el siglo XVII (1611-1707) [Reseña]

1993

Reseña de La universidad de Valencia durante el siglo XVII (1611-1707).

Evaluation of the API 20E system for identification and discrimination of Vibrio vulnificus biotypes 1 and 2

1993

biologyVeterinary (miscellaneous)Identification (biology)Vibrio vulnificusAquatic Sciencebiology.organism_classificationMicrobiologyJournal of Fish Diseases

Chronic toxicity of methylparathion to the rotifer Brachionus calyciflorus fed on Nannochloris oculata and Chlorella pyrenoidosa

1993

The effect of sublethal levels of methylparathion (0,1, 3, 5, 7 mg 1−1) on the freshwater rotifer, Brachionus calyciflorus, during their entire life cycle was studied. Rotifers were fed on two species of unicellular algae: Nannochloris oculata and Chlorella pyrenoidosa; both algal concentrations were 5 × 105 cell ml−1.

Mortality indexbiologyAlgaeNannochloris oculataBotanyBrachionus calyciflorusEntire life cycleChlorella pyrenoidosaRotiferFood sciencebiology.organism_classificationChronic toxicity

gamma-Interferon, interleukin-4 and interleukin-6 in vitro production in old subjects.

1993

It is well known that ageing is associated with various alterations of the lymphoid cell functions. Although both B and T cell are affected, the last appear to be more sensitive to ageing process. During the past years, to gain insight into thé mechanism(s) of this impairment, effort has been centered on the helper T cells specifically engaged in the production of interleukin-2 (IL-2) because of the pivotal role played by this cytokine in the activation of several immune functions. The results have demonstrated that the ability to produce IL-2 declines with age. In this paper we report the results of a study performed to determine the influence of age on the capacity to produce gamma-interf…

AdultMaleAgingmedicine.medical_treatmentT cellImmunologyLymphocyte ActivationPeripheral blood mononuclear cellInterferon-gammaImmune systemmedicineImmunology and AllergyHumansInterferon gammaInterleukin 6Interleukin 4Cells CulturedAgedAged 80 and overbiologyInterleukin-6Middle AgedCytokinemedicine.anatomical_structureAgeingImmunologybiology.proteinLeukocytes MononuclearFemaleInterleukin-4Immunocompetencemedicine.drugAutoimmunity

VINCENT, Bemard: 1492: el año admirable [Reseña] Barcelona, Editorial Crítica, 1992, 206 págs. (Colección Drakontos)

1993

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A novel synthesis of polymers with anthracene and dihydroanthracene subunits in the main chain

1993

A new polycondensation method to connect redox-active and chromophoric subunits by forming a C-C bond and leading to a polyhydrocarbon is described. 1,ω-bis(9,10-Dihydro-9-anthry)alkanes with various alkylene spacers can be deprotonated by butyllithium to afford a monoanion in each dihydroanthracene moiety. Alkylation with dielectrophiles such as dibromoalkanes yields soluble polymers with dihydroanthracene units in the main chain. The reaction proceeds regioselectively in the 9,10-position. Aromatization generates a polymer with anthracene units. The molecular weights are determined by GPC up to Mn = 10 000. To prove the structure and to calibrate the GPC, suitable model compounds were syn…

chemistry.chemical_classificationAnthraceneCondensation polymerPolymers and PlasticsOrganic ChemistryAromatizationPolymerAlkylationchemistry.chemical_compoundDeprotonationchemistryPolymer chemistryMaterials ChemistryButyllithiumMoietyPolymer International

Study of a lipase from Candida rugosa Diddens and Lodder

1993

Lipasic system of Candida rugosa (CBS 613) strain was studied. The enzyme was purified in one step by hydrophobic chromatography. The properties of this lipase were determined. It is an oligomeric enzyme composed of five identical monomers of 46 kg · mol−1. Its optimum reaction conditions are pH = 7 and temperature = 40°C. This enzyme presents a rapid thermal denaturation and then a more stable form. It is a cell-bound lipase which is induced by triacyl glycerols. This enzyme presents a high specificity for external positions on glycerol. Unterschung einer Lipase aus Candida rugosa Diddens und Lodder Die Reinigung einer Lipase aus Candida rugosa (CBS 613) wurde in einer einzigen Stufe durch…

chemistry.chemical_classificationbiologyStereochemistry[SDV]Life Sciences [q-bio]Triacylglycerol lipaseFungi imperfectibiology.organism_classificationYeastCandida rugosa[SDV] Life Sciences [q-bio]EnzymechemistryBiochemistrybiology.proteinSubstrate specificityLipase

