Die kristallstruktur von oligo[(2-hydroxy-1,3-phenylen)methylen]en

1984

The crystal structure of three tetranuclear phenolic compounds – 6,6′-bis (2-hydroxy-5-methylbenzyl)-4,4′-dimethyl-2,2′-methylenediphenol (1), 6-(2-hydroxy-3,5-dimethylbenzyl)-6′-(2-hydroxy-5-methylbenzyl)-4,4′-dimethyl-2,2′-methylendiphenol (2), and 6-(3-tert-butyl-2-hydroxy-5-methylbenzyl)-6′-(2-hydroxy-5-methylbenzyl)-4,4′-dimethyl-2,2′-methylene-diphenol (3) –, was determined by single crystal X-ray analysis. Intramolecular hydrogen bonds between all hydroxyl groups of adjacent phenolic units are found for all molecules. They are directed to the opposite end of the molecule by the ortho-methyl or ortho-tert-butyl group in compounds 2 and 3, while no special orientation is found in 1. Th…

false

1984

Dissolution de polystyrene marque par de la fluorescence dans une matrice de masse moleculaire moyenne en poids de 110000

Pharmacological analysis of the responsiveness of guinea-pig lung parenchymal strip to dopamine

1984

Abstract Responses to dopamine were examined in the guinea-pig isolated lung parenchymal strip. Complete cumulative concentration-response curves to dopamine exhibited a biphasic pattern with a small initial contraction at concentrations below 10(-5) M followed by a dose-dependent relaxation at higher concentrations. Phentolamine (10(-5) M) completely abolished the contractile component and enhanced sensitivity and maximal relaxation to dopamine. In the presence of phentolamine, propranolol antagonized the dopamine-induced relaxation (pA2 = 8.54 +/- 0.07). In the presence of propranolol (10(-6) M), dopamine produced a dose-related contraction displaced to the right by phentolamine. Incubati…

Endurance training decreases the alkaline proteolytic activity in mouse skeletal muscles.

1984

Alkaline and myofibrillar protease activities of rectus femoris, soleus, and tibialis anterior muscles and the pooled sample of gastrocnemius and plantaris muscles were analyzed in male NMRI-mice during a running-training program of 3, 10, or 20 daily 1-h sessions. The activity of citrate synthase increased during the endurance training, reflecting the increased oxidative capacity of skeletal muscles. The activities of alkaline and myofibrillar proteases continually decreased in the course of the training program in all muscles studied. Instead, the activity of beta-glucuronidase (a marker of lysosomal hydrolases) increased in all muscles. The highest activities were observed at the beginni…

Electrical responses of homing pigeon and guinea pig Purkinje cells to pineal indoleamines applied by microelectrophoresis

1984

The effects of microelectrophoretically applied melatonin (aMT), 5-methoxytryptophol (ML), 5-hydroxytryptophol (HL) and noradrenaline (NA) on the electrical activity of cerebellar Purkinje and other cells during both day- and nighttime were studied in urethane-anesthetized intact and pinealectomized homing pigeons and guinea pigs.

Inhibition of the herpes simplex virus-coded thymidine kinase-complex by 9-?-D-arabinofuranosyladenine 5?-monophosphate (ara-AMP) and 9-(2-hydroxyeth…

1984

The thymidine kinase-complex isolated from herpes simplex virus type 1 and type 2 (HSV-1 and HSV-2) is associated with the following enzyme activities: ATP:dThd (dCyd) deoxypyrimidine kinase, ATP:dTMP thymidylate kinase, ADP:dThd- and AMP:dThd5′-phosphotransferase. In kinetic experiments it is shown that ara-AMP inhibits AMP:dThd- and ADP:dThd phosphotransferase activity, while acyclo-GMP impairs ADP:dThd phosphotransferase reaction only; the inhibition was found to be non-compertitive. The functional subunit ATP:dThd kinase was not affected by either compound.

La natation au bac : un choix ?

1984

International audience

Rat CNS cell culture. Enhancement of neuronal survival and delay of glial proliferation by serum from patients with multiple sclerosis. A morphologic…

1984

The addition of serum from multiple sclerosis (MS) patients to the culture medium of dissociated cells from cerebral hemispheres of rat embryos caused a delay in glial proliferation and an enhancement of neuronal survival. Sera from normal individuals and patients with other neurological diseases failed to show this effect. These morphological observations are interpreted as the outcome of inhibition of in vitro gliogenesis.

