The effect of Dextransulfate 500 on the pathogenesis of herpes simplex virus infections in weanling mice

1978

Intraperitoneal (i.p.) injection of Dextran Sulfate (D.S.) 500 during a limited period of time influences the course of herpes simplex-virus-infections. D.S.500 was found to reduce the resistance of mice for some herpes simplex-virus strains (Len, L3-2s, Haase) if given between 16 hours before and 2 hours after i.p. infection. The decrease of resistance could be correlated with an increase of the virus content of liver, spleen, brain and spinal cord. Injection of herpes simplex-virus-specific immune serum counteracted the effect of D.S.500 on the course of infections. Conversely, D.S.500 increased the resistance of mice to another group of herpes simplex-viruses (strains D-316, Thea, DD), i…

STUDIEN ZUM VORGANG DER WASSERSTOFFÜBERTRAGUNG 551Zur selektiven elektroreduktiven Spaltung von Arylsulfonsäureestern

1978

Abstract In para-Stellung der Arylsulfonsaureester eingefuhrte Substituenten uben einen starken Einflus auf die Lage der Halbstufenpotentiale aus. Sie verschieben das Potential in folgender Reihenfolge nach negativeren Werten: (p-)C2H5O2C · (p-)Cl > (p-)CH3-CH3-CONH > (p-)CH3O. Die Potentialdifferenz zwischen den Estern mit parastandigen OCH3-und Carboxyethylgruppen liegt bei ca. 800 mV (vgl. Tabelle I). Die Halbstufenpotentiale gehorchen annahernd der Hammett-Beziehung (vgl. Abbildung 1). Der Einflus der Struktur des Alkylrestes in den Arylsulfonsaureestern auf die Lage der Halbstufenpotentiale ist gering. Die Arylsulfonsaurephenylester liegen durchweg um ca. 200 mV positiver als die entsp…

Herstellung und Charakterisierung flüssig-kristalliner Polymere mit cholesterischer Phase

1978

Final report on the CERN muon storage ring including the anomalous magnetic moment and the electric dipole moment of the muon, and a direct test of r…

1978

Abstract A comprehensive description of the muon storage ring and its operation is given, and the final results of the experiment are presented and discussed. The anomalous magnetic moments of positive and negative muons are found to be aμ+ = 1165911(11) × 10−9 and aμ− = 1165937(12) × 10−9 giving an average value for muons of aμ = 1165924(8.5) × 10−9. The electric dipole moments were also measured with the results Dμ+= (8.6 ± 4.5) × 10−9e · cm and Dμ− = (0.8 ± 4.3) × 10−19e · cm. Under the assumption of the CPT theorem these yield a weighted average of Dμ = (3.7 ± 3.4) × 10−19e · cm. Finally the time transformation of special relativity is shown to be valid to (0.8 ± 0.7) × 10−3 at γ ≅ 29.3…

Les nouvelles contraintes dans les politiques de réduction des inégalités dans l'éducation

1978

International audience

Eine einfache Darstellung von 8-Azidoadenosin-5′-triphosphat; ein Agens zur Photoaffinitätsmarkierung von ATP-bindenden Proteinen

1978

Eine vereinfachte Synthese von 8-Azido-ATP (3) wird beschrieben. Die neue Methode ist kurzer und fuhrt zu wesentlich besseren Ausbeuten als die bekannte Methode. Neben 3 entstehen dabei 8-Azido-ADP und 8-Azido-AMP. Es wurden mit einem Reaktionsansatz alle drei 8-Azidonucleotide gleichzeitig erhalten. 8-Azido-ATP (3) wurde durch Elementaranalyse, Dunnschichtchromatographie, Infrarotspektroskopie und UV-Absorptionsspektroskopie charakterisiert. Die Photolyse bei verschiedenen pH-Werten wurde untersucht. Durch F1ATPase wird 3 umgesetzt. A Facile Synthesis of 8-Azidoadenosine 5′-Triphosphate; a Photoaffinity Label for ATP-Binding Proteins A simple procedure for the synthesis of 8-azido-ATP (3) …

The active venous pulse in the wing circulation of bats (Chiroptera). A contribution to comparative angiology.