Lipoprotein a) levels in end-stage renal failure and renal transplantation

1993

Some previous studies have documented an increase in lipoprotein (a) [Lp(a)] levels in renal diseases. Here, we report data in subjects with end-stage renal failure treated with hemodialysis (HD) or with continuous ambulatory peritoneal dialysis (CAPD) and in renal transplant recipients (RTR), compared with a group of normolipidemic controls (C). Lp(a) levels were significantly increased in HD and CAPD patients in comparison with C, while they were only slightly increased in RTR. Both HD and CAPD patients showed Lp(a) levels higher than in RTR, but no difference was found between the subjects of the two dialysis procedures. The prevalence of Lp(a) levels > 25 mg/dl was significantly higher …

AdultMalemedicine.medical_specialtymedicine.medical_treatmentUrologyurologic and male genital diseasesNephropathyPeritoneal dialysisPeritoneal Dialysis Continuous AmbulatoryRenal DialysisRisk FactorsHumansMedicineAgedKidneybiologybusiness.industryContinuous ambulatory peritoneal dialysisLipoprotein(a)Middle Agedmedicine.diseaseKidney TransplantationSurgeryTransplantationmedicine.anatomical_structureCardiovascular Diseasesbiology.proteinKidney Failure ChronicFemaleHemodialysisbusinessLipoprotein(a)Lipoprotein

false

1993

Lobsters and dolphins are adapted to aquatic life whereas the green woodpecker and the fly are adapted to aerial life. The way in which these organisms are constructed allows them to execute certain functions within certain environments. This is a first, simple definition of adaptation which describes:The evolutionary process of adjustment of an organism to its environment. This historical aspect will be discussed in subsequent chapters.The result of this process — the state of adaptation — or the form of an organism at a certain point in its history. This functional-structural aspect will be dealt with here.

biologyHuman–computer interactionProcess (engineering)Computer scienceWoodpeckerbiology.organism_classificationAdaptation (computer science)OrganismSimple (philosophy)

Recent Experimental Results with the PSTM: - Observation of a Step on a Quartz Surface. - Spatial Spectroscopy of Microwaveguides

1993

The Photon Scanning Tunneling Microscope (PSTM) is based on the frustration of the total internal reflected beam by the end of an optical fiber. Till today it has been used to obtain topographic information generally for smooth samples. In this paper we report two different kinds of experimental results. First, when the sample is in the form of a step, our measurements demonstrate how the images, obtained in the constant intensity mode, depend on the orientation of the incident beam of light with respect to the step. Next, we show that the first derivative of the collected intensity with respect to the probe-sample distance at each point of the sample yields to a new kind of image named her…

Total internal reflectionOptical fiberMaterials sciencePhotonOrientation (computer vision)business.industrylaw.inventionOpticslawScanning tunneling microscopeSpectroscopybusinessRefractive indexBeam (structure)

Diversity of meiofauna in the lacustrine profundal zone: Bathymetric differences and influence of environmental factors

1993

The diversity and species richness of total meiofauna, Harpacticoida and Oligochaeta in relation to depth and other environmental variables were studied at nine stations and in two profundal depth zones in Lake Paijanne which includes both oligotrophic and eutrophicated or organically loaded areas.

EcologybiologyEcologyMeiobenthosSpecies diversityAquatic Sciencebiology.organism_classificationBenthosBenthic zoneProfundal zoneBathymetrySpecies richnessHarpacticoidaEcology Evolution Behavior and SystematicsWater Science and TechnologyAquatic Sciences

Physical-mechanical effects of Nd:YAG laser on the surface of sound dental enamel.

1993

Human dental enamel samples were irradiated using a 5 kHz Q-Switched Nd:YAG laser. An increase in Knoop microhardness and modification of the membrane permselectivity were detached. These results and the changes observed by SEM, can be connected with the fusion of the enamel surface.