Sonographic evidence of intraperitoneal fluid. An experimental study and its clinical implications.

1984

In order to evaluate the sensitivity of ultrasound to intraperitoneal fluid, such as ascites or blood, an experimental study was performed in the pig. Various amounts of fluid were injected into the peritoneal cavity to investigate distribution and diagnostic criteria in different positions. As little as 10 ml of fluid was visualized around the urinary bladder in an upright position. In the supine position, 20 ml could be detected around the bladder and 30 ml around the liver. The injection of at least 60 ml resulted in a pattern of free-floating bowel loops. The sonographic findings of fluid distribution were correlated to radiological studies. As different amounts of fluid produce charact…

Interaction between C1-INA, coagulation, fibrinolysis and kinin system in hereditary angioneurotic edema (HANE) and urticaria.

1984

The C1-inactivator plays an important role not only in the initial phases of the complement system, but also in those of the coagulation, fibrinolysis and kinin systems. The present study was concerned with the reciprocal influence of decreased C1-inactivator levels in patients with hereditary angioneurotic edema (HANE, HAE). In 13 HANE-I patients there were significantly increased levels of the coagulation factors XII, XI, V, of plasminogen and of alpha 2-antiplasmin, while the factors IX and VII were decreased. Conversely, it emerged that in patients with markedly raised prephase factor levels, angioneurotic edema occurred in the presence of normal or only slightly decreased C1-inactivato…

Are simple striate cells analysers of visual signals both in spatial position as well as in spatial frequency?

1984

According to a modern view, simple cells of the cat striate cortex are considered to operate as apart of Fourier analysis system thus leading to the idea that the operational mechanism of the visual cortex is concerned with the analysis of spatial frequencies. Nevertheless if simple cells are really concerned only with the analysis of spatial frequencies there should exist a strict relationship between their spatial frequency selectivity and the spatial organization of their receptive fields. This is because it is the spatial organization of the spatial frequency detector i.e. the cell's receptive field that determines the cell's spatial frequency selectivity. Since the quantitative analysi…

13C NMR study of some polychloro-isobutane and -isobutene compounds

1984

The 13C chemical shifts and the carbon–proton coupling constants have been determined for some chlorinated isobutane and isobutene compounds. The one-bond coupling constants in isobutane derivatives showed a regular increase with an increasing number of γ-chlorine substituents. The three-bond coupling constant of the methyl carbon decreased from 4.2 to 2.0 Hz as the number of chlorine substituents in the γ-position increased. In the isobutene compounds, the vicinal coupling of C-1 was larger to protons in a group that is trans with respect to a chlorine substituent on C-1 than to those in the corresponding group cis to the chlorine. The vicinal coupling constants between atoms in geminal gr…

Age-dependent changes of nuclear envelope protein phosphokinase and protein phosphatase activities. Significance for altered nucleo-cytoplasmic mRNA …

1984

Nuclear envelopes are associated with a protein phosphokinase and a phosphoprotein phosphatase, whose activities are modulated by poly(A) in an opposite manner. The activities of these enzymes were determined in nuclear ghosts from liver and oviduct of quails of different age and of different hormone status. Under optimal conditions, kinase activity was found to increase in immature animals 8-fold in response to diethylstilbestrol; co-administration of progesterone had no marked effect on enzyme activity. After the initial burst, the activity of the enzyme increased only slightly during ageing. Two proteins present in nuclear ghosts of Mr 64 000 and of Mr 106 000 are phosphorylated during t…

Darstellung und polymerisation von diestern aus 2,2′-methylendiphenolen und acryl-, methacryl- bzw. Crotonsäure

1984

Several mono- and diesters of four selected 2,2′-methylenediphenols with acrylic, methacrylic, and crotonic acid were synthesized for the first time. Special emphasis was paid to the preparation of diesters with two different acyl groups which could be obtained via the corresponding monoesters. The radical polymerization of these esters with AIBN (mainly in benzene) gave insoluble (crosslinked) products from dimethacrylates and soluble (linear) polymers from mixed diesters with methacrylic and crotonic acid, while the dicrotonates are not reactive.