1978

Measurements of cytochrome f and P-700 in intact leaves of Sinapis alba grown under high-light and low-light conditions

1978

The oxidation and reduction of cytochrome f and P-700 is measured spectrophotometrically in leaves of low-light and high-light plants. After illumination with red light, an induction phenomenon for cytochrome f oxidation is observed which indicates a regulation of photosystem I activity through energy distribution between the pigment systems by the energy state of the membrane. After far-red excitation the reduction of cytochrome f in the dark is much slower in low-light leaves. This shows that cyclic electron transport is not improved in low-light plants under these conditions. P-700 is oxidized on excitation with far-red light. However, with high intensities of far-red light, P-700 is par…

Quelques réflexions sur les relations entre l'éducation et l'emploi au niveau de l'enseignement supérieur en France

1978

Document préparé à l'intention des participants au séminaire sur l'enseignement supérieur et l'emploi organisé par l'UNESCO à Paris du 4 au 7 décembre 1978

CARDIAC PUNCTURE OF FETUS WITH HURLER'S DISEASE AVOIDING ABORTION OF UNAFFECTED CO-TWIN

1978

SYMPATHETIC NERVOUS SYSTEM AND BLOOD-PRESSURE CONTROL IN ESSENTIAL HYPERTENSION

1978

Abstract In normotensive subjects an inverse correlation was observed between an index of sympathetic nervous activity (the plasma-noradrenaline concentration during physical exercise) and reactivity to exogenous noradrenaline. This relationship was invariably disturbed in age-matched patients with essential hypertension. Multiple-regression analysis revealed a highly significant correlation between the combination of both factors and the height of mean arterial blood-pressure ( r =0·91). The findings suggest that sympathetic nervous activity and pressor response to noradrenaline together form an important determinant of the arterial blood-pressure level. An inverse relationship could be de…

The effect of dopamine on the overflow of endogenous noradrenaline from the perfused rabbit heart evoked by sympathetic nerve stimulation.

1978

1. The effects of dopamine and two dopamine receptor antagonists (pimozide, flupenthixol) on the release of endogenous noradrenaline evoked by electrical stimulation of the postganglionic sympathetic nerves and their influence on cardiac performance were measured in isolated perfused rabbit hearts. 2. Dopamine 0.2μM decreased noradrenaline overflow and ventricular tension development in response to nerve stimulation. 3. Dopamine 2μM increased spontaneous noradrenaline output and tension development. The noradrenaline overflow in response to nerve stimulation was greatly enhanced. This action was only partly reversed by wash out of exogenous dopamine, indicating de novo synthesis and facilit…

Die thermische Polymerisation von Methylmethacrylat, 1. Polymerisation in Substanz

1978

Special purification of the monomer and careful preparation of the reaction setup allowed a thorough study of the spontaneous thermal polymerization of methyl methacrylate over a wide range of temperatures (0–140°C). The rates of polymerization are notably lower than the few data previously reported in literature, and the degrees of polymerization slightly higher. The thermal initiation reaction is superimposed by radical production due to the natural ionising radiation (cosmic radiation etc.). This additional initiation becomes significant at temperatures below 60°C. New and more reliable monomer chain transfer constants are given.

Molekül- und kristallstruktur von hexamethylcyclo-tristannaselenan [(CH3)2SnSe]3

1978

Hexamethylcyclotristannaselenane [(CH3)2SnSe]3 forms tetragonal crystals, space groups P41212, with a  986.5(2), c  1769.7(4) pm, Z  4. The complete X-ray structural analysis (two independent determinations) shows the six-membered ring to have a twist-boat conformation similar to [(CH3)2SnS]3. The SnSe2C2 tetrahedra are only slightly distorted, the mean bond distances being SnSe 253.1 (251.7⋯254.0(4)) pm, Sn C 2.13 (2.09⋯2.17(3)) pm. Conformational details are discussed.