Materials scienceBiophysicsDentistryBioengineeringIndentation hardnesslaw.inventionMembrane PotentialsBiomaterialsstomatognathic systemlawMicroscopymedicineHumansBicuspidIrradiationHardness TestsComposite materialDental EnamelEnamel paintbusiness.industryLasersLaserTooth enamelstomatognathic diseasesmedicine.anatomical_structureMechanics of MaterialsNd:YAG laservisual_artCeramics and CompositesKnoop hardness testvisual_art.visual_art_mediumMicroscopy Electron Scanningsense organsbusinessBiomaterials

Use of solid state fermentation to produce Beauveria bassiana for the biological control of european corn borer

1993

The production process of a new bioinsecticide against european corn borer is described. The entomopathogenic fungus, Beauveria bassiana, is cultivated by Solid State Fermentation (SSF). The culture support chosen, clay microgranules, humidified with optimal nutritive solution, is incubated in optimal conditions during 48 hours, then dried for 5 days. The bioinsecticide can be directly used after harvesting, without formulation. This process is original for several reasons : - The granulometry (500 microm) and the bulk density (0.6) of the microgranules are compatible with the mechanical standard application of pesticides on corn. - The bioinsecticide could be produced in a pilot reactor of…

0106 biological sciencesEuropean corn borerPYRALIDE[SDV.BIO]Life Sciences [q-bio]/BiotechnologyBiological pest controlBeauveria bassianaBiomassBioengineering01 natural sciencesApplied Microbiology and Biotechnology03 medical and health sciences010608 biotechnologyBioreactorCONTROLE BIOLOGIQUEComputingMilieux_MISCELLANEOUS2. Zero hunger0303 health sciencesbiology030306 microbiologybusiness.industryPesticidebiology.organism_classificationBiotechnology[SDV.BIO] Life Sciences [q-bio]/BiotechnologyHorticultureSolid-state fermentationFERMENTATION ETAT SOLIDEEntomopathogenic fungusbusinessBiotechnology

General principles of reactor design and operation for SSC

1993

International audience

[SDV] Life Sciences [q-bio][SDV]Life Sciences [q-bio]MISE AU POINTCONTROLEComputingMilieux_MISCELLANEOUS

Aspectos psicosociales comprometidos con la adaptación de inmigrantes

1993

:PSICOLOGÍA [UNESCO]UNESCO::PSICOLOGÍAPsychology Social

Crystallization Behaviour at High Cooling Rates of Two Polypropylenes

1993

Phase distribution of quenched samples of two isotactic polypropylenes, having different molecular weight distributions, was evaluated by a deconvolution procedure of WAXD spectra. The dependence on cooling rate of the two resins shows the low molecular weights rich polymer is characterized by a faster kinetics with an α-monoclinic to mesomorphic transition taking place at higher cooling rates.

chemistry.chemical_classificationMaterials scienceKineticsThermodynamicsCooling ratesPolymerSpectral linelaw.inventionchemistrylawPhase (matter)TacticityMolar mass distributionCrystallization

Improved identification of heterozygotes for phenylketonuria using blood neopterin and biopterin

1993

A novel approach that combines information provided by the metabolism of pteridines and that of phenylalanine has been applied to the detection of heterozygotes for phenylketonuria. Phenylalanine, tyrosine, biopterin and neopterin have been measured in serum from normal controls and heterozygotes for classical phenylketonuria, before and after a phenylalanine oral load. Significant differences in neopterin and biopterin mean values in fasting serum and in the mean increase of biopterin induced by the phenylalanine load were found between groups. Inclusion of pteridine data in the discriminant analysis significantly improved the resolution of the classical phenylalanine loading test for the …

AdultMalemedicine.medical_specialtyPhenylalanineBiopterinPhenylalanineNeopterinchemistry.chemical_compoundPhenylketonuriasInternal medicineClassical phenylketonuriaGeneticsmedicineHumansTyrosineGenetics (clinical)ChemistryGenetic Carrier ScreeningNeopterinHeterozygote advantageTetrahydrobiopterinBiopterinEndocrinologyTyrosineFemalemedicine.drugPteridineJournal of Inherited Metabolic Disease