false

1984

The decomposition reactions of the lithiated dimer, trimer, and tetramer of methyl methacrylate (MMA) in THF at 25°C were investigated. The decomposition of the lithiated dimer proceeds via depolymerization to lithiated monomer and MMA, addition of MMA to residual lithiated dimer, resulting the trimer (“disproportionation” of the dimer), and subsequent autocondensation of the products. The lithiated trimer almost exclusively undergoes cyclo-autocondensation, whereas for the lithiated tetramer both reactions proceed simultaneously to a remarkable degree. It is shown that the relative rate of autocondensation, which is highly dependent on the degree of polymerization of the oligomer, controls…

Crystal and molecular structure of the tris(1,10-phenanthroline)potassium salt of μ-hydridobis[pentacarbonylchromium(0)]

1984

Abstract The crystal and molecular structure of [K(phen)3][Cr2(CO)10(μ-H)] has been determined by X-ray diffraction. The compound crystallizes in the space group P 1 with a 11.884(4), b 13.968(4), c 15.612(6) A, α 112.6(1), β 99.7(1) and γ 106.2(1)° and Z = 2. The structure was refined to R = 0.066 and RW = 0.067 for 3692 counter data with I ⩾ 3σ(I). The complex anion [Cr2(CO)10(μ-H)] adopts a bent Cr-H-Cr configuration with the equatorial carbonyl groups of the two independent Cr(CO)5 moieties in an eclipsed configuration. The Cr⋯Cr distance is 3.394(3) A and the two CrH bonds are 1.74(7) and 1.71(7) A. The CrHCr bond angle is 159(3)°. In the dimeric complex cation [K(phen)3]2, located …

Endogenous 3-methylhistidine excretion in healthy women and men with reference to muscle protein metabolism.

1984

Presently 3-methylhistidine excretion is widely used for monitoring the metabolic status of patients during different kinds of clinical conditions. Aim of the study was to reconsider its predicative value on the basis of a larger collective of healthy persons and to find a standardization independent from sex. Therefore endogenous 3-methylhistidine release of 40 healthy adults (24 women and 16 men) was measured and related to body weight, body surface area, arm muscle circumference, and nitrogen and creatinine excretion. A positive correlation could be observed only for 3-methylhistidine and creatinine excretion and that to the same extent both for females and males. Assuming that the excre…

Attitudes Toward Professional Foreign Players in Finnish Amateur Basketball

1984

The use of foreign professional players may influence the host country's sport culture. To determine the attitudes toward foreign professionals in various Finnish amateur basketball leagues, all clubs (n = 55) playing basketball in the three highest Finnish leagues were interviewed by mailed questionnaire. The results indicated that recruitment of foreign pros was held to effect negatively the team spirit and the play tactics, the economics of the club, the development of other sport branches in the club and the success of the national team. Positive effects were expected on the number of spectators, public relations of the club and the success of its team. For lower leagues foreign profes…

Stochastic seismic analysis of offshore towers

1984

After a brief review of the main problems and the most common analysis methods for offshore structures, a method of analysis for offshore towers submerged in water and subjected to strong earthquake motions is proposed. Nonlinear drag effects as well as random non-stationary seismic excitations are considered by means of a linearization technique based on a particular step-by-step procedure. Using a discrete lumped-mass model, the standard deviations of nodal displacements and velocities are evaluated. The probability of not exceeding a defined threshold of nodal displacements is also computed.

Possible coumarin-like mechanism of action for cephalosporins.

1984

In three patients treated with cephalosporins (one patient with latamoxef, two patients with cefazedone) vitamin K1 was injected to investigate whether this was followed by an increase in vitamin K1 2,3-epoxide plasma concentrations as compared to controls. Such a rise in K1-epoxide concentrations in the plasma can be demonstrated following treatment with coumarins. This reflects an inhibition of the vitamin K1-epoxide reductase in the liver. Coumarins are thought to induce hypoprothrombinaemia by such a mechanism. In all three patients we found a considerable increase in the vitamin K1-epoxide plasma concentrations following injection of 10 mg vitamin K1, whereas in normal subjects only tr…