Late results of bladder stimulation in 11 patients: followup to 4 years.

1978

Abstract Direct stimulation of the detrusor muscle offers the best possibility to evacuate the bladder in highly selected patients. During the last 4 years 11 patients have undergone implantation of a bladder pacemaker. Followup revealed that 1 patient could void only during stimulation, while 7 patients had reflex evacuation and 3 had no function at all. An exceptional case report is presented.

Diagnostic and therapeutic problems of myxomas (myxofibromas) of the jaws

1978

During the period from 1969 to 1977 11 cases of myxoma or myxofibroma in the jaw region have been treated at the Maxillofacial Surgery Clinic of the University of Mainz. Various kinds of diagnostic problems are discussed. We observed, inter alia, rapid tumour growth and a imitative dynamics in the radiographs, giving rise to a suspicion of malignancy in some cases. The locally infiltrative type of growth of myxomas must be taken into account during therapy, since insufficiently radical management is liable to be followed by a recurrence.

Transverse momenta of partons and dimuons in QCD

1978

Abstract Intrinsic (primordial) transverse momenta of quarks and gluons are calculated as well as those arising from recoil (bremsstrahlung) effects, using only the well-known parton distributions as input. The intrinsic kT's lie typically in the range of 150–250 MeV. Recent approaches using heuristic integro-differential equations for kT distributions of partons are shown to disagree with the results obtained by rigorous QCD calculations. The transverse momenta of dimuon pairs produced in pp → μ+μ− + X at the ISR can be solely explained by dynamical recoil effects, i.e., q q →(μ + μ − ) g and gq →(μ + μ − ) q , and no significant intrinsic transverse parton momenta are required. These dimu…

Results of the measurements carried out in order to verify the validity of the poisson-exponential distribution in radioactive decay events

1978

Abstract Berkson, examining a series of 250,000 disintegration time intervals, found a significant departure of the distribution from the Poisson-exponential law. Therefore he proposed to repeat the experiment using a large number of intervals and to check the interval recordings by using more than one recording instrument simultaneously. Accepting these suggestions we developed two systems of data collecting provided with different controls. In several experiments we collected data for more than one million decay intervals. The results elaborated using the Pearson ξ 2 test reflect a Poisson process of the radioactive decay events.

Modifications induced in the renin-angiotensin-aldo-sterone system of rats by alpha-blocking drugs.

1978

Summary The data reported in the present paper refer to quantitative variations of plasma renin activity and plasma aldosterone levels after administration of alpha-blocking agents, i.e. phentolamine, phenoxybenzamine and gihydroergotoxin derivatives, either to rats kept on a standard diet with water ad libitum or to rats receiving distilled water load, the latter treatment causing an increase of both plasma renin activity and plasma aldosterone levels if compared to control values. No strict correlation between (a) drug-induced modifications of plasma renin activity and plasma aldosterone levels and (b) blood pressure drop caused by the same drugs was shown to occur under either experiment…

Compressive recovery behaviour of a polycarbonate

1978

Abstract Polycarbonate samples were subjected to large compression strains (beyond yielding) and were unloaded after some degree of stress relaxation. The subsequent deformation recovery was measured for several values of strain, loading rate and duration of stress relaxation. All the data could be reported as a single curve by normalizing the recovered strain with the stress at the end of the relaxation period.

false

1978

Theoretical relations for the dependence of the z-average radius of gyration Rz as a function of the mass average molar mass Mw are derived for expanded coils, persistence coils with persistence of direction, persistence coils with persistence of direction and curvature, and for needles, all exhibiting a Schulz-distribution of their molar masses. These relations are applied to experimental data from light scattering of polystyrene in toluene and DNA-Na in aqueous NaCl-solution of 200 mol NaCl per m3 at room temperature. In the case of DNA it becomes evident that the double helix shows no important persistence of curvature and that the experimental data can be described adequately by a persi…

L'allocation des ressources à l'éducation dans le monde

1978

référence interne : 78009

Analyse économique des nouveaux média éducatifs

1978

International audience

Attitudes des individus et des familles à l'égard de la formation et de l'emploi

1978

International audience

Anterior fusion for cervical spondylosis

1978

Anterior fusion was performed on 138 patients as treatment for degenerative changes of the cervical vertebral column. The results were checked after up to 11 years in 122 patients and were found to be good in 55%, fair in 3895% and poor in 6.5%. There were complications of phonetic paralysis in one case, Horner syndrome in two cases, 2 wound infections, and complaints about the iliac crest in 3 patients. Kyphosis at the fused segment occurred 26.1% of cases, the average angle being 15.3 degrees, but it did not influence the clinical results. Mortality was 2%. Inadequate visualization of the nerve roots at operation was probably the reason for the segmental deficits and suggestions were made…

Studien zum Vorgang der Wasserstoffübertragung, 54. Mechanismus und Grenzen der Clemmensen-Reduktion des Acetophenons und verwandter Verbindungen

1978

Bei der Reduktion von Acetophenon nach Clemmensen entstehen auser Ethylbenzol (1; Vier-Elektronen-Ubergang) in von den Reaktionsbedingungen abhangigen Mengen das Hydrodimerisierungsprodukt 2,3-Diphenyl-2,3-butandiol (2; Ein-Elektronen-Ubergang) und dessen Umlagerungsverbindungen 3 und 4, aber weder 1-Phenylethanol noch Styrol (Zwei-Elektronen-Ubergang). Temperatur, Saurekonzentration, Saureart, Reduktionsmittel (amalgamiertes Zink, Zinkamalgam, Cadmium, Zink-Cadmium-Legierung, Cadmiumamalgam, Magnesiumamalgam, Blei, Zink, Blei-Legierung) bestimmen die Anteile der gebildeten Reduktionsprodukte 1 — 4. 1-Phenylethanol und Styrol konnen unter Clemmensen-Bedingungen partiell in Ethylbenzol (1) u…

?-Glucuronidase activity in trained red and white skeletal muscle of mice

1978

We studied the effects of prolonged running exercise (5 days a week, 1.5 h per day at a speed of 17.6 m/min) on the activity of some acid hydrolases (beta-glucuronidase, beta-N-acetylglucosaminidase, acid phosphatase and cathepsin D) and three enzymes of energy metabolism (cytochrome c oxidase, lactate dehydrogenase and creatine kinase) in the distal and in the proximal, the predominantly white and red parts, respectively, of the vastus lateralis-muscle from mice. The acid hydrolase activity levels were 1.24--1.69 higher in untrained red muscle compared to untrained white muscle. The light training applied increased the activity of beta-glucuronidase in both red and white muscle. No other s…

Differential inhibition of biphenyl hydroxylation in perfused rat liver

1978

A differential inhibition of biphenyl hydroxylation by alpha-naphthoflavone and metyrapone was observed in isolated perfused rat liver. alpha-Naphthoflavone inhibited 2- and 4-hydroxylation in livers from beta-naphthoflavone-pretreated animals but had no effect on both reactions in livers from phenobarbital-pretreated animals. Metyrapone inhibited 2- and 4-hydroxylation in phenobarbital-stimulated livers, but only insignificant inhibition of 2-hydroxylation and a slight enhancement of 4-hydroxylation by metyrapone was observed in beta-naphthoflavone-stimulated livers. Conjugation of 2-hydroxybiphenyl and 4-hydroxybiphenyl by isolated perfused livers was also studied. 4-Hydroxybiphenyl prefe…

Species-dependent stereospecific serum protein binding of the oral anticoagulant drug phenprocoumon

1978

13 mammalian species are classified into 3 clearcut groups with respect to the stereospecific serum protein-binding of phenprocoumon: 2 groups showing opposed stereospecific binding characteristics and a 3rd group exhibiting no stereospecific binding. Structural differences in the albumin molecule account for these stereospecific differences in serum protein-binding.