Extended thermodynamics and superfluidity

1984

Exploitation des consequences de la thermodynamique generalisee en appliquant ses equations a un gaz de Bose degenere ou la condensation de Bose-Einstein a lieu. Formes particulieres de ces equations, qui gouvernent la dissipation, pour 4 He. Equation du second son

Intermediate filaments of normal and neoplastic tissues of the female genital tract with emphasis on problems of differential tumor diagnosis

1984

Cytokeratins of normal epithelia and of some neoplasms of the female genital tract were studied by immunofluorescence microscopy of frozen sections and by two-dimensional gel electrophoresis of cytoskeletal proteins from microdissected tissues. All normal epithelia were stained with the monoclonal cytokeratin antibody KG 8.13 whereas certain monoclonal antibodies stained only simple epithelia. As revealed by gel electrophoresis the normal epithelia of the ovarian surface, oviduct, endometrium and endocervix contained cytokeratin polypeptides Nos. 7, 8, 18 and 19. In contrast, stratified exocervical epithelium showed a much more complex pattern (polypeptides No. 1, 2, 4, 5, 6, 11, 13, 14, 15…

Experimental Verification of the Determination of Atmospheric Turbidity from Sunshine Recorders

1984

Abstract The feasibility of determining atmospheric turbidity from the burned traces of Campbell-Stokes sunshine recorders during cloudless sunsets and sunrises is examined experimentally. Results show that atmospheric turbidity can be determined in this way and can provide data for climatological research over the period of existing sunshine records. However, the measurements show a substantial uncertainty in the results if the properties of the used record cards are unknown. For networks of recorders, the method remains useful despite these limitations.

Replication of HSV-1 in murine peritoneal macrophages: comparison of various virus strains with different properties.

1984

The in vitro replication of eleven different strains of herpes simplex virus type 1 was studied in resident or thioglycollate-stimulated mouse macrophages. The strains of herpes simplex virus differed in the type of cytopathic effect, induction capacity for herpes simplex virus coded thymidine kinase and pathogenicity in the mouse. Herpes simplex virus replicated better in thioglycollate-stimulated macrophages than in resident macrophages. In vitro ageing of macrophages increased their replicative potency. Herpes simplex virus replicated better in macrophages from homozygous bg/bg C57/BL6J mice than in macrophages from their heterozygous littermates. Separation of macrophages on discontinuo…

Photoaffinity labeling of the coupling factor 1 from the thermophilic bacterum PS3 by 8-azido ATP

1984

AbstractTo localize the nucleotide binding sites of the F1ATPase (TF1) from the thermophilic bacterium PS3 we have used 14C-labeled 8-azido ATP (8-N3ATP) as photoaffmity label. 8-N3ATP is hydrolyzed by the F,ATPase in the absence of ultraviolet light. Irradiation by ultraviolet light of the enzyme in the presence of 8-N3ATP results in reduction of ATPase activity and in preferential nucleotide specific labeling of the α subunits (0.8–0.9 mol 8-N3ATP/TF1,α:β = 4:1). Inactivation and labeling do not depend on the presence of Mg2+. Both effects decrease upon addition of various nucleotide di- or triphosphates.

Mass spectral identification of the blocked N-terminal tryptic peptide of the ATPase inhibitor from beef heart mitochondria

1984

AbstractThe presence of a formyl blocking group at the N-terminus of the ATPase inhibitor has been identified and the partial sequence of the N-terminal peptide has been determined by fast atom bombardment and field desorption coupled to mass spectrometry. Minor discrepancies in amino acid sequence of the inhibitor between the present and published data [(1981) Proc. Natl. Acad. Sci. USA 78, 7403-7407] are reported and its relationships with other inhbitors are briefly discussed.

Molecular structure ofo-chloro-N-β-cyanoethyl-anilide

1984

Resonant Nuclear Fusion Processes and the Gamma Rays of SS 433

1984

Gamma-ray spectral lines have recently been reported coming from the celestial object SS 433, which is known to emit high-speed jets in opposite directions. The proposed identification of the lines as coming from fusion reactions on nitrogen nuclei as part of the carbon-nitrogen-oxygen cycle operating in the jets has now received observational support. Predictions of strengths and widths of additional lines which, if seen, would provide valuable new information about conditions giving rise to the jets are presented.