Partial purification and some properties of a nucleoside phosphotransferase of chick embryos.

1978

A nucleoside phosphotransferase purified about 40fold from chick embryos utilizes efficiently as phosphate donors deoxyribonucleoside and pyrimidine ribonucleoside monophosphates, whereas the pyrimidine deoxyribonucleoside appear to be the preferred acceptors of phosphate. The enzyme is very unstable to heat, dilution and dialysis. A marked enhancement in the stability is caused by nucleotides and it seems associated with the formation of an aggregated state of the protein.

Studien zum Vorgang der Wasserstoffübertragung, 53. Beitrag zur Kenntnis der elektroreduktiven Spaltung von Hydroxylaminderivaten

1978

Die Elektroreduktion von 26 Hydroxylaminderivaten wird polarographisch und an 6 Beispielen praparativ untersucht. Es wurde gefunden: 1) Dreifach mit Alkyl- oder Arylgruppen substituierte Hydroxylaminderivate werden bis zu einem Potential von -2.5 V (gegen Ag/AgCl/KClges.) nicht elektroreduziert. — 2) Der Einbau von Acylgruppen erleichtert in Abhangigkeit von Art, Zahl und Verknupfungsstelle die Elektroreduktion. Acylreste mit aromatischen Gruppen verschieben das Halbstufenpotential starker nach positiven Werten als aliphatisch substituierte Acylreste (entsprechend: Phthaloyl > Benzoyl > Formyl > Acetyl > Ethoxycarbonyl). Acylgruppen am Sauerstoff des Hydroxylamins fordern die Elektroredukti…

Studien zum Vorgang der Wasserstoffübertragung, 52. Zur Kenntnis der elektroreduktiven Spaltung der N - N-Bindung

1978

Am Beispiel von 35 Hydrazinderivaten wird die elektroreduktive Spaltung polarographisch und praparativ untersucht. Es wurde gefunden: 1) Beim mono-, tri- und tetrabenzoylierten Hydrazin 9, 11 bzw. 12 verschiebt sich das Potential proportional der Anzahl der Benzoylgruppen nach positiveren Werten. Beim symmetrischen 1,2-Dibenzoylhydrazin (10) wird das Halbstufenpotential E1/2 — bedingt durch H-Verbruckung und mesomere Stabilisierung — stark nach negativen Werten verschoben. — 2) Bei den cyclischen Hydrazinderivaten 14–16 werden die E1/2-Werte sowohl in Abhangigkeit von der Ringspaltung als auch durch cis-Fixierung der Benzoylgruppen noch zusatzlich nach positiveren Werten verlagert. — 3) Ube…

Détermination des biais liés à la saisie des données et aux différences individuelles dans la lecture des paysages

1978

International audience

false

1978

Transformacion raiz cuadrada versus logaritmica de una distribucion Gamma

1978

Utilizando la divergencia de Kullback-Leibler, hemos comparado las transformaciones raiz cuadrada y logaritmica de una distribucion Gamma, sugeridas para conseguir una aproximacion a la distribucion normal.

Treatment with essential amino acids in patients on chronic hemodialysis: a double blind cross-over study.

1978

Patients on chronic hemodialysis may suffer from a latent protein deficiency, and therapy with essential amino acids has been recommended. In a double blind cross-over study, 13 hemodialysis patients received orally 15.7 g of essential amino acids daily over a 3-month period. Patients were on a liberal diet, containing 1 g of protein per kilogram of body weight per day. Hemodialysis was adequate. Therapy resulted in an increase in urea, uric acid, C3 c complement factor and a fall in C4. Lysine levels increased and phenylalanine fell. Malnutrition could not account for the observed metabolic changes, which are more likely due to uremic metabolic disturbances. A liberal diet of 1 g of protei…