Comparative column chromatographic estimations of phenylalanine in plasma, whole blood, native and paper-dried capillary blood of healthy children an…

1984

The concentration of phenylalanine in plasma, whole venous and capillary blood, and paper-dried blood of 75 probands (25 healthy adults, 27 healthy children, and 23 patients with hyperphenylalaninaemia) were measured by use of a sensitive short column chromatography method. The comparison of the values in each group of probands by several statistic methods showed an excellent correlation of the phenylalanine concentration in paper-dried whole blood to those measured in venous plasma. Evaluation of the analytical method revealed a high sensitivity and accuracy by use of a sample volume of 50 microliter. We would therefore suggest that the estimation of phenylalanine for the diagnosis and the…

RELEVANCE OF MESENCHYMAL THYMUS CELLS (MC) FOR ACCEPTANCE OF ALLOGENEIC MATURE THYMUS GRAFTS AND INDUCTION OF ALLOTOLERANCE IN NUDE MICE

1984

Allogeneic thymus (aTh) from an adult immunocompetent donor cannot be transplanted successfully in thymusless nude mice even if the graft is irradiated. The graft is destroyed for unknown reasons and no immunocompetence is achieved in the host. Two approaches were established to achieve acceptance of aTh. In experiment 1, mature aTh was transplanted in nude mice, after specific tolerance to the recipient was induced in the donor during the neonatal period. This resulted in acceptance of the aTh, immunological reconstitution and tolerance to the donor's and recipient's MHC-haplotype as proved by skin-grafts and MLC. In experiment 2, neonatal thymus was grafted into allogeneic nude mice and r…

Cost recovery in education : a summary of four recent papers

1984

référence interne : 84052

High-performance and ion-exchange chromatography and chromatofocusing of the human uterine progesterone receptor: its application to the identificati…

1984

Two independent lines of evidence were used to identify the human uterine progesterone receptor. First, three differently tritiated progestogens (Org 2058, R 5020, progesterone) were used for reversible labelling of the receptor. Secondly, the highly potent affinity label 21-[3H]dehydro Org 2058 was used to label covalently the steroid-specific binding site of the receptor. The labelled cytosols were chromatographed on a Mono Q high-performance anion-exchange column in the absence or presence of a high molar excess of the respective unlabelled competitor steroids. In the case of 21-[3H]dehydro Org 2058, Org 2058 was used as the unlabelled competitor. After elution with a NaCl gradient, the …

L'enseignement supérieur en Afrique de l'ouest francophone : synthèse de cinq études de cas (Bénin, Cameroun, Côte d'Ivoire, Haute-Volta, Sénégal) : …

1984

référence interne : 84061

A facile microsynthesis of 14C-labelled picene

1984

Microscale Wittig olefination of commercially available [7-14C]-benzal dehyde of high specific radioactivity with aryl bromomethyl phosphonium salt and subsequent oxidative photocyclisation affords pure 14C-labelled picene in efficient yield.

7,8‐Dihydroimidazo[1,2‐ c ]pyrimidin‐5(6 H )‐one, ‐5(6 H )‐thione und ‐5(6 H )‐ylidencyanamide

1984

Die Cyclisierung der 4,5-substituierten 2-(2-Aminoethyl)imidazole 5 mit Dimethyl-N-cyandithioimidocarbonat (2), 1,1′-Carbonyldiimidazol (10a) oder 1,1′-Thiocarbonyldiimidazol (10b) ergibt die bisher nicht beschriebenen Titel-Verbindungen 7, 11 und 14. Die 1H- und 13C-NMR-Daten sowie des Verhalten gegenuber Nucleophilen werden beschrieben.

User charges for education : the ability ans willingness to pay in Malawi

1984

Investment in education is generally recognized to be essential for a country's long-term economic and social development. However, presentmacroeconomic conditions in many developing countries have obliged their governments to slow down increases in the allocation of public resources for education. As a result, the education sector is likely to develop only slowly, if at all; enrollment, already low in the poorer of the developing countries, would remain low, while the social demand for education would continue to be substantially unmet. In this setting, policy makers have recently focussed their attention on finding alternative sources of finance for education, one of which is the tapping …